YRC Public Data Repository - Protein Structure Prediction

Protein:	KHSE_ECOLI
Organism:	Escherichia coli
Length:	310 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KHSE_ECOLI.

Description	E-value	Query Range	Subject Range
KHSE_ECO57 - Homoserine kinase OS=Escherichia coli O157:H7 GN=thrB PE=3 SV=1 gi\|217320485, gi... - gi\|217324264\|ref\|ZP_03440348.1\| homoserine kinase [Escherichia coli O157:H7 str. TW14588], gi\|217320... gi\|13359459, gi\|... - gi\|15829257\|ref\|NP_308030.1\| homoserine kinase [Escherichia coli O157:H7 str. Sakai], gi\|13359459\|db... KHSE_ECO5E - Homoserine kinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=thrB PE=3 SV=1 gi\|254791139, gi... - gi\|254791139\|ref\|YP_003075976.1\| homoserine kinase [Escherichia coli O157:H7 str. TW14359], gi\|25459... gi\|168797981, gi... - gi\|189379603\|gb\|EDU98019.1\| homoserine kinase [Escherichia coli O157:H7 str. EC508], gi\|168797981\|re... gi\|168785051, gi... - gi\|189374945\|gb\|EDU93361.1\| homoserine kinase [Escherichia coli O157:H7 str. EC869], gi\|168785051\|re... gi\|189000731, gi... - gi\|189000731\|gb\|EDU69717.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4076], gi\|168781698\|r... gi\|168776613, gi... - gi\|187768016\|gb\|EDU31860.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4196], gi\|168776613\|r... gi\|208738789, gi... - gi\|208818666\|ref\|ZP_03258986.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4042], gi\|2087387... gi\|208735698, gi... - gi\|208814421\|ref\|ZP_03255750.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4045], gi\|2087356... gi\|208807589, gi... - gi\|208807589\|ref\|ZP_03249926.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4206], gi\|2087273... gi\|195937676 - gi\|195937676\|ref\|ZP_03083058.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4024] gi\|168766690, gi... - gi\|189364315\|gb\|EDU82734.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4486], gi\|168766690\|r... gi\|168762761, gi... - gi\|189366944\|gb\|EDU85360.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4501], gi\|168762761\|r... gi\|189356095, gi... - gi\|189356095\|gb\|EDU74514.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4401], gi\|168756826\|r... gi\|188014926, gi... - gi\|188014926\|gb\|EDU53048.1\| homoserine kinase [Escherichia coli O157:H7 str. EC4113], gi\|168750955\|r... gi\|12512678, gi\|... - gi\|15799683\|ref\|NP_285695.1\| homoserine kinase [Escherichia coli O157:H7 EDL933], gi\|12512678\|gb\|AAG... gi\|209747306, gi... - pir\|\|C85480 homoserine kinase [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pir...	280.0	[0..1]	[310..1]
KHSE_ECOUT - Homoserine kinase OS=Escherichia coli (strain UTI89 / UPEC) GN=thrB PE=3 SV=1 KHSE_ECO8A - Homoserine kinase OS=Escherichia coli O8 (strain IAI1) GN=thrB PE=3 SV=1 KHSE_ECOLC - Homoserine kinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=thrB PE=3 SV=1 KHSE_ECO45 - Homoserine kinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=thrB PE=3 SV=1 gi\|124530372, gi... - gi\|124530372\|ref\|ZP_01701058.1\| homoserine kinase [Escherichia coli B], gi\|124499263\|gb\|EAY46755.1\| ... gi\|194434152, gi... - gi\|194434152\|ref\|ZP_03066420.1\| homoserine kinase [Shigella dysenteriae 1012], gi\|194417589\|gb\|EDX33... KHSE_ECOK1 - Homoserine kinase OS=Escherichia coli O1:K1 / APEC GN=thrB PE=3 SV=1 KHSE_ECO27 - Homoserine kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thrB PE=3 SV=1 KHSE_ECO55 - Homoserine kinase OS=Escherichia coli (strain 55989 / EAEC) GN=thrB PE=3 SV=1 KHSE_ECO7I - Homoserine kinase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=thrB PE=3 SV=1 sp\|B7UI48\|KHSE_ECO27 - Homoserine kinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=thrB PE=3 SV=1 KHSE_SHIB3 - Homoserine kinase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=thrB PE=3 SV=1 KHSE_ECO24 - Homoserine kinase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=thrB PE=3 SV=1 gi\|75229463, gi\|... - gi\|75229463\|ref\|ZP_00716013.1\| COG0083: Homoserine kinase [Escherichia coli B7A], gi\|191167386\|ref\|Z... gi\|193070623, gi... - gi\|75234566\|ref\|ZP_00718907.1\| COG0083: Homoserine kinase [Escherichia coli E110019], gi\|193070623\|r... KHSE_ECOHS - Homoserine kinase OS=Escherichia coli O9:H4 (strain HS) GN=thrB PE=3 SV=1 gi\|194429160, gi... - gi\|75209607\|ref\|ZP_00709825.1\| COG0083: Homoserine kinase [Escherichia coli B171], gi\|194429160\|ref\|... KHSE_SHIDS - Homoserine kinase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=thrB PE=3 SV=1 KHSE_SHIBS - Homoserine kinase OS=Shigella boydii serotype 4 (strain Sb227) GN=thrB PE=3 SV=1 gi\|75256315, gi\|... - gi\|75256315\|ref\|ZP_00727987.1\| COG0083: Homoserine kinase [Escherichia coli E22], gi\|193065645\|ref\|Z... gi\|251783567, gi... - gi\|251783567\|ref\|YP_002997871.1\| hypothetical protein B21_00003 [Escherichia coli BL21], gi\|24237584... gi\|75515595, gi\|... - gi\|75515595\|ref\|ZP_00737752.1\| COG0083: Homoserine kinase [Escherichia coli 53638], gi\|188492615\|ref... gi\|226902053, gi... - gi\|237704141\|ref\|ZP_04534622.1\| homoserine kinase [Escherichia sp. 3_2_53FAA], gi\|226902053\|gb\|EEH88... gi\|253972025, gi... - gi\|254160126\|ref\|YP_003043232.1\| homoserine kinase [Escherichia coli B str. REL606], gi\|253972025\|gb... gi\|254286930, gi... - gi\|254286930\|ref\|YP_003052676.1\| homoserine kinase [Escherichia coli BL21(DE3)], gi\|253976235\|gb\|ACT...	279.0	[0..1]	[310..1]
gi\|190906586, gi... - gi\|75239532\|ref\|ZP_00723502.1\| COG0083: Homoserine kinase [Escherichia coli F11], gi\|191173201\|ref\|Z... KHSE_ECOL5 - Homoserine kinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=thrB PE=3 SV=1	279.0	[0..1]	[310..1]
KHSE_ECOL6 - Homoserine kinase OS=Escherichia coli O6 GN=thrB PE=3 SV=1 KHSE_ECOL6 - Homoserine kinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=thrB PE=3 SV=1 gi\|227837932, gi... - gi\|227885103\|ref\|ZP_04002908.1\| homoserine kinase [Escherichia coli 83972], gi\|227837932\|gb\|EEJ48398...	279.0	[0..1]	[310..1]
gi\|30061574, gi\|... - gi\|30061574\|ref\|NP_835745.1\| homoserine kinase [Shigella flexneri 2a str. 2457T], gi\|30039816\|gb\|AAP... gi\|24111453, gi\|... - gi\|24111453\|ref\|NP_705963.1\| homoserine kinase [Shigella flexneri 2a str. 301], gi\|24050201\|gb\|AAN41... KHSE_SHIFL - Homoserine kinase OS=Shigella flexneri GN=thrB PE=3 SV=1 KHSE_SHIF8 - Homoserine kinase OS=Shigella flexneri serotype 5b (strain 8401) GN=thrB PE=3 SV=1	278.0	[0..1]	[310..1]
KHSE_SHISS - Homoserine kinase OS=Shigella sonnei (strain Ss046) GN=thrB PE=3 SV=1	277.0	[0..1]	[310..1]
KHSE_SALTY - Homoserine kinase OS=Salmonella typhimurium GN=thrB PE=3 SV=1 KHSE_SALPK - Homoserine kinase OS=Salmonella paratyphi A (strain AKU_12601) GN=thrB PE=3 SV=1 KHSE_SALTY - Homoserine kinase OS=Salmonella typhimurium GN=thrB PE=3 SV=1 KHSE_SALG2 - Homoserine kinase OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=thrB PE=3 SV=1 KHSE_SALEP - Homoserine kinase OS=Salmonella enteritidis PT4 (strain P125109) GN=thrB PE=3 SV=1 gi\|213163205 - gi\|213163205\|ref\|ZP_03348915.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi... gi\|238910759 - gi\|238910759\|ref\|ZP_04654596.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Tenne... KHSE_SALHS - Homoserine kinase OS=Salmonella heidelberg (strain SL476) GN=thrB PE=3 SV=1 gi\|194456177, gi... - gi\|194469813\|ref\|ZP_03075797.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Kentu... KHSE_SALCH - Homoserine kinase OS=Salmonella choleraesuis GN=thrB PE=3 SV=1 KHSE_SALSV - Homoserine kinase OS=Salmonella schwarzengrund (strain CVM19633) GN=thrB PE=3 SV=1 KHSE_SALTI - Homoserine kinase OS=Salmonella typhi GN=thrB PE=3 SV=1 KHSE_SALA4 - Homoserine kinase OS=Salmonella agona (strain SL483) GN=thrB PE=3 SV=1 gi\|168244495, gi... - gi\|205336660\|gb\|EDZ23424.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Heidelber... gi\|168262341, gi... - gi\|205348959\|gb\|EDZ35590.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Hadar str... gi\|195632948, gi... - gi\|195632948\|gb\|EDX51402.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Newport s... KHSE_SALNS - Homoserine kinase OS=Salmonella newport (strain SL254) GN=thrB PE=3 SV=1 gi\|205323102, gi... - gi\|205323102\|gb\|EDZ10941.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Saintpaul... gi\|205331290, gi... - gi\|205331290\|gb\|EDZ18054.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar 4,[5],12:... gi\|197291870, gi... - gi\|197291870\|gb\|EDY31220.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Schwarzen... KHSE_SALTI - Homoserine kinase OS=Salmonella typhi GN=thrB PE=3 SV=1 KHSE_SALCH - Homoserine kinase OS=Salmonella choleraesuis (strain SC-B67) GN=thrB PE=3 SV=1 KHSE_SALPA - Homoserine kinase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=thrB PE=3 SV=1 gi\|16758996 - gi\|16758996\|ref\|NP_454613.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi st... KHSE_SALTY - Homoserine kinase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=thrB PE=3 SV=1 gi\|29136170, gi\|... - gi\|29140546\|ref\|NP_803888.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi st... KHSE_SALPC - Homoserine kinase OS=Salmonella paratyphi C (strain RKS4594) GN=thrB PE=3 SV=1 gi\|213426522 - gi\|213426522\|ref\|ZP_03359272.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi... gi\|213649305 - gi\|213649305\|ref\|ZP_03379358.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi... gi\|213865408 - gi\|213865408\|ref\|ZP_03387527.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi... lcl\|NC_016856.1_... - [gene=thrB] [protein=homoserine kinase] [protein_id=YP_005235636.1] [location=2801..3730] gi\|214001215 - gi\|214001215\|ref\|ZP_03411950.1\| homoserine kinase [Salmonella enterica subsp. enterica serovar Typhi... KHSE_SALPA - Homoserine kinase OS=Salmonella paratyphi A GN=thrB PE=3 SV=1 KHSE_SALCH - Homoserine kinase OS=Salmonella choleraesuis GN=thrB PE=3 SV=1	273.0	[0..1]	[308..1]
gi\|77976165 - gi\|77976165\|ref\|ZP_00831698.1\| COG0083: Homoserine kinase [Yersinia frederiksenii ATCC 33641]	268.0	[0..1]	[308..8]
KHSE_PECAS - Homoserine kinase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=thrB PE=3 SV=1 KHSE_ERWCT - Homoserine kinase OS=Erwinia carotovora subsp. atroseptica GN=thrB PE=3 SV=1	268.0	[0..1]	[306..1]
KHSE_SERMA - Homoserine kinase OS=Serratia marcescens GN=thrB PE=3 SV=1	267.0	[0..1]	[308..1]

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Predicted Domain #1

Region A:
Residues: [1-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKVYAPASS ANMSVGFDVL GAAVTPVDGA LLGDVVTVEA AETFSLNNLG RFADKLPSEP  60
   61 RENIVYQCWE RFCQELGKQI PVAMTLEKNM PIGSGLGSSA CSVVAALMAM NEHCGKPLND 120
  121 TRLLALMGEL EGRISGSIHY DNVAPCFLGG MQLMIEENDI ISQQVPGFDE WLWVLAYPGI 180
  181 KVSTAEARAI LPAQYRRQDC IAHGRHLAGF IHACYSRQPE LAAKLMKDVI AEPYRERLLP 240
  241 GFRQARQAVA EIGAVASGIS GSGPTLFALC DKPETAQRVA DWLGKNYLQN QEGFVHICRL 300
  301 DTAGARVLEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.39794
Match:	1fwkA
Description:	Homoserine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
homoserine kinase activity	2.13523123963453	bayes_pls_golite062009
catalytic activity	1.20658247466773	bayes_pls_golite062009
amino acid kinase activity	0.292543190343241	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: