YRC Public Data Repository - Protein Structure Prediction

Protein:	MURE_SYNY3
Organism:	Synechocystis sp. PCC 6803
Length:	505 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MURE_SYNY3.

Description	E-value	Query Range	Subject Range
MURE_CALS4 - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Caldanaerobacter subterrane... MURE_THETN - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Thermoanaerobacter tengcong...	416.0	[0..2]	[502..1]
MURE1_CLOAB - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 1 OS=Clostridium acetobutylicu... MURE1_CLOAB, MUE... - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 1 OS=Clostridium acetobutylicu...	415.0	[0..2]	[502..1]
gi\|20808076, gi\|... - gi\|20808076\|ref\|NP_623247.1\| UDP-N-acetylmuramyl tripeptide synthase [Thermoanaerobacter tengcongens... gi\|20808076 - gi\|20808076\|ref\|NP_623247.1\| UDP-N-acetylmuramyl tripeptide synthase [Thermoanaerobacter tengcongens...	415.0	[0..2]	[502..11]
gi\|166856057, gi... - gi\|76796234\|ref\|ZP_00778600.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter ethanol... gi\|167040637, gi... - gi\|167040637\|ref\|YP_001663622.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter sp. X... gi\|242257445, gi... - gi\|242257445\|ref\|ZP_04802310.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Thermoanaerobacter sp. X5...	407.0	[0..2]	[502..1]
gi\|71672845, gi\|... - gi\|71673597\|ref\|ZP_00671345.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Trichodesmium erythraeum I...	406.0	[0..2]	[504..11]
gi\|49329337, gi\|... - gi\|49477781\|ref\|YP_036697.1\| UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [Bac...	402.0	[0..2]	[500..1]
MURE_CLOTE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Clostridium tetani GN=murE ... MURE_CLOTE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase OS=Clostridium tetani (strain ...	399.0	[0..2]	[502..1]
gi\|67922594, gi\|... - gi\|67922594\|ref\|ZP_00516100.1\| UDP-N-acetylmuramyl-tripeptide synthetase [Crocosphaera watsonii WH 8...	399.0	[0..30]	[503..25]
gi\|47568717, gi\|... - gi\|47568717\|ref\|ZP_00239413.1\| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase [Ba...	399.0	[0..24]	[503..19]
gi\|42781669, gi\|... - gi\|42781669\|ref\|NP_978916.1\| UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate ligase [Baci...	398.0	[0..2]	[503..1]

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Predicted Domain #1

Region A:
Residues: [1-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKLGQLLAS VPEVVAAAPW LAQESDRCPA LGKIVTGLST NSHACPPGTL FIGMPGTRVD  60
   61 GGEFWSGALE AGAIAAVVSE KALQKFPPQN GECVIAVPDL VPVCAGLAAA FYQHPAQTLQ 120
  121 LVGVTGTNGK TTTSHLIEYF LNQQQRSSAL LGTLYTRWPG YQKTATHTTP FATDLQKQLA 180
  181 EALQAGNQYA VMEVSSHALA QGRVLQCGFA CAVFTNLTQD HLDFHGTMEN YFAAKALLFK 240
  241 ESYLQGRAVI NQDDPYGQRL IDRLPLDQVY TYSVNDSTAD FYTKDLDYQP TGVKGTFVTP 300
  301 QGEFPFLSPL VGQFNLANVL AAIASGLHLG LDPAAMVKDL LDFPGVPGRM EQVQIRPDQD 360
  361 ISVMVDYAHT PDSLENALKA ARPFIPGRLI CIFGCGGDRD RTKRPLMGNI AAQLADLAVV 420
  421 TSDNPRTEDP EQILADVVQG ISLDIEPWII GDRATAIHKA IREAKPGDGV LIAGKGHEDY 480
  481 QILGTEKIHF DDREQAREAL ILRYS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.09691
Match:	1e8cA
Description:	UDP-N-acetylmuramyl tripeptide synthetase MurE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acid-amino acid ligase activity	4.86493054281191	bayes_pls_golite062009
catalytic activity	3.03081854683329	bayes_pls_golite062009
UDP-N-acetylmuramate-L-alanine ligase activity	2.62956763198067	bayes_pls_golite062009
UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity	2.38541436302257	bayes_pls_golite062009
ligase activity	2.2556848409907	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.19206014001612	bayes_pls_golite062009
UDP-N-acetylmuramoylalanine-D-glutamate ligase activity	1.471039191151	bayes_pls_golite062009
UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity	1.15437935952018	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: