YRC Public Data Repository - Protein Structure Prediction

Protein:	PFLD_ECOLI
Organism:	Escherichia coli
Length:	765 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFLD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|49258688, gi\|... - gi\|49258689\|pdb\|1R9E\|B Chain B, Structure Of The B12-Independent Glycerol Dehydratase With 1,2-Propa...	973.0	[0..2]	[763..10]
gi\|77918998, gi\|... - gi\|77918998\|ref\|YP_356813.1\| glycerol dehydratase [Pelobacter carbinolicus DSM 2380], gi\|77545081\|gb...	956.0	[0..2]	[765..17]
gi\|75209363, gi\|... - gi\|75209363\|ref\|ZP_00709599.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B171], gi\|194429421...	946.0	[0..1]	[765..1]
gi\|218556512, gi... - gi\|218556512\|ref\|YP_002389426.1\| putative formate acetyltransferase 2 [Escherichia coli IAI1], gi\|21... gi\|192929381, gi... - gi\|75258065\|ref\|ZP_00729526.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E22], gi\|193063916\|... gi\|75227819, gi\|... - gi\|75227819\|ref\|ZP_00714537.1\| COG1882: Pyruvate-formate lyase [Escherichia coli B7A], gi\|191168938\|...	945.0	[0..1]	[765..1]
gi\|75176659, gi\|... - gi\|75176659\|ref\|ZP_00696787.1\| COG1882: Pyruvate-formate lyase [Shigella boydii BS512], gi\|187732803... gi\|81247713, gi\|... - gi\|82546302\|ref\|YP_410249.1\| putative formate acetyltransferase 2 [Shigella boydii Sb227], gi\|812477...	945.0	[0..1]	[765..1]
gi\|110807807, gi... - gi\|110807807\|ref\|YP_691327.1\| putative formate acetyltransferase 2 [Shigella flexneri 5 str. 8401], ... gi\|24115241, gi\|... - gi\|24115241\|ref\|NP_709751.1\| putative formate acetyltransferase 2 [Shigella flexneri 2a str. 301], g... gi\|30043022, gi\|... - gi\|30064762\|ref\|NP_838933.1\| putative formate acetyltransferase 2 [Shigella flexneri 2a str. 2457T],...	944.0	[0..1]	[765..1]
gi\|192958725, gi... - gi\|75238396\|ref\|ZP_00722395.1\| COG1882: Pyruvate-formate lyase [Escherichia coli E110019], gi\|193068...	944.0	[0..1]	[765..1]
gi\|75513863, gi\|... - gi\|75513863\|ref\|ZP_00736216.1\| COG1882: Pyruvate-formate lyase [Escherichia coli 53638], gi\|18849429...	943.0	[0..1]	[765..1]
gi\|242379487, gi... - gi\|251787214\|ref\|YP_003001518.1\| hypothetical protein B21_03785 [Escherichia coli BL21], gi\|24237948... gi\|157163428, gi... - gi\|75197824\|ref\|ZP_00707894.1\| COG1882: Pyruvate-formate lyase [Escherichia coli HS], gi\|157163428\|r... gi\|254163901, gi... - gi\|254163901\|ref\|YP_003047009.1\| predicted formate acetyltransferase 2 (pyruvate formate lyase II) [... gi\|194438365, gi... - gi\|83586205\|ref\|ZP_00924841.1\| COG1882: Pyruvate-formate lyase [Escherichia coli 101-1], gi\|19443836... gi\|124501317, gi... - gi\|124527615\|ref\|ZP_01699080.1\| pyruvate formate-lyase [Escherichia coli B], gi\|124501317\|gb\|EAY4878... gi\|253979959, gi... - gi\|254290652\|ref\|YP_003056400.1\| predicted formate acetyltransferase 2 (pyruvate formate lyase II) [... gi\|170022037, gi... - gi\|170022037\|ref\|YP_001726991.1\| putative formate acetyltransferase 2 [Escherichia coli ATCC 8739], ...	942.0	[0..1]	[765..1]
gi\|81243021, gi\|... - gi\|82778873\|ref\|YP_405222.1\| putative formate acetyltransferase 2 [Shigella dysenteriae Sd197], gi\|8...	942.0	[0..1]	[765..1]

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Predicted Domain #1

Region A:
Residues: [1-765]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNRISRLKT ALFANTREIS LERALLYTAS HRQTEGEPVI LRRAKATAYI LEHVEISIRD  60
   61 EELIAGNRTV KPRAGIMSPE MDPYWLLKEL DQFPTRPQDR FAISEEDKRI YREELFPYWE 120
  121 KRSMKDFING QMTDEVKAAT NTQIFSINQT DKGQGHIIID YPRLLNHGLG ELVAQMQQHC 180
  181 QQQPENHFYQ AALLLLEASQ KHILRYAELA ETMAANCTDA QRREELLTIA EISRHNAQHK 240
  241 PQTFWQACQL FWYMNIILQY ESNASSLSLG RFDQYMLPFY QTSLTQGEDA AFLKELLESL 300
  301 WVKCNDIVLL RSTSSARYFA GFPTGYTALL GGLTENGRSA VNVLSFLCLD AYQSVQLPQP 360
  361 NLGVRTNALI DTPFLMKTAE TIRFGTGIPQ IFNDEVVVPA FLNRGVSLED ARDYSVVGCV 420
  421 ELSIPGRTYG LHDIAMFNLL KVMEICLHEN EGNAALTYEG LLEQIRAKIS HYITLMVEGS 480
  481 NICDIGHRDW APVPLLSSFI SDCLEKGRDI TDGGARYNFS GVQGIGIANL SDSLHALKGM 540
  541 VFEQQRLSFD ELLSVLKANF ATPEGEKVRA RLINRFEKYG NDIDEVDNIS AELLRHYCKE 600
  601 VEKYQNPRGG YFTPGSYTVS AHVPLGSVVG ATPDGRFAGE QLADGGLSPM LGQDAQGPTA 660
  661 VLKSVSKLDN TLLSNGTLLN VKFTPATLEG EAGLRKLADF LRAFTQLKLQ HIQFNVVNAD 720
  721 TLREAQQRPQ DYAGLVVRVA GYSAFFVELS KEIQDDIIRR TAHQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1r8wA
Description:	Native structure of the B12-independent glycerol dehydratase from clostridium butyricum
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.95058695475279	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	1.72563679072631	bayes_pls_golite062009
formate C-acetyltransferase activity	1.48261557970472	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups	1.43559439297918	bayes_pls_golite062009
oxidoreductase activity	1.42705638794743	bayes_pls_golite062009
ribonucleoside-diphosphate reductase activity	1.37298861502572	bayes_pls_golite062009
C-acyltransferase activity	0.0923196663496405	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: