YRC Public Data Repository - Protein Structure Prediction

Protein:	MTLD_ECOLI
Organism:	Escherichia coli
Length:	382 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTLD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110617278, gi... - gi\|110807730\|ref\|YP_691250.1\| mannitol-1-phosphate 5-dehydrogenase [Shigella flexneri 5 str. 8401], ...	498.0	[0..1]	[382..59]
gi\|26250239, gi\|... - gi\|26250239\|ref\|NP_756279.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli CFT073], gi\|2611...	495.0	[0..1]	[382..61]
gi\|115515000, gi... - gi\|117625876\|ref\|YP_859199.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli APEC O1], gi\|11... gi\|237703367, gi... - gi\|237703367\|ref\|ZP_04533848.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia sp. 3_2_53FAA], gi... gi\|91213111, gi\|... - gi\|91213111\|ref\|YP_543097.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli UTI89], gi\|91074...	493.0	[0..1]	[382..61]
gi\|110345433, gi... - gi\|110643841\|ref\|YP_671571.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli 536], gi\|110345...	489.0	[0..1]	[382..6]
gi\|190909407, gi... - gi\|75242617\|ref\|ZP_00726361.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	488.0	[0..1]	[382..1]
gi\|21483850 - gi\|21483850\|gb\|AAM52982.1\| mannitol-1-phosphate dehydrogenase [Dunaliella bardawil]	487.0	[0..1]	[382..1]
gi\|188493923, gi... - gi\|75514333\|ref\|ZP_00736641.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|254163527, gi... - gi\|254163527\|ref\|YP_003046635.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli B str. REL60... gi\|83588548, gi\|... - gi\|83588548\|ref\|ZP_00927172.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... MTLD_ECOL6 - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O6 GN=mtlD PE=3 SV=2 MTLD_ECO81 - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O81 (strain ED1a) GN=mtlD PE=3 SV=1 MTLD_ECOSM - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=mtlD PE=3 SV=1 MTLD_ECOL6 - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) ... gi\|242379121, gi... - gi\|251786848\|ref\|YP_003001152.1\| hypothetical protein B21_03406 [Escherichia coli BL21], gi\|24237912... gi\|254290277, gi... - gi\|254290277\|ref\|YP_003056025.1\| mannitol-1-phosphate 5-dehydrogenase [Escherichia coli BL21(DE3)], ...	487.0	[0..1]	[382..1]
MTLD_ECOHS - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O9:H4 (strain HS) GN=mtlD PE=3 SV=1	486.0	[0..1]	[382..1]
gi\|75228663, gi\|... - gi\|75228663\|ref\|ZP_00715284.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c...	486.0	[0..1]	[382..1]
gi\|30065126, gi\|... - gi\|30065126\|ref\|NP_839297.1\| mannitol-1-phosphate 5-dehydrogenase [Shigella flexneri 2a str. 2457T],... MTLD_ECO8A - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O8 (strain IAI1) GN=mtlD PE=3 SV=1 gi\|56480382, gi\|... - gi\|56480382\|ref\|NP_709374.2\| mannitol-1-phosphate 5-dehydrogenase [Shigella flexneri 2a str. 301], g... MTLD_ECO55 - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli (strain 55989 / EAEC) GN=mtlD PE=3 SV=1 MTLD_SHIFL - Mannitol-1-phosphate 5-dehydrogenase OS=Shigella flexneri GN=mtlD PE=1 SV=2 MTLD_ECO24 - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mtlD PE... MTLD_ECOSE - Mannitol-1-phosphate 5-dehydrogenase OS=Escherichia coli (strain SE11) GN=mtlD PE=3 SV=1	485.0	[0..1]	[382..1]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALHFGAGN IGRGFIGKLL ADAGIQLTFA DVNQVVLDAL NARHSYQVHV VGETEQVDTV  60
   61 SGVNAVSSIG DDVVDLIAQV DLVTTAVGPV VLERIAPAIA KGQVKRKEQG NESPLNIIAC 120
  121 ENMVRGTTQL KGHVMNALPE DAKAWVEEHV GFVDSAVDRI VPPSASATND PLEVTVETFS 180
  181 EWIVDKTQFK GALPNIPGME LTDNLMAFVE RKLFTLNTGH AITAYLGKLA GHQTIRDAIL 240
  241 DEKIRAVVKG AMEESGAVLI KRYGFDADKH AAYIQKILGR FENPYLKDDV ERVGRQPLRK 300
  301 LSAGDRLIKP LLGTLEYGLP HKNLIEGIAA AMHFRSEDDP QAQELAALIA DKGPQAALAQ 360
  361 ISGLDANSEV VSEAVTAYKA MQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	100.0
Match:	1lj8A
Description:	Mannitol 2-dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.16785883389468	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.3919444853018	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.27605103494323	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	1.14653069527472	bayes_pls_golite062009
oxidoreductase activity	1.13814306448308	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	0.936350322344301	bayes_pls_golite062009
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	0.268574202882	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: