YRC Public Data Repository - Protein Structure Prediction

Protein:	HELD_ECOLI
Organism:	Escherichia coli
Length:	684 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HELD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110641152, gi... - gi\|110641152\|ref\|YP_668882.1\| DNA helicase IV [Escherichia coli 536], gi\|110342744\|gb\|ABG68981.1\| he...	461.0	[0..1]	[684..32]
gi\|227838830, gi... - gi\|227884078\|ref\|ZP_04001883.1\| helicase IV [Escherichia coli 83972], gi\|227838830\|gb\|EEJ49296.1\| he... gi\|26246984, gi\|... - gi\|26246984\|ref\|NP_753024.1\| Helicase IV [Escherichia coli CFT073], gi\|26107384\|gb\|AAN79567.1\|AE0167...	460.0	[0..1]	[684..32]
gi\|226898263, gi... - gi\|237707053\|ref\|ZP_04537534.1\| HelD [Escherichia sp. 3_2_53FAA], gi\|226898263\|gb\|EEH84522.1\| HelD [... gi\|117623172, gi... - gi\|117623172\|ref\|YP_852085.1\| DNA helicase IV [Escherichia coli APEC O1], gi\|115512296\|gb\|ABJ00371.1... gi\|91071632, gi\|... - gi\|91210058\|ref\|YP_540044.1\| DNA helicase IV [Escherichia coli UTI89], gi\|91071632\|gb\|ABE06513.1\| DN...	460.0	[0..1]	[684..32]
gi\|110804978, gi... - gi\|110804978\|ref\|YP_688498.1\| DNA helicase IV [Shigella flexneri 5 str. 8401], gi\|110614526\|gb\|ABF03...	455.0	[0..1]	[684..24]
gi\|157077648, gi... - gi\|75190030\|ref\|ZP_00703297.1\| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli E24377... gi\|75255126, gi\|... - gi\|75255126\|ref\|ZP_00727013.1\| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli E22], ... gi\|194411746, gi... - gi\|75208518\|ref\|ZP_00708836.1\| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli B171],...	454.0	[0..1]	[684..1]
gi\|75230237, gi\|... - gi\|75230237\|ref\|ZP_00716734.1\| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli B7A], ...	454.0	[0..1]	[684..1]
gi\|74311519, gi\|... - gi\|74311519\|ref\|YP_309938.1\| DNA helicase IV [Shigella sonnei Ss046], gi\|73854996\|gb\|AAZ87703.1\| DNA... gi\|187428369, gi... - gi\|75175477\|ref\|ZP_00695697.1\| COG0210: Superfamily I DNA and RNA helicases [Shigella boydii BS512],...	453.0	[0..1]	[684..1]
gi\|193070024, gi... - gi\|75235200\|ref\|ZP_00719442.1\| COG0210: Superfamily I DNA and RNA helicases [Escherichia coli E11001... gi\|218553549, gi... - gi\|218553549\|ref\|YP_002386462.1\| DNA helicase IV [Escherichia coli IAI1], gi\|218360317\|emb\|CAQ97867.... gi\|218351169, gi... - gi\|218694437\|ref\|YP_002402104.1\| DNA helicase IV [Escherichia coli 55989], gi\|218351169\|emb\|CAU96873... gi\|209918215, gi... - gi\|209918215\|ref\|YP_002292299.1\| DNA helicase IV [Escherichia coli SE11], gi\|209911474\|dbj\|BAG76548....	453.0	[0..1]	[684..1]
gi\|168751278, gi... - gi\|188014697\|gb\|EDU52819.1\| helicase IV [Escherichia coli O157:H7 str. EC4113], gi\|168751278\|ref\|ZP_... gi\|168758918, gi... - gi\|189354358\|gb\|EDU72777.1\| helicase IV [Escherichia coli O157:H7 str. EC4401], gi\|168758918\|ref\|ZP_... gi\|254792162, gi... - gi\|254792162\|ref\|YP_003076999.1\| DNA helicase IV [Escherichia coli O157:H7 str. TW14359], gi\|2545915... gi\|15830300, gi\|... - gi\|15830300\|ref\|NP_309073.1\| DNA helicase IV [Escherichia coli O157:H7 str. Sakai], gi\|13360506\|dbj\|... gi\|209400242, gi... - gi\|209400242\|ref\|YP_002269630.1\| helicase IV [Escherichia coli O157:H7 str. EC4115], gi\|209161642\|gb... gi\|217320345, gi... - gi\|217324124\|ref\|ZP_03440208.1\| helicase IV [Escherichia coli O157:H7 str. TW14588], gi\|217320345\|gb... gi\|189376521, gi... - gi\|189376521\|gb\|EDU94937.1\| helicase IV [Escherichia coli O157:H7 str. EC508], gi\|168801336\|ref\|ZP_0... gi\|195935149 - gi\|195935149\|ref\|ZP_03080531.1\| DNA helicase IV [Escherichia coli O157:H7 str. EC4024] gi\|15830300, gi\|... - gi\|15830300\|ref\|NP_309073.1\| DNA helicase IV [Escherichia coli O157:H7], gi\|13360506\|dbj\|BAB34469.1\|... gi\|208805656, gi... - gi\|208805656\|ref\|ZP_03247993.1\| helicase IV [Escherichia coli O157:H7 str. EC4206], gi\|208725457\|gb\|... gi\|25290787, gi\|... - pir\|\|D85623 DNA helicase IV [imported] - Escherichia coli (strain O157:H7, substrain EDL933), pir\|\|... gi\|208732294, gi... - gi\|208815646\|ref\|ZP_03256825.1\| helicase IV [Escherichia coli O157:H7 str. EC4045], gi\|208732294\|gb\|... gi\|189364952, gi... - gi\|189364952\|gb\|EDU83368.1\| helicase IV [Escherichia coli O157:H7 str. EC4501], gi\|168765223\|ref\|ZP_... gi\|12514147, gi\|... - gi\|15800821\|ref\|NP_286837.1\| DNA helicase IV [Escherichia coli O157:H7 EDL933], gi\|12514147\|gb\|AAG55... gi\|168777449, gi... - gi\|187767340\|gb\|EDU31184.1\| helicase IV [Escherichia coli O157:H7 str. EC4196], gi\|168777449\|ref\|ZP_... gi\|189001300, gi... - gi\|189001300\|gb\|EDU70286.1\| helicase IV [Escherichia coli O157:H7 str. EC4076], gi\|168780909\|ref\|ZP_... gi\|189372675, gi... - gi\|189372675\|gb\|EDU91091.1\| helicase IV [Escherichia coli O157:H7 str. EC869], gi\|168787395\|ref\|ZP_0...	452.0	[0..1]	[684..1]
gi\|30062501, gi\|... - gi\|30062501\|ref\|NP_836672.1\| DNA helicase IV [Shigella flexneri 2a str. 2457T], gi\|30040747\|gb\|AAP16... gi\|56479783, gi\|... - gi\|56479783\|ref\|NP_706885.2\| DNA helicase IV [Shigella flexneri 2a str. 301], gi\|56383334\|gb\|AAN4259...	452.0	[0..1]	[684..1]

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Predicted Domain #1

Region A:
Residues: [1-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELKATTLGK RLAQHPYDRA VILNAGIKVS GDRHEYLIPF NQLLAIHCKR GLVWGELEFV  60
   61 LPDEKVVRLH GTEWGETQRF YHHLDAHWRR WSGEMSEIAS GVLRQQLDLI ATRTGENKWL 120
  121 TREQTSGVQQ QIRQALSALP LPVNRLEEFD NCREAWRKCQ AWLKDIESAR LQHNQAYTEA 180
  181 MLTEYADFFR Q

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.827	0.250	ATP-dependent DNA helicase activity	a.1.1	Globin-like

Predicted Domain #2

Region A:
Residues: [192-684]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VESSPLNPAQ ARAVVNGEHS LLVLAGAGSG KTSVLVARAG WLLARGEASP EQILLLAFGR  60
   61 KAAEEMDERI RERLHTEDIT ARTFHALALH IIQQGSKKVP IVSKLENDTA ARHELFIAEW 120
  121 RKQCSEKKAQ AKGWRQWLTE EMQWSVPEGN FWDDEKLQRR LASRLDRWVS LMRMHGGAQA 180
  181 EMIASAPEEI RDLFSKRIKL MAPLLKAWKG ALKAENAVDF SGLIHQAIVI LEKGRFISPW 240
  241 KHILVDEFQD ISPQRAALLA ALRKQNSQTT LFAVGDDWQA IYRFSGAQMS LTTAFHENFG 300
  301 EGERCDLDTT YRFNSRIGEV ANRFIQQNPG QLKKPLNSLT NGDKKAVTLL DESQLDALLD 360
  361 KLSGYAKPEE RILILARYHH MRPASLEKAA TRWPKLQIDF MTIHASKGQQ ADYVIIVGLQ 420
  421 EGSDGFPAAA RESIMEEALL PPVEDFPDAE ERRLMYVALT RARHRVWALF NKENPSPFVE 480
  481 ILKNLDVPVA RKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.69897
Match:	2is1A
Description:	No description for 2is1A was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits