YRC Public Data Repository - Protein Structure Prediction

Protein:	PHOQ_ECOLI
Organism:	Escherichia coli
Length:	486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHOQ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|194437076, gi... - gi\|83587301\|ref\|ZP_00925929.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 101-1...	270.0	[0..1]	[486..1]
gi\|170020478, gi... - gi\|170020478\|ref\|YP_001725432.1\| sensor protein PhoQ [Escherichia coli ATCC 8739], gi\|169755406\|gb\|A... gi\|75511665, gi\|... - gi\|75511665\|ref\|ZP_00734312.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638... gi\|75195310, gi\|... - gi\|75195310\|ref\|ZP_00705380.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|124529874, gi... - gi\|124529874\|ref\|ZP_01700718.1\| integral membrane sensor signal transduction histidine kinase [Esche...	270.0	[0..1]	[486..1]
gi\|25298440, gi\|... - pir\|\|A99829 sensor protein PhoQ [imported] - Escherichia coli (strain O157:H7, substrain RIMD 050995... gi\|217318512, gi... - gi\|217328085\|ref\|ZP_03444167.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. TW14588]... gi\|15830855, gi\|... - gi\|15830855\|ref\|NP_309628.1\| PhoQ [Escherichia coli O157:H7], gi\|13361065\|dbj\|BAB35024.1\| sensor pro... gi\|208805732, gi... - gi\|208805732\|ref\|ZP_03248069.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4206],... gi\|208732466, gi... - gi\|208815818\|ref\|ZP_03256997.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4045],... gi\|208738181, gi... - gi\|208822696\|ref\|ZP_03263015.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4042],... gi\|209397549, gi... - gi\|209397549\|ref\|YP_002270046.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4115]... gi\|168776058, gi... - gi\|187768516\|gb\|EDU32360.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|189000067, gi... - gi\|189000067\|gb\|EDU69053.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|168787604, gi... - gi\|189372549\|gb\|EDU90965.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|168800459, gi... - gi\|189377297\|gb\|EDU95713.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|168749732, gi... - gi\|188016022\|gb\|EDU54144.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|189356409, gi... - gi\|189356409\|gb\|EDU74828.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|189367121, gi... - gi\|189367121\|gb\|EDU85537.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4501], gi\|... gi\|189360163, gi... - gi\|189360163\|gb\|EDU78582.1\| sensor histidine kinase PhoQ [Escherichia coli O157:H7 str. EC4486], gi\|... gi\|15830855, gi\|... - gi\|15830855\|ref\|NP_309628.1\| sensor protein PhoQ [Escherichia coli O157:H7 str. Sakai], gi\|13361065\|... gi\|254591989, gi... - gi\|254792589\|ref\|YP_003077426.1\| sensory histidine kinase in two-component regulatory system with Ph...	269.0	[0..1]	[486..1]
gi\|81241408, gi\|... - gi\|82777260\|ref\|YP_403609.1\| sensor protein PhoQ [Shigella dysenteriae Sd197], gi\|81241408\|gb\|ABB621...	269.0	[0..1]	[486..1]
PHOQ_SHIFL - Virulence sensor protein PhoQ OS=Shigella flexneri GN=phoQ PE=3 SV=1 gi\|110614705, gi... - gi\|110805157\|ref\|YP_688677.1\| sensor protein PhoQ [Shigella flexneri 5 str. 8401], gi\|110614705\|gb\|A... gi\|24051443, gi\|... - gi\|24112548\|ref\|NP_707058.1\| sensor protein PhoQ [Shigella flexneri 2a str. 301], gi\|24051443\|gb\|AAN... gi\|30062676, gi\|... - gi\|30062676\|ref\|NP_836847.1\| sensor protein PhoQ [Shigella flexneri 2a str. 2457T], gi\|30040924\|gb\|A...	268.0	[0..1]	[486..1]
gi\|75255667, gi\|... - gi\|75255667\|ref\|ZP_00727439.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|194412416, gi... - gi\|75209209\|ref\|ZP_00709456.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|195182816 - gi\|195182816\|dbj\|BAG66392.1\| two-component sensor kinase [Escherichia coli O111:H-]	268.0	[0..1]	[486..1]
PHOQ_ECO57 - Sensor protein PhoQ OS=Escherichia coli O157:H7 GN=phoQ PE=3 SV=3	267.0	[0..1]	[486..1]
gi\|75239627, gi\|... - gi\|75239627\|ref\|ZP_00723594.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|91071859, gi\|... - gi\|91210285\|ref\|YP_540271.1\| sensor protein PhoQ [Escherichia coli UTI89], gi\|91071859\|gb\|ABE06740.1... gi\|110641306, gi... - gi\|110641306\|ref\|YP_669036.1\| sensor protein PhoQ [Escherichia coli 536], gi\|110342898\|gb\|ABG69135.1... PHOQ_ECOL6 - Sensor protein PhoQ OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=phoQ PE=3 SV=1 gi\|237706885, gi... - gi\|237706885\|ref\|ZP_04537366.1\| sensor protein phoQ [Escherichia sp. 3_2_53FAA], gi\|226898095\|gb\|EEH... gi\|117623314, gi... - gi\|117623314\|ref\|YP_852227.1\| sensor protein PhoQ [Escherichia coli APEC O1], gi\|115512438\|gb\|ABJ005... gi\|227836718, gi... - gi\|227886514\|ref\|ZP_04004319.1\| sensory histidine kinase in two-compoent regulatory system with PhoP... PHOQ_ECOL6 - Sensor protein PhoQ OS=Escherichia coli O6 GN=phoQ PE=3 SV=1 gi\|215486383, gi... - gi\|215486383\|ref\|YP_002328814.1\| sensor protein PhoQ [Escherichia coli O127:H6 str. E2348/69], gi\|21... gi\|218558011, gi... - gi\|218558011\|ref\|YP_002390924.1\| sensor protein PhoQ [Escherichia coli S88], gi\|218364780\|emb\|CAR024...	267.0	[0..1]	[486..1]
gi\|213417019 - gi\|213417019\|ref\|ZP_03350163.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typ... gi\|213428094 - gi\|213428094\|ref\|ZP_03360844.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typ... gi\|16760105 - gi\|16760105\|ref\|NP_455722.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typhi ... gi\|213648226 - gi\|213648226\|ref\|ZP_03378279.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typ... gi\|214002206 - gi\|214002206\|ref\|ZP_03412941.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typ... PHOQ_SALTI - Virulence sensor histidine kinase phoQ OS=Salmonella typhi GN=phoQ PE=3 SV=1 gi\|213052792 - gi\|213052792\|ref\|ZP_03345670.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typ... PHOQ_SALTI - Virulence sensor histidine kinase PhoQ OS=Salmonella typhi GN=phoQ PE=3 SV=1 gi\|29137753, gi\|... - gi\|29142124\|ref\|NP_805466.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Typhi ...	264.0	[0..1]	[486..1]
PHOQ_SALTY - Virulence sensor histidine kinase PhoQ OS=Salmonella typhimurium GN=phoQ PE=1 SV=2 PHOQ_SALCH - Virulence sensor histidine kinase PhoQ OS=Salmonella choleraesuis GN=phoQ PE=3 SV=1 gi\|194711021, gi... - gi\|194735519\|ref\|YP_002114237.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Sc... gi\|194469479, gi... - gi\|194469479\|ref\|ZP_03075463.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Ken... gi\|194407393, gi... - gi\|194449089\|ref\|YP_002045232.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar He... gi\|194444857, gi... - gi\|194444857\|ref\|YP_002040486.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Ne... PHOQ_SALCH - Virulence sensor histidine kinase phoQ OS=Salmonella choleraesuis GN=phoQ PE=3 SV=1 gi\|199603068, gi... - gi\|200390623\|ref\|ZP_03217234.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Vir... PHOQ_SALPA - Virulence sensor histidine kinase PhoQ OS=Salmonella paratyphi A GN=phoQ PE=3 SV=1 gi\|198245737, gi... - gi\|198245737\|ref\|YP_002215905.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Du... gi\|197362707, gi... - gi\|197362707\|ref\|YP_002142344.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Pa... gi\|197243194, gi... - gi\|197264939\|ref\|ZP_03165013.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Sai... gi\|197288118, gi... - gi\|197288118\|gb\|EDY27505.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Schwarz... gi\|168233112, gi... - gi\|205332663\|gb\|EDZ19427.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Kentuck... gi\|238910950 - gi\|238910950\|ref\|ZP_04654787.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Ten... gi\|205329789, gi... - gi\|205329789\|gb\|EDZ16553.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar 4,[5],1... PHOQ_SALT1 - Virulence sensor histidine kinase PhoQ OS=Salmonella typhimurium (strain 14028s / SGSC 2262) GN=phoQ... gi\|161363899, gi... - gi\|161614535\|ref\|YP_001588500.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Pa... gi\|205341209, gi... - gi\|205341209\|gb\|EDZ27973.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Weltevr... PHOQ_SALTU - Virulence sensor histidine kinase PhoQ OS=Salmonella typhimurium (strain ATCC 68169 / UK-1) GN=phoQ ... PHOQ_SALCH - Virulence sensor histidine kinase PhoQ OS=Salmonella choleraesuis (strain SC-B67) GN=phoQ PE=3 SV=1 gi\|168467192, gi... - gi\|195630462\|gb\|EDX49088.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Newport... PHOQ_SALTS - Virulence sensor histidine kinase PhoQ OS=Salmonella typhimurium (strain SL1344) GN=phoQ PE=1 SV=1 gi\|205347305, gi... - gi\|205347305\|gb\|EDZ33936.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Hadar s... gi\|205336754, gi... - gi\|205336754\|gb\|EDZ23518.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Heidelb... PHOQ_SALTY - Virulence sensor histidine kinase PhoQ OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 70072... PHOQ_SALPA - Virulence sensor histidine kinase PhoQ OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=phoQ... gi\|224584262, gi... - gi\|224584262\|ref\|YP_002638060.1\| sensor protein PhoQ, regulator of virulence determinants [Salmonell... gi\|206709066, gi... - gi\|207857263\|ref\|YP_002243914.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar En... gi\|205272817, gi... - gi\|205353036\|ref\|YP_002226837.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Ga... gi\|204930875, gi... - gi\|204930875\|ref\|ZP_03221748.1\| sensor protein PhoQ [Salmonella enterica subsp. enterica serovar Jav... PHOQ_SALTY - Virulence sensor histidine kinase phoQ OS=Salmonella typhimurium GN=phoQ PE=1 SV=2	264.0	[0..1]	[486..1]

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Predicted Domain #1

Region A:
Residues: [1-169]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKLLRLFFP LSLRVRFLLA TAAVVLVLSL AYGMVALIGY SVSFDKTTFR LLRGESNLFY  60
   61 TLAKWENNKL HVELPENIDK QSPTMTLIYD ENGQLLWAQR DVPWLMKMIQ PDWLKSNGFH 120
  121 EIEADVNDTS LLLSGDHSIQ QQLQEVREDD DDAEMTHSVA VNVYPATSR

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	114.958607
Match:	PF08918.1
Description:	No description for PF08918.1 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [170-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKLTIVVVD TIPVELKSSY MVWSWFIYVL SANLLLVIPL LWVAAWWSLR PIEALAKEVR  60
   61 ELEEHNRELL NPATTRELTS LVRNLNRLLK SERERYDKYR TTLTDLTHSL KTPLAVLQST 120
  121 LRSLRSEKMS VSDAEPVMLE QISRISQQIG YYLHRASM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.06
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [328-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGGTLLSREL HPVAPLLDNL TSALNKVYQR KGVNISLDIS PEISFVGEQN DFVEVMGNVL  60
   61 DNACKYCLEF VEISARQTDE HLYIVVEDDG PGIPLSKREV IFDRGQRVDT LRPGQGVGLA 120
  121 VAREITEQYE GKIVAGESML GGARMEVIFG RQHSAPKDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.30103
Match:	1id0A
Description:	Histidine kinase PhoQ domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.57884608485164	bayes_pls_golite062009
transferase activity	0.66560190725226	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.65281383212182	bayes_pls_golite062009
kinase activity	0.64987928624127	bayes_pls_golite062009
signal transducer activity	0.47895126364598	bayes_pls_golite062009
molecular transducer activity	0.47895126364598	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.41458536707017	bayes_pls_golite062009
protein kinase activity	0.41262128363539	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.270144402236579	bayes_pls_golite062009
protein histidine kinase activity	0.27006997723077	bayes_pls_golite062009
two-component sensor activity	0.22080838371957	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: