YRC Public Data Repository - Protein Structure Prediction

Protein:	INTF_ECOLI
Organism:	Escherichia coli
Length:	466 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for INTF_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77974232, gi\|... - gi\|77974232\|ref\|ZP_00829773.1\| COG0582: Integrase [Yersinia frederiksenii ATCC 33641], gi\|238790928\|...	245.0	[0..31]	[465..1]
gi\|190902162, gi... - gi\|75229050\|ref\|ZP_00715634.1\| COG0582: Integrase [Escherichia coli B7A], gi\|191167819\|ref\|ZP_030296...	241.0	[0..31]	[464..1]
gi\|77962153, gi\|... - gi\|77962153\|ref\|ZP_00825977.1\| COG0582: Integrase [Yersinia mollaretii ATCC 43969], gi\|238795435\|ref...	241.0	[0..31]	[460..1]
gi\|253975488, gi... - gi\|254163587\|ref\|YP_003046695.1\| Int [Escherichia coli B str. REL606], gi\|253975488\|gb\|ACT41159.1\| I... gi\|194435929, gi... - gi\|83588494\|ref\|ZP_00927118.1\| COG0582: Integrase [Escherichia coli 101-1], gi\|194435929\|ref\|ZP_0306... gi\|57545625 - gi\|57545625\|gb\|AAW51716.1\| Int [Escherichia coli] gi\|26250313, gi\|... - gi\|26250313\|ref\|NP_756353.1\| putative prophage integrase [Escherichia coli CFT073], gi\|26110743\|gb\|A... gi\|251786909, gi... - gi\|251786909\|ref\|YP_003001213.1\| hypothetical protein B21_03468 [Escherichia coli BL21], gi\|24237918... gi\|254290337, gi... - gi\|254290337\|ref\|YP_003056085.1\| Int [Escherichia coli BL21(DE3)], gi\|253979644\|gb\|ACT45314.1\| Int [...	237.0	[0..31]	[458..1]
gi\|75194504, gi\|... - gi\|75194504\|ref\|ZP_00704574.1\| COG0582: Integrase [Escherichia coli HS], gi\|157159783\|ref\|YP_0014571...	237.0	[0..31]	[458..1]
gi\|14252927 - gi\|14252927\|emb\|CAC39282.1\| integrase [Escherichia coli]	237.0	[0..31]	[458..1]
gi\|74314106, gi\|... - gi\|74314106\|ref\|YP_312525.1\| putative integrase [Shigella sonnei Ss046], gi\|73857583\|gb\|AAZ90290.1\| ...	235.0	[0..31]	[458..1]
gi\|28872456, gi\|... - gi\|28872456\|ref\|NP_795075.1\| phage integrase family site specific recombinase [Pseudomonas syringae ... tr\|Q87UF4\|Q87UF4... - Site-specific recombinase, phage integrase family OS=Pseudomonas syringae pv. tomato (strain DC3000)...	235.0	[0..31]	[466..1]
gi\|87307430, gi\|... - gi\|87307430\|ref\|ZP_01089574.1\| probable cp4-like integrase protein [Blastopirellula marina DSM 3645]...	235.0	[0..31]	[458..1]
gi\|110617213, gi... - gi\|110807665\|ref\|YP_691185.1\| putative integrase [Shigella flexneri 5 str. 8401], gi\|110617213\|gb\|AB... gi\|11278380, gi\|... - gi\|5532446\|gb\|AAD44730.1\|AF141323_1 Int [Shigella flexneri], pir\|\|T44463 integrase int [imported] - ...	234.0	[0..31]	[458..1]

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Predicted Domain #1

Region A:
Residues: [1-154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFIPSIYLHQ QLHYCKTAIL NWSRKMALSR QKFTFERLRR FTLPEGKKQT FLWDADVTTL  60
   61 ACRATSGAKA FVFQSVYAGK TLRMTIGNIN DWKIDDARAE ARRLQTLIDT GIDPRIAKAV 120
  121 KIAEAESLQA ESRKTKVTFS VAWEDYLQEL RTGI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.702	0.035	DNA binding	d.129.1	TATA-box binding protein-like
View	Download	0.836	0.018	DNA integration	d.110.1	Profilin (actin-binding protein)
View	Download	0.837	N/A	N/A	d.105.1	Clathrin adaptor appendage, alpha and beta chain-specific domain
View	Download	0.821	N/A	N/A	d.110.1	Profilin (actin-binding protein)
View	Download	0.776	N/A	N/A	d.105.1	Clathrin adaptor appendage, alpha and beta chain-specific domain

Predicted Domain #2

Region A:
Residues: [155-466]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAKTKRPYST RYIADHINLS SRGGESKKRG QGPTSAGPLA SLLNLPLSEL TPDYIAAWLS  60
   61 TERQNRPTVT AHAYRLLRAF IKWSNYQKKY QGIIPGDLAQ DYNVRKMVPV SASKADDCLQ 120
  121 KEQLKSWFSA VRSLNNPIAS AYLQVLLLTG ARREEIASLR WSDVDFKWSS MRIKDKIEGE 180
  181 RIIPLTPYVS ELLNVLAQSP NSDVNKEGWV FRSNSKSGKI IEPRSAHNRA LVLAELPHIS 240
  241 LHGLRRSFGT LAEWVEVPTG IVAQIMGHKP SALAEKHYRR RPLDLLRKWH EKIETWILNE 300
  301 AGITIKNNVD MR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.69897
Match:	1a0pA
Description:	SITE-SPECIFIC RECOMBINASE, XERD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.32470898553998	bayes_pls_golite062009
site-specific recombinase activity	0.63725674285826	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: