YRC Public Data Repository - Protein Structure Prediction

Protein:	HLDD_ECOLI
Organism:	Escherichia coli
Length:	310 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLDD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|7437238 - pir\|\|H69105 dTDP-glucose 4,6-dehydratase - Methanobacterium thermoautotrophicum (strain Delta H) gi\|15679777, gi\|... - gi\|2622920\|gb\|AAB86255.1\| dTDP-glucose 4,6-dehydratase [Methanothermobacter thermautotrophicus str. ...	294.0	[0..2]	[309..4]
gi\|41205692 - gi\|41205692\|gb\|AAR99612.1\| dTDP-glucose 4,6-dehydratase [Geobacillus stearothermophilus]	292.0	[0..2]	[309..5]
gi\|56459650, gi\|... - gi\|56459650\|ref\|YP_154931.1\| dTDP-D-glucose 4,6-dehydratase [Idiomarina loihiensis L2TR], gi\|5617866...	284.0	[0..2]	[309..3]
gi\|4240415 - gi\|4240415\|gb\|AAD13546.1\| NDP-hexose 4,6-dehydratase homolog [Streptomyces cyanogenus]	281.0	[0..2]	[309..4]
gi\|33413324, gi\|... - gi\|33413324\|emb\|CAD67949.1\| putative dTDP-glucose 4,6-dehydratase [Thermotoga sp. RQ2], gi\|170288108...	280.0	[0..2]	[309..3]
gi\|88800554, gi\|... - gi\|88800554\|ref\|ZP_01116116.1\| dTDP-glucose 4,6-dehydratase [Reinekea sp. MED297], gi\|88776699\|gb\|EA...	279.0	[0..3]	[309..7]
gi\|196111589, gi... - gi\|88795902\|ref\|ZP_01111591.1\| dTDP-glucose 4,6 dehydratase [Alteromonas macleodii 'Deep ecotype'], ...	278.0	[0..2]	[309..5]
gi\|51243897, gi\|... - gi\|51243897\|ref\|YP_063781.1\| dTDP-D-glucose-4,6-dehydratase [Desulfotalea psychrophila LSv54], gi\|50...	276.0	[0..2]	[309..20]
gi\|77810847, gi\|... - gi\|77814102\|ref\|ZP_00813368.1\| dTDP-glucose 4,6-dehydratase [Shewanella putrefaciens CN-32], gi\|7781...	276.0	[0..2]	[309..3]

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Predicted Domain #1

Region A:
Residues: [1-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIVTGGAGF IGSNIVKALN DKGITDILVV DNLKDGTKFV NLVDLNIADY MDKEDFLIQI  60
   61 MAGEEFGDVE AIFHEGACSS TTEWDGKYMM DNNYQYSKEL LHYCLEREIP FLYASSAATY 120
  121 GGRTSDFIES REYEKPLNVY GYSKFLFDEY VRQILPEANS QIVGFRYFNV YGPREGHKGS 180
  181 MASVAFHLNT QLNNGESPKL FEGSENFKRD FVYVGDVADV NLWFLENGVS GIFNLGTGRA 240
  241 ESFQAVADAT LAYHKKGQIE YIPFPDKLKG RYQAFTQADL TNLRAAGYDK PFKTVAEGVT 300
  301 EYMAWLNRDA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.0
Match:	1eq2A
Description:	ADP-L-glycero-D-mannoheptose 6-epimerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.824879127880521	bayes_pls_golite062009
retinol dehydrogenase activity	0.48941662111046	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: