YRC Public Data Repository - Protein Structure Prediction

Protein:	METF_AQUAE
Organism:	Aquifex aeolicus
Length:	296 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METF_AQUAE.

Description	E-value	Query Range	Subject Range
gi\|42554286, gi\|... - gi\|46136113\|ref\|XP_389748.1\| hypothetical protein FG09572.1 [Gibberella zeae PH-1], gi\|42554286\|gb\|E...	383.0	[0..1]	[294..1]
MTHR1_ARATH - Methylenetetrahydrofolate reductase 1 OS=Arabidopsis thaliana GN=MTHFR1 PE=1 SV=1	381.0	[0..1]	[296..1]
gi\|115384530, gi... - gi\|115384530\|ref\|XP_001208812.1\| methylenetetrahydrofolate reductase 2 [Aspergillus terreus NIH2624]...	379.0	[0..1]	[296..1]
gi\|88180522, gi\|... - gi\|88180522\|gb\|EAQ87990.1\| conserved hypothetical protein [Chaetomium globosum CBS 148.51], gi\|11619...	378.0	[0..1]	[293..1]
gi\|119178804, gi... - gi\|90299825\|gb\|EAS29456.1\| hypothetical protein CIMG_08202 [Coccidioides immitis RS], gi\|119178804\|r...	377.0	[0..1]	[290..1]
gi\|67539426, gi\|... - gi\|67539426\|ref\|XP_663487.1\| hypothetical protein AN5883.2 [Aspergillus nidulans FGSC A4], ref\|XP_41... gi\|113911583 - gi\|113911583\|gb\|ABI48273.1\| methylenetetrahydrofolate reductase [Emericella nidulans]	376.0	[0..1]	[289..1]

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Predicted Domain #1

Region A:
Residues: [1-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIGDILRKG VFSISFEFFP PKTEEGERQL FETIRKLEKL NPTFVSVTYG AGGSTRDRTR  60
   61 NIVQKIHEET NLTVMAHLTC IAHTREELID ILQDYKNIGI ENILALRGDV PRDKPDWRPP 120
  121 KGACKYAKEL VELIRKEFGD WFSIGVASYP EGHPESPNLE WEVKYFKEKV EAGADFSITQ 180
  181 MFFVNDYYYR FVEMCKNAGI DISIIPGIMP ITNFKQIRKF ASLCGATIPQ SLIEKLEKVE 240
  241 DKPEEVKKIG IEFAINQCLD LIEHGVPGLH FYTLNKSDAT LKIYEAIKDK IPARST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0
Match:	1v93A
Description:	5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methylenetetrahydrofolate reductase (NADPH) activity	4.06186780929512	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	2.68101592248617	bayes_pls_golite062009
catalytic activity	2.52571223195289	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors	2.5107658029812	bayes_pls_golite062009
oxidoreductase activity	2.12352231809478	bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity	0.973700948497381	bayes_pls_golite062009
proline dehydrogenase activity	0.78752008628955	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: