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View Structure Prediction Details

Protein: PROF2_DICDI
Organism: Dictyostelium discoideum
Length: 124 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PROF2_DICDI.

Description E-value Query
Range
Subject
Range
PROF1_RICCO - Profilin-1 OS=Ricinus communis GN=PRO1 PE=2 SV=1
190.0 [0..1] [123..1]
PROF_LITCN - Profilin OS=Litchi chinensis PE=1 SV=1
189.0 [0..1] [123..1]
PROF_ANACO - Profilin OS=Ananas comosus PE=1 SV=1
187.0 [0..1] [123..1]
gi|77416979 - gi|77416979|gb|ABA81885.1| profilin-like [Solanum tuberosum]
187.0 [0..1] [123..1]
PROF_CHEAL - Profilin OS=Chenopodium album PE=1 SV=1
186.0 [0..1] [123..1]
PROF2_SOLLC - Profilin-2 OS=Solanum lycopersicum PE=1 SV=1
186.0 [0..1] [122..1]
PROFX_ORYSI - Profilin LP04 OS=Oryza sativa subsp. indica GN=OsI_020954 PE=1 SV=2
PROFX_ORYSJ - Profilin LP04 OS=Oryza sativa subsp. japonica GN=Os06g0152100 PE=2 SV=1
185.0 [0..1] [124..1]
PROF1_PHAVU - Profilin-1 OS=Phaseolus vulgaris PE=1 SV=1
185.0 [0..1] [123..1]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTWQAYVDNN LLGAGFASAA LLGAADGSVW AHSAGFNVAE GKAITALFQK DGAAFATGIH  60
   61 VAGKKYMAIK SDTRSAYGKL GAGGVVCVKT LTCIIVAVYD DKLQPGAAAN IAEKLADYLI 120
  121 DNNC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.522879
Match: 1g5uA
Description: Profilin (actin-binding protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 7.981958446142 bayes_pls_golite062009
cytoskeletal protein binding 6.51470611165788 bayes_pls_golite062009
actin monomer binding 3.80837480536839 bayes_pls_golite062009
binding 3.26636517628678 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 3.24248939295046 bayes_pls_golite062009
protein binding 2.14534188091242 bayes_pls_golite062009
phosphoinositide binding 1.69872978885701 bayes_pls_golite062009
phospholipid binding 1.52027694872856 bayes_pls_golite062009
transporter activity 1.434681455285 bayes_pls_golite062009
transmembrane transporter activity 1.23300160340736 bayes_pls_golite062009
active transmembrane transporter activity 0.490905558612378 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle