YRC Public Data Repository - Protein Structure Prediction

Protein:	HCAE_ECOLI
Organism:	Escherichia coli
Length:	453 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCAE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75515877 - gi\|75515877\|ref\|ZP_00738012.1\| COG4638: Phenylpropionate dioxygenase and related ring-hydroxylating ...	388.0	[0..1]	[453..1]
HCAE_ECOHS - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Escherichia coli O9:H4 (strain HS) GN=...	387.0	[0..1]	[453..1]
HCAE_SHIF8 - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Shigella flexneri serotype 5b (strain ...	387.0	[0..1]	[453..1]
HCAE_SHIBS - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Shigella boydii serotype 4 (strain Sb2...	386.0	[0..1]	[453..1]
gi\|83570759 - gi\|83570759\|ref\|ZP_00922202.1\| COG4638: Phenylpropionate dioxygenase and related ring-hydroxylating ...	386.0	[0..1]	[453..1]
gi\|24052963, gi\|... - gi\|24113867\|ref\|NP_708377.1\| large terminal subunit of phenylpropionate dioxygenase [Shigella flexne... gi\|30063928, gi\|... - gi\|30063928\|ref\|NP_838099.1\| large terminal subunit of phenylpropionate dioxygenase [Shigella flexne... HCAE_SHIFL - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Shigella flexneri GN=hcaE PE=3 SV=1	386.0	[0..1]	[453..1]
HCAE_PHOLL - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Photorhabdus luminescens subsp. laumon... HCAE_PHOLL - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha OS=Photorhabdus luminescens subsp. laumon...	370.0	[0..1]	[453..1]
gi\|75227891 - gi\|75227891\|ref\|ZP_00714599.1\| COG4638: Phenylpropionate dioxygenase and related ring-hydroxylating ...	345.0	[0..1]	[453..1]
gi\|1542960, gi\|3... - gi\|33867210\|ref\|NP_898768.1\| IPB-dioxygenase, ISP large subunit (IpbA1) [Rhodococcus erythropolis], ...	335.0	[0..4]	[446..17]
BPHA1_RHOJR - Biphenyl 2,3-dioxygenase subunit alpha OS=Rhodococcus jostii (strain RHA1) GN=bphA1 PE=1 SV=1 gi\|55670328, gi\|... - gi\|55670328\|pdb\|1ULJ\|E Chain E, Biphenyl Dioxygenase (Bpha1a2) In Complex With The Substrate, gi\|556...	334.0	[0..4]	[446..17]

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Predicted Domain #1

Region A:
Residues: [1-453]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTPSDLNIY QLIDTQNGRV TPRIYTDPDI YQLELERIFG RCWLFLAHES QIPKPGDFFN  60
   61 TYMGEDAVVV VRQKDGSIKA FLNQCRHRAM RVSYADCGNT RAFTCPYHGW SYGINGELID 120
  121 VPLEPRAYPQ GLCKSHWGLN EVPCVESYKG LIFGNWDTSA PGLRDYLGDI AWYLDGMLDR 180
  181 REGGTEIVGG VQKWVINCNW KFPAEQFASD QYHALFSHAS AVQVLGAKDD GSDKRLGDGQ 240
  241 TARPVWETAK DALQFGQDGH GSGFFFTEKP DANVWVDGAV SSYYRETYAE AEQRLGEVRA 300
  301 LRLAGHNNIF PTLSWLNGTA TLRVWHPRGP DQVEVWAFCI TDKAASDEVK AAFENSATRA 360
  361 FGPAGFLEQD DSENWCEIQK LLKGHRARNS KLCLEMGLGQ EKRRDDGIPG ITNYIFSETA 420
  421 ARGMYQRWAD LLSSESWQEV LDKTAAYQQE VMK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.69897
Match:	1uliA
Description:	Biphenyl dioxygenase (BphA1A2) derived from Rhodococcus sp. strain RHA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.3820792276284	bayes_pls_golite062009
oxidoreductase activity	0.194421372741844	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: