YRC Public Data Repository - Protein Structure Prediction

Protein:	LPXB_ECOLI
Organism:	Escherichia coli
Length:	382 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LPXB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|1694783 - gi\|1694783\|emb\|CAA60866.1\| lpxB [Haemophilus influenzae]	258.0	[0..1]	[382..1]
gi\|145272457, gi... - gi\|145638128\|ref\|ZP_01793738.1\| lipid-A-disaccharide synthase [Haemophilus influenzae PittII], gi\|14... gi\|46133260 - gi\|46133260\|ref\|ZP_00156903.2\| COG0763: Lipid A disaccharide synthetase [Haemophilus influenzae R286...	257.0	[0..1]	[382..1]
gi\|120325295, gi... - gi\|77952648\|ref\|ZP_00817062.1\| Glycosyl transferase, family 19 [Marinobacter aquaeolei VT8], gi\|7786...	256.0	[0..9]	[382..16]
LPXB_HAEIN - Lipid-A-disaccharide synthase OS=Haemophilus influenzae GN=lpxB PE=3 SV=2 LPXB_HAEIN - Lipid-A-disaccharide synthase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) ...	255.0	[0..1]	[382..1]
LPXB_HAEI8 - Lipid-A-disaccharide synthase OS=Haemophilus influenzae (strain 86-028NP) GN=lpxB PE=3 SV=1	255.0	[0..1]	[382..1]
gi\|46129048 - gi\|46129048\|ref\|ZP_00155774.2\| COG0763: Lipid A disaccharide synthetase [Haemophilus influenzae R284...	254.0	[0..1]	[382..1]
LPXB_SHEFN - Lipid-A-disaccharide synthase OS=Shewanella frigidimarina (strain NCIMB 400) GN=lpxB PE=3 SV=1	254.0	[0..1]	[382..1]
gi\|238787222, gi... - gi\|77972723\|ref\|ZP_00828282.1\| COG0763: Lipid A disaccharide synthetase [Yersinia frederiksenii ATCC...	252.0	[0..2]	[381..13]
LPXB_HISS2 - Lipid-A-disaccharide synthase OS=Histophilus somni (strain 2336) GN=lpxB PE=3 SV=1	252.0	[0..1]	[381..1]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEQRPLTIA LVAGETSGDI LGAGLIRALK EHVPNARFVG VAGPRMQAEG CEAWYEMEEL  60
   61 AVMGIVEVLG RLRRLLHIRA DLTKRFGELK PDVFVGIDAP DFNITLEGNL KKQGIKTIHY 120
  121 VSPSVWAWRQ KRVFKIGRAT DLVLAFLPFE KAFYDKYNVP CRFIGHTMAD AMPLDPDKNA 180
  181 ARDVLGIPHD AHCLALLPGS RGAEVEMLSA DFLKTAQLLR QTYPDLEIVV PLVNAKRREQ 240
  241 FERIKAEVAP DLSVHLLDGM GREAMVASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF 300
  301 WLAKRLVKTD YVSLPNLLAG RELVKELLQE ECEPQKLAAA LLPLLANGKT SHAMHDTFRE 360
  361 LHQQIRCNAD EQAAQAVLEL AQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.522879
Match:	1o6cA
Description:	Crystal structure of UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity, transferring hexosyl groups	3.04530122157712	bayes_pls_golite062009
catalytic activity	3.02192459767177	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	2.94500176353224	bayes_pls_golite062009
glycogen phosphorylase activity	2.09116455393465	bayes_pls_golite062009
lipopolysaccharide heptosyltransferase activity	2.03374890992046	bayes_pls_golite062009
glucosyltransferase activity	1.8062586862583	bayes_pls_golite062009
transferase activity	1.67770954408305	bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity	1.63103907245982	bayes_pls_golite062009
UDP-glucosyltransferase activity	1.4199532885636	bayes_pls_golite062009
UDP-glycosyltransferase activity	1.30934991061674	bayes_pls_golite062009
glycogen (starch) synthase activity	0.435616523537281	bayes_pls_golite062009
phosphorylase activity	0.431662083250969	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.27693350081385	bayes_pls_golite062009
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity	0.22009679964126	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: