YRC Public Data Repository - Protein Structure Prediction

Protein:	MQO_ECOLI
Organism:	Escherichia coli
Length:	548 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MQO_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|253974123, gi... - gi\|254162222\|ref\|YP_003045330.1\| malate:quinone oxidoreductase [Escherichia coli B str. REL606], gi\|... gi\|254288983, gi... - gi\|254288983\|ref\|YP_003054731.1\| malate:quinone oxidoreductase [Escherichia coli BL21(DE3)], gi\|2539... MQO_ECOLC - Probable malate:quinone oxidoreductase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN... gi\|188489281, gi... - gi\|75514426\|ref\|ZP_00736704.1\| COG0579: Predicted dehydrogenase [Escherichia coli 53638], gi\|1884940... gi\|194424880, gi... - gi\|83588194\|ref\|ZP_00926819.1\| COG0579: Predicted dehydrogenase [Escherichia coli 101-1], gi\|1944361... gi\|242377846, gi... - gi\|251785573\|ref\|YP_002999877.1\| hypothetical protein B21_02096 [Escherichia coli BL21], gi\|24237784...	409.0	[0..1]	[548..1]
MQO_SHIBS - Probable malate:quinone oxidoreductase OS=Shigella boydii serotype 4 (strain Sb227) GN=mqo PE=3 SV=1 MQO_SHIB3 - Probable malate:quinone oxidoreductase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) G...	409.0	[0..1]	[548..1]
gi\|75238006, gi\|... - gi\|75238006\|ref\|ZP_00722011.1\| COG0579: Predicted dehydrogenase [Escherichia coli E110019], gi\|19306... gi\|191165349, gi... - gi\|75231452\|ref\|ZP_00717821.1\| COG0579: Predicted dehydrogenase [Escherichia coli B7A], gi\|191165349... MQO_ECO24 - Probable malate:quinone oxidoreductase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=mqo P... MQO_ECO8A - Probable malate:quinone oxidoreductase OS=Escherichia coli O8 (strain IAI1) GN=mqo PE=3 SV=1	408.0	[0..1]	[548..1]
MQO_SHISS - Probable malate:quinone oxidoreductase OS=Shigella sonnei (strain Ss046) GN=mqo PE=3 SV=1 gi\|193062327, gi... - gi\|75259682\|ref\|ZP_00730984.1\| COG0579: Predicted dehydrogenase [Escherichia coli E22], gi\|193062327... gi\|194427217, gi... - gi\|75211626\|ref\|ZP_00711705.1\| COG0579: Predicted dehydrogenase [Escherichia coli B171], gi\|19442721...	408.0	[0..1]	[548..1]
MQO_ECOHS - Probable malate:quinone oxidoreductase OS=Escherichia coli O9:H4 (strain HS) GN=mqo PE=3 SV=1	408.0	[0..1]	[548..1]
gi\|75243026, gi\|... - gi\|75243026\|ref\|ZP_00726732.1\| COG0579: Predicted dehydrogenase [Escherichia coli F11], gi\|191170100... MQO_ECOL5 - Probable malate:quinone oxidoreductase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=mqo PE=...	407.0	[0..1]	[548..1]
MQO_ECOL6 - Probable malate:quinone oxidoreductase OS=Escherichia coli O6 GN=mqo PE=3 SV=1 gi\|227887268, gi... - gi\|227887268\|ref\|ZP_04005073.1\| malate:quinone oxidoreductase [Escherichia coli 83972], gi\|227835618... MQO_ECOL6 - Probable malate:quinone oxidoreductase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC...	407.0	[0..1]	[548..1]
MQO_ECO57 - Malate:quinone oxidoreductase OS=Escherichia coli O157:H7 GN=mqo PE=3 SV=1 gi\|209765686, gi... - pir\|\|C91016 probable malate quinone oxidoreductase ECs3099 [imported] - Escherichia coli (strain O15... gi\|254794109, gi... - gi\|254794109\|ref\|YP_003078946.1\| malate dehydrogenase, FAD/NAD(P)-binding domain protein [Escherichi... gi\|237704685, gi... - gi\|237704685\|ref\|ZP_04535166.1\| malate:quinone oxidoreductase [Escherichia sp. 3_2_53FAA], gi\|226901... gi\|189362852, gi... - gi\|189362852\|gb\|EDU81271.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4486], gi\|16876783... gi\|189365352, gi... - gi\|189365352\|gb\|EDU83768.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4501], gi\|16876470... gi\|189357677, gi... - gi\|189357677\|gb\|EDU76096.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4401], gi\|16875496... gi\|188016115, gi... - gi\|188016115\|gb\|EDU54237.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4113], gi\|16874961... MQO_ECOK1 - Probable malate:quinone oxidoreductase OS=Escherichia coli O1:K1 / APEC GN=mqo PE=3 SV=1 MQO_ECOUT - Probable malate:quinone oxidoreductase OS=Escherichia coli (strain UTI89 / UPEC) GN=mqo PE=3 SV=1 gi\|15832353, gi\|... - gi\|15832353\|ref\|NP_311126.1\| malate:quinone oxidoreductase [Escherichia coli O157:H7 str. Sakai], gi... MQO_ECO45 - Probable malate:quinone oxidoreductase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mqo PE=3 S... gi\|217326821, gi... - gi\|217326821\|ref\|ZP_03442904.1\| malate dehydrogenase [Escherichia coli O157:H7 str. TW14588], gi\|217... MQO_ECO5E - Probable malate:quinone oxidoreductase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mqo PE=... gi\|208738600, gi... - gi\|208818477\|ref\|ZP_03258797.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4042], gi\|2087... gi\|189375590, gi... - gi\|189375590\|gb\|EDU94006.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC508], gi\|168802426... gi\|189372790, gi... - gi\|189372790\|gb\|EDU91206.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC869], gi\|168787120... gi\|168780063, gi... - gi\|189002133\|gb\|EDU71119.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4076], gi\|16878006... gi\|187771300, gi... - gi\|187771300\|gb\|EDU35144.1\| malate dehydrogenase (acceptor) [Escherichia coli O157:H7 str. EC4196], ... gi\|208735113, gi... - gi\|208813836\|ref\|ZP_03255165.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4045], gi\|2087... gi\|208727078, gi... - gi\|208807277\|ref\|ZP_03249614.1\| malate dehydrogenase [Escherichia coli O157:H7 str. EC4206], gi\|2087... gi\|195935591 - gi\|195935591\|ref\|ZP_03080973.1\| malate:quinone oxidoreductase [Escherichia coli O157:H7 str. EC4024] gi\|194434226, gi... - gi\|194434226\|ref\|ZP_03066493.1\| malate dehydrogenase [Shigella dysenteriae 1012], gi\|194417555\|gb\|ED...	407.0	[0..1]	[548..1]
gi\|15802763, gi\|... - gi\|15802763\|ref\|NP_288790.1\| malate:quinone oxidoreductase [Escherichia coli O157:H7 EDL933], gi\|125... gi\|25346679 - gi\|25346679\|pir\|\|E85860 hypothetical protein yojH [imported] - Escherichia coli (strain O157:H7, su...	406.0	[0..1]	[548..1]
gi\|70729795, gi\|... - gi\|70729795\|ref\|YP_259534.1\| malate:quinone oxidoreductase [Pseudomonas fluorescens Pf-5], gi\|683440...	406.0	[0..22]	[548..19]

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Predicted Domain #1

Region A:
Residues: [1-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKVTAMLFS MAVGLNAVSM AAKAKASEEQ ETDVLLIGGG IMSATLGTYL RELEPEWSMT  60
   61 MVERLEGVAQ ESSNGWNNAG TGHSALMELN YTPQNADGSI SIEKAVAINE AFQISRQFWA 120
  121 HQVERGVLRT PRSFINTVPH MSFVWGEDNV NFLRARYAAL QQSSLFRGMR YSEDHAQIKE 180
  181 WAPLVMEGRD PQQKVAATRT EIGTDVNYGE ITRQLIASLQ KKSNFSLQLS SEVRALKRND 240
  241 DNTWTVTVAD LKNGTAQNIR AKFVFIGAGG AALKLLQESG IPEAKDYAGF PVGGQFLVSE 300
  301 NPDVVNHHLA KVYGKASVGA PPMSVPHIDT RVLDGKRVVL FGPFATFSTK FLKNGSLWDL 360
  361 MSSTTTSNVM PMMHVGLDNF DLVKYLVSQV MLSEEDRFEA LKEYYPQAKK EDWRLWQAGQ 420
  421 RVQIIKRDAE KGGVLRLGTE VVSDQQGTIA ALLGASPGAS TAAPIMLNLL EKVFGDRVSS 480
  481 PQWQATLKAI VPSYGRKLNG DVAATERELQ YTSEVLGLNY DKPQAADSTP KPQLKPQPVQ 540
  541 KEVADIAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.30103
Match:	1pj5A
Description:	Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with acetate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	2.24619008578137	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.65000128703365	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.63042178480709	bayes_pls_golite062009
catalytic activity	1.40171956669527	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.09945070982191	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.5230628272236	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: