YRC Public Data Repository - Protein Structure Prediction

Protein:	HYCG_ECOLI
Organism:	Escherichia coli
Length:	255 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HYCG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115514075, gi... - gi\|117624951\|ref\|YP_853939.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escherich... gi\|170683663, gi... - gi\|170683663\|ref\|YP_001744868.1\| formate hydrogenlyase, subunit G [Escherichia coli SMS-3-5], gi\|170... gi\|75256921, gi\|... - gi\|75256921\|ref\|ZP_00728497.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli E22], ... gi\|191171381, gi... - gi\|75241663\|ref\|ZP_00725500.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli F11], ... gi\|218555263, gi... - gi\|218555263\|ref\|YP_002388176.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|227834526, gi... - gi\|227888257\|ref\|ZP_04006062.1\| hydrogenase activity [Escherichia coli 83972], gi\|227834526\|gb\|EEJ44... gi\|75235686, gi\|... - gi\|75235686\|ref\|ZP_00719860.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli E11001... gi\|209920158, gi... - gi\|209920158\|ref\|YP_002294242.1\| formate hydrogenlyase subunit [Escherichia coli SE11], gi\|209913417... gi\|226899698, gi... - gi\|237706658\|ref\|ZP_04537139.1\| formate hydrogenlyase subunit 7 [Escherichia sp. 3_2_53FAA], gi\|2268... gi\|191166819, gi... - gi\|75230075\|ref\|ZP_00716585.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli B7A], ... gi\|218690843, gi... - gi\|218690843\|ref\|YP_002399055.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|75210920, gi\|... - gi\|75210920\|ref\|ZP_00711044.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli B171],... gi\|91212079, gi\|... - gi\|91212079\|ref\|YP_542065.1\| formate hydrogenlyase subunit 7 [Escherichia coli UTI89], gi\|91073653\|g... gi\|218559709, gi... - gi\|218559709\|ref\|YP_002392622.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|157157238, gi... - gi\|75187441\|ref\|ZP_00700708.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli E24377... gi\|110642842, gi... - gi\|110642842\|ref\|YP_670572.1\| formate hydrogenlyase-3 component G [Escherichia coli 536], gi\|1103444... gi\|218706213, gi... - gi\|218706213\|ref\|YP_002413732.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|218371197, gi... - gi\|218701211\|ref\|YP_002408840.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|26249118, gi\|... - gi\|26249118\|ref\|NP_755158.1\| formate hydrogenlyase subunit 7 [Escherichia coli CFT073], gi\|26109525\|...	257.0	[0..1]	[255..1]
gi\|194422109, gi... - gi\|83585622\|ref\|ZP_00924265.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Escherichia coli 101-1]... gi\|242378276, gi... - gi\|251786003\|ref\|YP_003000307.1\| hypothetical protein B21_02534 [Escherichia coli BL21], gi\|24237827... gi\|208726707, gi... - gi\|208806906\|ref\|ZP_03249243.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC42... gi\|253772426, gi... - gi\|254289411\|ref\|YP_003055159.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|208733883, gi... - gi\|208812606\|ref\|ZP_03253935.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC40... gi\|253974551, gi... - gi\|254162650\|ref\|YP_003045758.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|208818509, gi... - gi\|208818509\|ref\|ZP_03258829.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC40... gi\|254794659, gi... - gi\|254794659\|ref\|YP_003079496.1\| hydrogenase 3 and formate hydrogenase complex, HycG subunit [Escher... gi\|209158135, gi... - gi\|209396735\|ref\|YP_002272182.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4... gi\|217327730, gi... - gi\|217327730\|ref\|ZP_03443813.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. TW14... gi\|15832829, gi\|... - gi\|15832829\|ref\|NP_311602.1\| formate hydrogenlyase subunit-7 component G [Escherichia coli O157:H7 s... gi\|189357334, gi... - gi\|189357334\|gb\|EDU75753.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4401],... gi\|168762882, gi... - gi\|189366866\|gb\|EDU85282.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4501],... gi\|189362033, gi... - gi\|189362033\|gb\|EDU80452.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4486],... gi\|187769518, gi... - gi\|187769518\|gb\|EDU33362.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4196],... gi\|189003614, gi... - gi\|189003614\|gb\|EDU72600.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4076],... gi\|168787974, gi... - gi\|189372104\|gb\|EDU90520.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC869], ... gi\|189377479, gi... - gi\|189377479\|gb\|EDU95895.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC508], ... gi\|195938469 - gi\|195938469\|ref\|ZP_03083851.1\| formate hydrogenlyase subunit-7 component G [Escherichia coli O157:H... gi\|209761916, gi... - pir\|\|G91075 formate hydrogenlyase subunit-7 component G [imported] - Escherichia coli (strain O157:H... gi\|15803236, gi\|... - gi\|15803236\|ref\|NP_289268.1\| hydrogenase activity [Escherichia coli O157:H7 EDL933], gi\|12517167\|gb\|... gi\|15832829, gi\|... - gi\|15832829\|ref\|NP_311602.1\| formate hydrogenlyase subunit-7 component G [Escherichia coli O157:H7],... gi\|168749956, gi... - gi\|188015810\|gb\|EDU53932.1\| formate hydrogenlyase, subunit G [Escherichia coli O157:H7 str. EC4113],...	257.0	[0..1]	[255..1]
gi\|73856763, gi\|... - gi\|74313286\|ref\|YP_311705.1\| hydrogenase activity [Shigella sonnei Ss046], gi\|73856763\|gb\|AAZ89470.1...	257.0	[0..1]	[255..1]
gi\|83569918, gi\|... - gi\|83569918\|ref\|ZP_00921366.1\| COG3260: Ni,Fe-hydrogenase III small subunit [Shigella dysenteriae 10...	255.0	[0..1]	[255..1]
gi\|110616202, gi... - gi\|110806654\|ref\|YP_690174.1\| hydrogenase activity [Shigella flexneri 5 str. 8401], gi\|110616202\|gb\|...	255.0	[0..1]	[255..1]
gi\|1093500, gi\|41686 - gi\|41686\|emb\|CAA35552.1\| hycG [Escherichia coli], gi\|1093500\|prf\|\|2104213G hycG gene	253.0	[0..1]	[255..1]
gi\|82545206, gi\|... - gi\|82545206\|ref\|YP_409153.1\| hydrogenase activity [Shigella boydii Sb227], gi\|81246617\|gb\|ABB67325.1...	252.0	[0..1]	[255..1]
gi\|238909614 - gi\|238909614\|ref\|ZP_04653451.1\| formate hydrogenlyase subunit 7 [Salmonella enterica subsp. enterica... gi\|200388880, gi... - gi\|200388880\|ref\|ZP_03215492.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enteric... lcl\|NC_016856.1_... - [gene=hycG] [protein=hydrogenase] [protein_id=YP_005238951.1] [location=complement(3012810..3013577)... gi\|224584624, gi... - gi\|224584624\|ref\|YP_002638422.1\| formate hydrogenlyase subunit 7 [Salmonella enterica subsp. enteric... gi\|16766153, gi\|... - gi\|16766153\|ref\|NP_461768.1\| hydrogenase [Salmonella typhimurium LT2], gi\|16421393\|gb\|AAL21727.1\| hy... gi\|194734314, gi... - gi\|194734314\|ref\|YP_002115800.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enteri... gi\|197248973, gi... - gi\|197248973\|ref\|YP_002147745.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enteri... gi\|205342888, gi... - gi\|205342888\|gb\|EDZ29652.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|194448464, gi... - gi\|194448464\|ref\|YP_002046808.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enteri... gi\|205348984, gi... - gi\|205348984\|gb\|EDZ35615.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|168464027, gi... - gi\|195633447\|gb\|EDX51861.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|197290829, gi... - gi\|197290829\|gb\|EDY30183.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|205337969, gi... - gi\|205337969\|gb\|EDZ24733.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|167550313, gi... - gi\|205324705\|gb\|EDZ12544.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|167994151, gi... - gi\|205327917\|gb\|EDZ14681.1\| formate hydrogenlyase, subunit G [Salmonella enterica subsp. enterica se... gi\|161502108, gi... - gi\|161502108\|ref\|YP_001569220.1\| hypothetical protein SARI_00125 [Salmonella enterica subsp. arizona... gi\|161365114, gi... - gi\|161615750\|ref\|YP_001589715.1\| hypothetical protein SPAB_03541 [Salmonella enterica subsp. enteric... gi\|62181350, gi\|... - gi\|62181350\|ref\|YP_217767.1\| hydrogenase activity [Salmonella enterica subsp. enterica serovar Chole...	251.0	[0..1]	[255..1]
gi\|197363727, gi... - gi\|197363727\|ref\|YP_002143364.1\| formate hydrogenlyase subunit 7 [Salmonella enterica subsp. enteric... gi\|56129056, gi\|... - gi\|56414799\|ref\|YP_151874.1\| formate hydrogenlyase subunit 7 [Salmonella enterica subsp. enterica se...	250.0	[0..1]	[255..1]
gi\|110456608 - gi\|110456608\|gb\|ABG74735.1\| NADH dehydrogenase 32 kDa subunit [Forsythia europaea]	250.0	[0..1]	[243..1]

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Predicted Domain #1

Region A:
Residues: [1-187]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNLLGPRDA NGIPVPMTVD ESIASMKASL LKKIKRSAYV YRVDCGGCNG CEIEIFATLS  60
   61 PLFDAERFGI KVVPSPRHAD ILLFTGAVTR AMRSPALRAW QSAPDPKICI SYGACGNSGG 120
  121 IFHDLYCVWG GTDKIVPVDV YIPGCPPTPA ATLYGFAMAL GLLEQKIHAR GPGELDEQPA 180
  181 EILHGDM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.69897
Match:	2fug6
Description:	Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on hydrogen as donor	2.20752608202439	bayes_pls_golite062009
ferredoxin hydrogenase activity	1.32333392056778	bayes_pls_golite062009
oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	1.32333392056778	bayes_pls_golite062009
NADH dehydrogenase activity	0.84569674518508	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.554599825830849	bayes_pls_golite062009
catalytic activity	0.513070432311783	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	0.463241887648122	bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors	0.39909556472213	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	0.314635495446813	bayes_pls_golite062009
oxidoreductase activity	0.0918357876652069	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [188-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQPLRVKVDR EARRLAGYRY GRQIADDYLT QLGQGEEQVA RWLEAENDPR LNEIVSHLNH  60
   61 VVEEARIR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: