YRC Public Data Repository - Protein Structure Prediction

Protein:	KCH_ECOLI
Organism:	Escherichia coli
Length:	417 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KCH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|84500898, gi\|... - gi\|84500898\|ref\|ZP_00999133.1\| glutathione-regulated potassium-efflux system protein [Oceanicola bat...	191.0	[0..16]	[405..197]
gi\|84664598, gi\|... - gi\|84687440\|ref\|ZP_01015318.1\| glutathione-regulated potassium-efflux system protein [Rhodobacterale...	185.0	[0..16]	[405..184]
gi\|90578110, gi\|... - gi\|90578110\|ref\|ZP_01233921.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio an...	183.0	[0..22]	[397..198]
gi\|86144348, gi\|... - gi\|86144348\|ref\|ZP_01062680.1\| glutathione-regulated potassium-efflux system protein KefC [Vibrio sp...	182.0	[0..22]	[384..198]
gi\|84717301, gi\|... - gi\|84717301\|ref\|ZP_01023482.1\| Potassium efflux system protein [Polaromonas naphthalenivorans CJ2], ...	182.0	[0..20]	[404..211]
gi\|68181979, gi\|... - gi\|89055795\|ref\|YP_511246.1\| sodium/hydrogen exchanger [Jannaschia sp. CCS1], gi\|88865344\|gb\|ABD5622...	182.0	[0..16]	[411..217]
gi\|109455239, gi... - gi\|110679123\|ref\|YP_682130.1\| glutathione-regulated potassium-efflux system protein [Roseobacter den...	181.0	[0..16]	[416..199]
gi\|121628724, gi... - gi\|121729001\|ref\|ZP_01682004.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio c... gi\|11278405 - pir\|\|B82056 glutathione-regulated potassium-efflux system protein KefB VC2606 [imported] - Vibrio ch... gi\|125619162, gi... - gi\|254851146\|ref\|ZP_05240496.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio c... gi\|229516859, gi... - gi\|229516859\|ref\|ZP_04406305.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio c... gi\|229369503, gi... - gi\|229606848\|ref\|YP_002877496.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio ... gi\|227082723, gi... - gi\|227082723\|ref\|YP_002811274.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio ... gi\|15642601, gi\|... - gi\|9657194\|gb\|AAF95747.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio cholera... gi\|229507342, gi... - gi\|229507342\|ref\|ZP_04396847.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio c... gi\|150423984, gi... - gi\|254285802\|ref\|ZP_04960764.1\| glutathione-regulated potassium-efflux system protein KefB [Vibrio c...	181.0	[0..34]	[405..246]
gi\|75214431 - gi\|75214431\|ref\|ZP_00713040.1\| COG0475: Kef-type K+ transport systems, membrane components [Escheric...	181.0	[0..31]	[416..63]
gi\|28900319, gi\|... - gi\|28900319\|ref\|NP_799974.1\| putative TrkA family protein [Vibrio parahaemolyticus RIMD 2210633], gi... gi\|28808630 - gi\|28808630\|dbj\|BAC61807.1\| putative TrkA family protein [Vibrio parahaemolyticus RIMD 2210633]	181.0	[0..20]	[400..196]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHWATFKQT ATNLWVTLRH DILALAVFLN GLLIFKTIYG MSVNLLDIFH IKAFSELDLS  60
   61 LLANAPLFML GVFLVLNSIG LLFRAKLAWA ISIILLLIAL IYTLHFYPWL KFSIGFCIFT 120
  121 LVFLLILRKD FSHSSAAAGT IFAFISFTTL LFYSTYGALY LSEGFNPRIE SLMTAFYFSI 180
  181 ETMSTVGYGD IVPVSESARL FTISVIISGI TVFATSMTSI FGPLIRGGFN KLVKGNNHTM 240
  241 HRKDHFIVCG HSILAINTIL QLNQRGQNVT VISNLPEDDI KQLEQR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	36.221849
Match:	2a79B
Description:	Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [287-417]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGDNADVIPG DSNDSSVLKK AGIDRCRAIL ALSDNDADNA FVVLSAKDMS SDVKTVLAVS  60
   61 DSKNLNKIKM VHPDIILSPQ LFGSEILARV LNGEEINNDM LVSMLLNSGH GIFSDNDELE 120
  121 TKADSKESAQ K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.39794
Match:	1id1A
Description:	Rck domain from putative potassium channel Kch
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.40143066098294	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.794265596378362	bayes_pls_golite062009
potassium ion transmembrane transporter activity	0.7917593970345	bayes_pls_golite062009
cation transmembrane transporter activity	0.667941911014379	bayes_pls_golite062009
ion transmembrane transporter activity	0.644377496622781	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.455628854268609	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.439757800700606	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.189869347204878	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: