YRC Public Data Repository - Protein Structure Prediction

Protein:	KGTP_ECOLI
Organism:	Escherichia coli
Length:	432 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KGTP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|67536615, gi\|... - gi\|67542336\|ref\|ZP_00420273.1\| General substrate transporter:Major facilitator superfamily [Burkhold...	244.0	[0..2]	[432..258]
gi\|50085380, gi\|... - gi\|50085380\|ref\|YP_046890.1\| proline/glycine betaine transporter [Acinetobacter sp. ADP1], gi\|495313...	222.0	[0..29]	[432..42]
gi\|50120481, gi\|... - gi\|50120481\|ref\|YP_049648.1\| proline/glycine betaine transporter [Pectobacterium atrosepticum SCRI10...	219.0	[0..16]	[432..20]
gi\|237703699, gi... - gi\|237703699\|ref\|ZP_04534180.1\| proline/glycine betaine transporter [Escherichia sp. 3_2_53FAA], gi\|... gi\|91075232, gi\|... - gi\|91213658\|ref\|YP_543644.1\| proline/glycine betaine transporter [Escherichia coli UTI89], gi\|910752... gi\|26250926, gi\|... - gi\|26250926\|ref\|NP_756966.1\| proline/glycine betaine transporter [Escherichia coli CFT073], gi\|26111...	218.0	[0..18]	[432..32]
gi\|254215795, gi... - gi\|254264793\|ref\|ZP_04955658.1\| MFS transporter, metabolite:H+ symporter (MHS) family protein [Burkh... gi\|76583741, gi\|... - gi\|76819268\|ref\|YP_336728.1\| alpha-ketoglutarate permease [Burkholderia pseudomallei 1710b], gi\|7658...	218.0	[0..3]	[432..200]
gi\|218367969, gi... - gi\|218561200\|ref\|YP_002394113.1\| proline/glycine betaine transporter [Escherichia coli S88], gi\|2183... gi\|218429971, gi... - gi\|218692407\|ref\|YP_002400619.1\| proline/glycine betaine transporter [Escherichia coli ED1a], gi\|218... gi\|115515522, gi... - gi\|117626398\|ref\|YP_859721.1\| proline/glycine betaine transporter [Escherichia coli APEC O1], gi\|115... gi\|227886851, gi... - gi\|227886851\|ref\|ZP_04004656.1\| proline/glycine betaine transporter [Escherichia coli 83972], gi\|227...	216.0	[0..18]	[432..21]
gi\|1661219 - gi\|1661219\|gb\|AAC44538.1\| ProP [Escherichia coli]	216.0	[0..18]	[432..21]
gi\|163862954, gi... - gi\|89207137\|ref\|ZP_01185684.1\| General substrate transporter:Major facilitator superfamily MFS_1 [Ba...	215.0	[0..17]	[432..19]
gi\|92442343, gi\|... - gi\|92913081\|ref\|ZP_01281710.1\| General substrate transporter:Major facilitator superfamily MFS_1 [My...	215.0	[0..3]	[425..391]
gi\|75212040, gi\|... - gi\|75212040\|ref\|ZP_00712095.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|75197963, gi\|... - gi\|75197963\|ref\|ZP_00708033.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|157079181, gi... - gi\|75188827\|ref\|ZP_00702094.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|209921600, gi... - gi\|209921600\|ref\|YP_002295684.1\| proline/glycine betaine transporter [Escherichia coli SE11], gi\|209... gi\|218363432, gi... - gi\|218556663\|ref\|YP_002389577.1\| proline/glycine betaine transporter [Escherichia coli IAI1], gi\|218... gi\|218697813, gi... - gi\|218697813\|ref\|YP_002405480.1\| proline/glycine betaine transporter [Escherichia coli 55989], gi\|21... gi\|193063071, gi... - gi\|75259030\|ref\|ZP_00730398.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|193067855, gi... - gi\|75238640\|ref\|ZP_00722629.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ... gi\|190904287, gi... - gi\|75231294\|ref\|ZP_00717701.1\| COG0477: Permeases of the major facilitator superfamily [Escherichia ...	214.0	[0..18]	[432..21]

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Predicted Domain #1

Region A:
Residues: [1-432]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAESTVTADS KLTSSDTRRR IWAIVGASSG NLVEWFDFYV YSFCSLYFAH IFFPSGNTTT  60
   61 QLLQTAGVFA AGFLMRPIGG WLFGRIADKH GRKKSMLLSV CMMCFGSLVI ACLPGYETIG 120
  121 TWAPALLLLA RLFQGLSVGG EYGTSATYMS EVAVEGRKGF YASFQYVTLI GGQLLALLVV 180
  181 VVLQHTMEDA ALREWGWRIP FALGAVLAVV ALWLRRQLDE TSQQETRALK EAGSLKGLWR 240
  241 NRRAFIMVLG FTAAGSLCFY TFTTYMQKYL VNTAGMHANV ASGIMTAALF VFMLIQPLIG 300
  301 ALSDKIGRRT SMLCFGSLAA IFTVPILSAL QNVSSPYAAF GLVMCALLIV SFYTSISGIL 360
  361 KAEMFPAQVR ALGVGLSYAV ANAIFGGSAE YVALSLKSIG METAFFWYVT LMAVVAFLVS 420
  421 LMLHRKGKGM RL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.221849
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
binding	0.805286077372817	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: