YRC Public Data Repository - Protein Structure Prediction

Protein:	IMDH2_CRIGR
Organism:	Cricetulus griseus
Length:	514 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IMDH2_CRIGR.

Description	E-value	Query Range	Subject Range
gi\|82500120, gi\|... - gi\|82500120\|ref\|ZP_00885547.1\| IMP dehydrogenase [Caldicellulosiruptor saccharolyticus DSM 8903], gi...	489.0	[0..22]	[511..4]
IMDH_AQUAE - Inosine-5'-monophosphate dehydrogenase OS=Aquifex aeolicus GN=guaB PE=3 SV=1 IMDH_AQUAE - Inosine-5'-monophosphate dehydrogenase OS=Aquifex aeolicus (strain VF5) GN=guaB PE=3 SV=1	485.0	[0..24]	[511..6]
gi\|166853413, gi... - gi\|167039173\|ref\|YP_001662158.1\| response regulator receiver protein [Thermoanaerobacter sp. X514], ... gi\|167038115, gi... - gi\|76796702\|ref\|ZP_00779057.1\| IMP dehydrogenase [Thermoanaerobacter ethanolicus ATCC 33223], gi\|765... gi\|241902681, gi... - gi\|241902681\|ref\|ZP_04787413.1\| inosine-5'-monophosphate dehydrogenase [Thermoanaerobacter brockii s...	483.0	[0..22]	[511..2]
gi\|20807078, gi\|... - gi\|20807078\|ref\|NP_622249.1\| IMP dehydrogenase/GMP reductase [Thermoanaerobacter tengcongensis MB4],... gi\|20807078 - gi\|20807078\|ref\|NP_622249.1\| IMP dehydrogenase/GMP reductase [Thermoanaerobacter tengcongensis MB4]	480.0	[0..22]	[511..2]
gi\|56418544, gi\|... - gi\|56418544\|ref\|YP_145862.1\| inositol-5-monophosphate dehydrogenase [Geobacillus kaustophilus HTA426... gi\|229328469, gi... - gi\|229500654\|ref\|ZP_04394306.1\| inosine-5'-monophosphate dehydrogenase [Geobacillus sp. Y412MC52], g... gi\|220706074, gi... - gi\|221090011\|ref\|ZP_03559507.1\| inosine-5'-monophosphate dehydrogenase [Geobacillus sp. Y412MC61], g...	476.0	[0..20]	[511..1]
gi\|25284006 - pir\|\|D97232 IMP dehydrogenase (EC 1.1.1.205) [similarity] - Clostridium acetobutylicum gi\|15025734, gi\|... - gi\|15895958\|ref\|NP_349307.1\| inositol-5-monophosphate dehydrogenase [Clostridium acetobutylicum ATCC...	474.0	[0..22]	[511..1]
gi\|60098399, gi\|... - gi\|71895387\|ref\|NP_001025772.1\| inosine monophosphate dehydrogenase 2 [Gallus gallus], gi\|60098399\|e...	473.0	[0..1]	[514..1]
gi\|78042653, gi\|... - gi\|78042653\|ref\|YP_360021.1\| inosine-5'-monophosphate dehydrogenase [Carboxydothermus hydrogenoforma...	473.0	[0..22]	[511..2]
gi\|28204441, gi\|... - gi\|28211998\|ref\|NP_782942.1\| inositol-5-monophosphate dehydrogenase [Clostridium tetani E88], gi\|282...	472.0	[0..22]	[511..1]
gi\|85712714, gi\|... - gi\|85712714\|ref\|ZP_01043759.1\| inositol-5-monophosphate dehydrogenase [Idiomarina baltica OS145], gi...	472.0	[0..22]	[511..1]

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Predicted Domain #1

Region A:
Residues: [1-514]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT  60
   61 LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 120
  121 LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDRFLEEIMT 180
  181 KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNENDELVA IIARTDLKKN RDYPLASKDA 240
  241 KKQLLCGAAI GTHEDDKYRL DLLALAGVDV VVLDSSQGNS IFQINMIKYM KEKYPNLQVI 300
  301 GGNVVTAAQA KNLIDAGVDA LRVGMGCGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 360
  361 VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 420
  421 DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 480
  481 AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	133.0
Match:	1b3oA
Description:	Inosine monophosphate dehydrogenase (IMPDH)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
IMP dehydrogenase activity	2.02048863053452	bayes_pls_golite062009
binding	0.964202692685807	bayes_pls_golite062009
transporter activity	0.961062314616209	bayes_pls_golite062009
transmembrane transporter activity	0.807029018941177	bayes_pls_golite062009
substrate-specific transporter activity	0.640881170978843	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.525366315833255	bayes_pls_golite062009
ion transmembrane transporter activity	0.440262824681055	bayes_pls_golite062009
protein binding	0.22179604283012	bayes_pls_golite062009
catalytic activity	0.181756622780318	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	0.0973526732376297	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: