YRC Public Data Repository - Protein Structure Prediction

Protein:	PANB_ECOLI
Organism:	Escherichia coli
Length:	264 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PANB_ECOLI.

Description	E-value	Query Range	Subject Range
PANB_ALTMD - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Alteromonas mediterranea (strain DSM 17117 / CIP... PANB_ALTMD - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Alteromonas macleodii (strain DSM 17117 / Deep e...	351.0	[0..1]	[264..1]
gi\|147676555, gi... - gi\|98661989\|dbj\|GAA01057.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476765...	350.0	[0..3]	[263..5]
gi\|85859368, gi\|... - gi\|85859368\|ref\|YP_461570.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Syntrophus aciditroph...	348.0	[0..2]	[263..14]
gi\|88926139, gi\|... - gi\|88944133\|ref\|ZP_01147466.1\| Ketopantoate hydroxymethyltransferase [Desulfotomaculum reducens MI-1...	348.0	[0..2]	[264..3]
gi\|27262460 - gi\|27262460\|gb\|AAN87511.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Heliobacillus mobilis]	348.0	[0..2]	[263..3]
gi\|68515580, gi\|... - gi\|68546769\|ref\|ZP_00586314.1\| Ketopantoate hydroxymethyltransferase [Shewanella amazonensis SB2B], ...	348.0	[0..1]	[264..16]
PANB_PSEA6 - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Pseudoalteromonas atlantica (strain T6c / ATCC B...	347.0	[0..1]	[263..1]
gi\|227073351, gi... - gi\|227519212\|ref\|ZP_03949261.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Enterococcus faeca... gi\|227553672, gi... - gi\|227553672\|ref\|ZP_03983721.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Enterococcus faeca... gi\|48825284 - ref\|ZP_00286549.1\| COG0413: Ketopantoate hydroxymethyltransferase [Enterococcus faecium] gi\|229545554, gi... - gi\|229545554\|ref\|ZP_04434279.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Enterococcus faeca... PANB_ENTFA - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Enterococcus faecalis (strain ATCC 700802 / V583... gi\|69246071, gi\|... - gi\|69246071\|ref\|ZP_00603798.1\| Ketopantoate hydroxymethyltransferase [Enterococcus faecium DO], gi\|6... PANB_ENTFA - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Enterococcus faecalis GN=panB PE=3 SV=1	347.0	[0..1]	[263..1]
gi\|59713811, gi\|... - gi\|59713811\|ref\|YP_206586.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Vibrio fischeri ES114...	346.0	[0..1]	[263..26]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPTTISLLQ KYKQEKKRFA TITAYDYSFA KLFADEGLNV MLVGDSLGMT VQGHDSTLPV  60
   61 TVADIAYHTA AVRRGAPNCL LLADLPFMAY ATPEQAFENA ATVMRAGANM VKIEGGEWLV 120
  121 ETVQMLTERA VPVCGHLGLT PQSVNIFGGY KVQGRGDEAG DQLLSDALAL EAAGAQLLVL 180
  181 ECVPVELAKR ITEALAIPVI GIGAGNVTDG QILVMHDAFG ITGGHIPKFA KNFLAETGDI 240
  241 RAAVRQYMAE VESGVYPGEE HSFH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.69897
Match:	1m3uA
Description:	Ketopantoate hydroxymethyltransferase PanB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-methyl-2-oxobutanoate hydroxymethyltransferase activity	4.08693637310631	bayes_pls_golite062009
catalytic activity	2.59838799615646	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	2.05689968523792	bayes_pls_golite062009
transferase activity	1.07154136609184	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.646649320021871	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.366715189574293	bayes_pls_golite062009
oxo-acid-lyase activity	0.0960362356555544	bayes_pls_golite062009
carbon-carbon lyase activity	0.0846611486307003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: