YRC Public Data Repository - Protein Structure Prediction

Protein:	PHF1_CLOPA
Organism:	Clostridium pasteurianum
Length:	574 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHF1_CLOPA.

Description	E-value	Query Range	Subject Range
gi\|125972863, gi... - gi\|67916533\|ref\|ZP_00510240.1\| Ferredoxin:4Fe-4S ferredoxin, iron-sulfur binding domain:Iron hydroge...	606.0	[0..1]	[574..3]
gi\|4927278 - gi\|4927278\|gb\|AAD33071.1\| hydrogenase-1 [Clostridium thermocellum]	602.0	[0..1]	[574..1]
gi\|82402638, gi\|... - gi\|82499410\|ref\|ZP_00884856.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chai...	601.0	[0..1]	[574..3]
gi\|20807375, gi\|... - gi\|20807375\|ref\|NP_622546.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain ... gi\|20807375 - gi\|20807375\|ref\|NP_622546.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain ...	584.0	[0..2]	[574..4]
gi\|167037864, gi... - gi\|76795773\|ref\|ZP_00778144.1\| Ferredoxin:4Fe-4S ferredoxin, iron-sulfur binding:Iron hydrogenase, s... gi\|241884287, gi... - gi\|241903376\|ref\|ZP_04788101.1\| hydrogenase, Fe-only [Thermoanaerobacter brockii subsp. finnii Ako-1...	583.0	[0..2]	[574..4]
gi\|158140165, gi... - gi\|158319966\|ref\|YP_001512473.1\| hydrogenase, Fe-only [Alkaliphilus oremlandii OhILAs], gi\|158140165...	576.0	[0..1]	[574..1]
gi\|14250935 - gi\|14250935\|emb\|CAC39231.1\| HymC protein [Eubacterium acidaminophilum]	571.0	[0..1]	[574..1]
gi\|88924523, gi\|... - gi\|88945916\|ref\|ZP_01149055.1\| NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chai...	567.0	[0..2]	[572..4]
gi\|160881923, gi... - gi\|160881923\|ref\|YP_001560891.1\| hydrogenase, Fe-only [Clostridium phytofermentans ISDg], gi\|1604305...	563.0	[0..2]	[574..4]
gi\|85858940, gi\|... - gi\|85858940\|ref\|YP_461142.1\| iron only hydrogenase large subunit [Syntrophus aciditrophicus SB], gi\|...	560.0	[0..2]	[574..8]

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Predicted Domain #1

Region A:
Residues: [1-574]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTIIINGVQ FNTDEDTTIL KFARDNNIDI SALCFLNNCN NDINKCEICT VEVEGTGLVT  60
   61 ACDTLIEDGM IINTNSDAVN EKIKSRISQL LDIHEFKCGP CNRRENCEFL KLVIKYKARA 120
  121 SKPFLPKDKT EYVDERSKSL TVDRTKCLLC GRCVNACGKN TETYAMKFLN KNGKTIIGAE 180
  181 DEKCFDDTNC LLCGQCIIAC PVAALSEKSH MDRVKNALNA PEKHVIVAMA PSVRASIGEL 240
  241 FNMGFGVDVT GKIYTALRQL GFDKIFDINF GADMTIMEEA TELVQRIENN GPFPMFTSCC 300
  301 PGWVRQAENY YPELLNNLSS AKSPQQIFGT ASKTYYPSIS GLDPKNVFTV TVMPCTSKKF 360
  361 EADRPQMEKD GLRDIDAVIT TRELAKMIKD AKIPFAKLED SEADPAMGEY SGAGAIFGAT 420
  421 GGVMEAALRS AKDFAENAEL EDIEYKQVRG LNGIKEAEVE INNNKYNVAV INGASNLFKF 480
  481 MKSGMINEKQ YHFIEVMACH GGCVNGGGQP HVNPKDLEKV DIKKVRASVL YNQDEHLSKR 540
  541 KSHENTALVK MYQNYFGKPG EGRAHEILHF KYKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	150.0
Match:	1c4aA
Description:	Fe-only hydrogenase, catalytic domain; Fe-only hydrogenase, N-terminal domain; Fe-only hydrogenase, second domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on hydrogen as donor	6.64236715107187	bayes_pls_golite062009
ferredoxin hydrogenase activity	3.6648131134538	bayes_pls_golite062009
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	3.6648131134538	bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors	3.24851281788501	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	1.92608685564304	bayes_pls_golite062009
binding	1.47874003627413	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	1.31458462821219	bayes_pls_golite062009
NADH dehydrogenase activity	1.10428419414285	bayes_pls_golite062009
lamin binding	0.863386378061341	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	0.778342926116907	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.312816353615077	bayes_pls_golite062009
protein binding	0.221871950373022	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.10097776114013	bayes_pls_golite062009
electron carrier activity	0.0554226204149908	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: