YRC Public Data Repository - Protein Structure Prediction

Protein:	HFLK_ECOLI
Organism:	Escherichia coli
Length:	419 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HFLK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|82779444, gi\|... - gi\|82779444\|ref\|YP_405793.1\| FtsH protease regulator HflK [Shigella dysenteriae Sd197], gi\|81243592\|...	317.0	[0..1]	[419..1]
gi\|110644531, gi... - gi\|110644531\|ref\|YP_672261.1\| FtsH protease regulator HflK [Escherichia coli 536], gi\|110346123\|gb\|A... gi\|218692508, gi... - gi\|218692508\|ref\|YP_002400720.1\| FtsH protease regulator HflK [Escherichia coli ED1a], gi\|218430072\|... gi\|170520346, gi... - gi\|170682628\|ref\|YP_001746569.1\| HflK protein [Escherichia coli SMS-3-5], gi\|170520346\|gb\|ACB18524.1... gi\|218372857, gi... - gi\|218702871\|ref\|YP_002410500.1\| FtsH protease regulator HflK [Escherichia coli IAI39], gi\|218372857... gi\|190905198, gi... - gi\|75242437\|ref\|ZP_00726199.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|26251066, gi\|... - gi\|26251066\|ref\|NP_757106.1\| FtsH protease regulator HflK [Escherichia coli CFT073], gi\|26111498\|gb\|... gi\|227836356, gi... - gi\|227886783\|ref\|ZP_04004588.1\| FtsH protease regulator HflK [Escherichia coli 83972], gi\|227836356\|...	316.0	[0..1]	[419..1]
gi\|91075297, gi\|... - gi\|91213723\|ref\|YP_543709.1\| FtsH protease regulator HflK [Escherichia coli UTI89], gi\|91075297\|gb\|A... gi\|117626521, gi... - gi\|117626521\|ref\|YP_859844.1\| FtsH protease regulator HflK [Escherichia coli APEC O1], gi\|115515645\|... gi\|226901753, gi... - gi\|237703841\|ref\|ZP_04534322.1\| FtsH protease regulator HflK [Escherichia sp. 3_2_53FAA], gi\|2269017... gi\|218368102, gi... - gi\|218561333\|ref\|YP_002394246.1\| FtsH protease regulator HflK [Escherichia coli S88], gi\|218368102\|e...	316.0	[0..1]	[419..1]
gi\|191165677, gi... - gi\|75231233\|ref\|ZP_00717640.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|75212277, gi\|... - gi\|75212277\|ref\|ZP_00712317.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|193066027, gi... - gi\|75255901\|ref\|ZP_00727633.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|192955827, gi... - gi\|75234277\|ref\|ZP_00718665.1\| COG0330: Membrane protease subunits, stomatin/prohibitin homologs [Es... gi\|218697923, gi... - gi\|218697923\|ref\|YP_002405590.1\| FtsH protease regulator HflK [Escherichia coli 55989], gi\|218354655...	316.0	[0..1]	[419..1]
gi\|81247996, gi\|... - gi\|82546585\|ref\|YP_410532.1\| FtsH protease regulator HflK [Shigella boydii Sb227], gi\|81247996\|gb\|AB...	315.0	[0..1]	[419..1]
gi\|24115529, gi\|... - gi\|24115529\|ref\|NP_710039.1\| FtsH protease regulator HflK [Shigella flexneri 2a str. 301], gi\|240548... gi\|30043810, gi\|... - gi\|30065546\|ref\|NP_839717.1\| FtsH protease regulator HflK [Shigella flexneri 2a str. 2457T], gi\|3004...	315.0	[0..1]	[419..1]
gi\|16763182 - gi\|16763182\|ref\|NP_458799.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|213428670 - gi\|213428670\|ref\|ZP_03361420.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|213612846 - gi\|213612846\|ref\|ZP_03370672.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|213648971 - gi\|213648971\|ref\|ZP_03379024.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|29140300, gi\|... - gi\|29144661\|ref\|NP_808003.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|214003357 - gi\|214003357\|ref\|ZP_03414092.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|16505490, gi\|... - gi\|25512194\|pir\|\|AC1049 HflK protein [imported] - Salmonella enterica subsp. enterica serovar Typhi ...	314.0	[0..1]	[419..1]
gi\|62182809, gi\|... - gi\|62182809\|ref\|YP_219226.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|194735493, gi... - gi\|194735493\|ref\|YP_002117304.1\| HflK protein [Salmonella enterica subsp. enterica serovar Schwarzen... gi\|197263245, gi... - gi\|197263245\|ref\|ZP_03163319.1\| HflK protein [Salmonella enterica subsp. enterica serovar Saintpaul ... gi\|194448275, gi... - gi\|194448275\|ref\|YP_002048406.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|56130411, gi\|... - gi\|56416154\|ref\|YP_153229.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica serov... gi\|194458469, gi... - gi\|194472105\|ref\|ZP_03078089.1\| HflK protein [Salmonella enterica subsp. enterica serovar Kentucky s... gi\|205348006, gi... - gi\|205348006\|gb\|EDZ34637.1\| HflK protein [Salmonella enterica subsp. enterica serovar Hadar str. RI_... gi\|194442767, gi... - gi\|194442767\|ref\|YP_002043618.1\| HflK protein [Salmonella enterica subsp. enterica serovar Newport s... gi\|197287604, gi... - gi\|197287604\|gb\|EDY26996.1\| HflK protein [Salmonella enterica subsp. enterica serovar Schwarzengrund... gi\|205336314, gi... - gi\|205336314\|gb\|EDZ23078.1\| HflK protein [Salmonella enterica subsp. enterica serovar Heidelberg str... gi\|238910521 - gi\|238910521\|ref\|ZP_04654358.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica se... gi\|205321597, gi... - gi\|205321597\|gb\|EDZ09436.1\| HflK protein [Salmonella enterica subsp. enterica serovar Saintpaul str.... gi\|205334375, gi... - gi\|205334375\|gb\|EDZ21139.1\| HflK protein [Salmonella enterica subsp. enterica serovar Kentucky str. ... lcl\|NC_016856.1_... - [gene=hflK] [protein=FtsH protease regulator HflK] [protein_id=YP_005240675.1] [location=4619281..46... gi\|16422924, gi\|... - gi\|16767609\|ref\|NP_463224.1\| FtsH protease regulator HflK [Salmonella typhimurium LT2], gi\|16422924\|... gi\|207859509, gi... - gi\|207859509\|ref\|YP_002246160.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|224586203, gi... - gi\|224586203\|ref\|YP_002640002.1\| HflK protein [Salmonella enterica subsp. enterica serovar Paratyphi... gi\|204926789, gi... - gi\|204926789\|ref\|ZP_03217991.1\| HflK protein [Salmonella enterica subsp. enterica serovar Javiana st... gi\|205274902, gi... - gi\|205355121\|ref\|YP_002228922.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|197365080, gi... - gi\|197365080\|ref\|YP_002144717.1\| FtsH protease regulator HflK [Salmonella enterica subsp. enterica s... gi\|199604980, gi... - gi\|200387882\|ref\|ZP_03214494.1\| HflK protein [Salmonella enterica subsp. enterica serovar Virchow st...	314.0	[0..1]	[419..1]
gi\|88858906, gi\|... - gi\|88858906\|ref\|ZP_01133547.1\| HflK complex with HflC [Pseudoalteromonas tunicata D2], gi\|88819132\|g...	309.0	[0..1]	[370..3]
gi\|78512040, gi\|... - gi\|78688659\|ref\|ZP_00853327.1\| HflK [Shewanella sp. MR-7], gi\|78512040\|gb\|EAP25394.1\| HflK [Shewanel...	307.0	[0..1]	[418..1]

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Predicted Domain #1

Region A:
Residues: [1-126]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWNQPGNNG QDRDPWGSSK PGGNSEGNGN KGGRDQGPPD LDDIFRKLSK KLGGLGGGKG  60
   61 TGSGGGSSSQ GPRPQLGGRV VTIAAAAIVI IWAASGFYTI KEAERGVVTR FGKFSHLVEP 120
  121 GLNWKP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [127-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFIDEVKPVN VEAVRELAAS GVMLTSDENV VRVEMNVQYR VTNPEKYLYS VTSPDDSLRQ  60
   61 ATDSALRGVI GKYTMDRILT EGRTVIRSDT QRELEETIRP YDMGITLLDV NFQAARPPEE 120
  121 VKAAFDDAIA ARENEQQYIR EAEAYTNEVQ PRANGQAQR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.36
Match:	1winA
Description:	Solution Structure of the Band 7 Domain of the mouse Flotillin 2 Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.45278097493666	bayes_pls_golite062009
protein binding	0.741098311996669	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [286-419]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILEEARAYKA QTILEAQGEV ARFAKLLPEY KAAPEITRER LYIETMEKVL GNTRKVLVND  60
   61 KGGNLMVLPL DQMLKGGNAP AAKSDNGASN LLRLPPASSS TTSGASNTSS TSQGDIMDQR 120
  121 RANAQRNDYQ RQGE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: