YRC Public Data Repository - Protein Structure Prediction

Protein:	PFLF_ECOLI
Organism:	Escherichia coli
Length:	810 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFLF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|73854845, gi\|... - gi\|74311368\|ref\|YP_309787.1\| putative formate acetyltransferase [Shigella sonnei Ss046], gi\|73854845...	1086.0	[0..1]	[810..1]
gi\|218694297, gi... - gi\|218694297\|ref\|YP_002401964.1\| putative glycyl radical cofactor protein [Escherichia coli 55989], ... gi\|209911331, gi... - gi\|209918072\|ref\|YP_002292156.1\| putative formate acetyltransferase [Escherichia coli SE11], gi\|2099... gi\|218360177, gi... - gi\|218553409\|ref\|YP_002386322.1\| putative glycyl radical cofactor protein [Escherichia coli IAI1], g... gi\|75257579, gi\|... - gi\|75257579\|ref\|ZP_00729076.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E22], gi\|193064492\|... gi\|75230671, gi\|... - gi\|75230671\|ref\|ZP_00717142.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B7A], gi\|191166137\|... gi\|75210581, gi\|... - gi\|75210581\|ref\|ZP_00710729.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B171], gi\|194428223...	1086.0	[0..1]	[810..1]
gi\|188494675, gi... - gi\|75512828\|ref\|ZP_00735320.1\| COG1882: Pyruvate-formate lyase [Escherichia coli 53638], gi\|18849467...	1086.0	[0..1]	[810..1]
gi\|82776090, gi\|... - gi\|82776090\|ref\|YP_402437.1\| putative formate acetyltransferase [Shigella dysenteriae Sd197], gi\|812...	1086.0	[0..1]	[810..1]
gi\|237707214, gi... - gi\|237707214\|ref\|ZP_04537695.1\| conserved hypothetical protein [Escherichia sp. 3_2_53FAA], gi\|22689... gi\|218557727, gi... - gi\|218557727\|ref\|YP_002390640.1\| putative glycyl radical cofactor protein [Escherichia coli S88], gi... gi\|227884213, gi... - gi\|227884213\|ref\|ZP_04002018.1\| formate acetyltransferase 3 [Escherichia coli 83972], gi\|227838965\|g... gi\|117623002, gi... - gi\|117623002\|ref\|YP_851915.1\| putative formate acetyltransferase 3 [Escherichia coli APEC O1], gi\|11... gi\|91071431, gi\|... - gi\|91209857\|ref\|YP_539843.1\| putative formate acetyltransferase 3 [Escherichia coli UTI89], gi\|91071...	1085.0	[0..1]	[810..1]
gi\|75178385, gi\|... - gi\|75178385\|ref\|ZP_00698439.1\| COG1882: Pyruvate-formate lyase [Shigella boydii BS512], gi\|187733614...	1085.0	[0..1]	[810..1]
gi\|26107197, gi\|... - gi\|26246798\|ref\|NP_752838.1\| putative formate acetyltransferase 3 [Escherichia coli CFT073], gi\|2610...	1085.0	[0..1]	[810..1]
gi\|81244679, gi\|... - gi\|82543268\|ref\|YP_407215.1\| putative formate acetyltransferase [Shigella boydii Sb227], gi\|81244679...	1084.0	[0..1]	[810..1]
gi\|193069369, gi... - gi\|75236120\|ref\|ZP_00720244.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E110019], gi\|193069...	1084.0	[0..1]	[810..1]
gi\|157077806, gi... - gi\|75189864\|ref\|ZP_00703131.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E24377A], gi\|157155...	1083.0	[0..1]	[810..1]

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Predicted Domain #1

Region A:
Residues: [1-810]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTLKLDTLS DRIKAHKNAL VHIVKPPVCT ERAQHYTEMY QQHLDKPIPV RRALALAHHL  60
   61 ANRTIWIKHD ELIIGNQASE VRAAPIFPEY TVSWIEKEID DLADRPGAGF AVSEENKRVL 120
  121 HEVCPWWRGQ TVQDRCYGMF TDEQKGLLAT GIIKAEGNMT SGDAHLAVNF PLLLEKGLDG 180
  181 LREEVAERRS RINLTVLEDL HGEQFLKAID IVLVAVSEHI ERFAALAREM AATETRESRR 240
  241 DELLAMAENC DLIAHQPPQT FWQALQLCYF IQLILQIESN GHSVSFGRMD QYLYPYYRRD 300
  301 VELNQTLDRE HAIEMLHSCW LKLLEVNKIR SGSHSKASAG SPLYQNVTIG GQNLVDGQPM 360
  361 DAVNPLSYAI LESCGRLRST QPNLSVRYHA GMSNDFLDAC VQVIRCGFGM PAFNNDEIVI 420
  421 PEFIKLGIEP QDAYDYAAIG CIETAVGGKW GYRCTGMSFI NFARVMLAAL EGGHDATSGK 480
  481 VFLPQEKALS AGNFNNFDEV MDAWDTQIRY YTRKSIEIEY VVDTMLEENV HDILCSALVD 540
  541 DCIERAKSIK QGGAKYDWVS GLQVGIANLG NSLAAVKKLV FEQGAIGQQQ LAAALADDFD 600
  601 GLTHEQLRQR LINGAPKYGN DDDTVDTLLA RAYQTYIDEL KQYHNPRYGR GPVGGNYYAG 660
  661 TSSISANVPF GAQTMATPDG RKAHTPLAEG ASPASGTDHL GPTAVIGSVG KLPTAAILGG 720
  721 VLLNQKLNPA TLENESDKQK LMILLRTFFE VHKGWHIQYN IVSRETLLDA KKHPDQYRDL 780
  781 VVRVAGYSAF FTALSPDAQD DIIARTEHML

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1r8wA
Description:	Native structure of the B12-independent glycerol dehydratase from clostridium butyricum
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.73003832721087	bayes_pls_golite062009
catalytic activity	2.3210268917648	bayes_pls_golite062009
formate C-acetyltransferase activity	1.54402969935508	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	1.01884781068403	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups	0.886317513633828	bayes_pls_golite062009
ribonucleoside-diphosphate reductase activity	0.586669339206518	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: