YRC Public Data Repository - Protein Structure Prediction

Protein:	HCAD_ECOLI
Organism:	Escherichia coli
Length:	400 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HCAD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|49530718, gi\|... - gi\|50084742\|ref\|YP_046252.1\| putative ferredoxin reductase component (dioxygenase) [Acinetobacter sp...	313.0	[0..1]	[400..1]
gi\|55584976 - gi\|55584976\|gb\|AAV53700.1\| DdmA1 [Stenotrophomonas maltophilia] gi\|55584976 - gb\|AAV53700.1\| DdmA1 [Stenotrophomonas maltophilia]	311.0	[0..1]	[400..1]
gi\|72118581, gi\|... - gi\|73541168\|ref\|YP_295688.1\| FAD-dependent pyridine nucleotide-disulphide oxidoreductase [Ralstonia ...	310.0	[0..1]	[399..2]
gi\|51997118 - gi\|51997118\|emb\|CAH04397.1\| ferredoxin reductase [Mycobacterium sp. HXN-1500]	309.0	[0..6]	[400..10]
gi\|14518332, gi\|... - gi\|14518332\|ref\|NP_116815.1\| putative ferredoxin reductase [Microscilla sp. PRE1], gi\|14484967\|gb\|AA...	309.0	[0..3]	[400..5]
gi\|90416419\|ref\|... - ferredoxin reductase [marine gamma proteobacterium HTCC2207] gi\|90331618, gi\|... - gi\|90416419\|ref\|ZP_01224350.1\| ferredoxin reductase [marine gamma proteobacterium HTCC2207], gi\|9033...	303.0	[0..3]	[400..4]
gi\|84871633, gi\|... - gi\|84871633\|dbj\|BAE75877.1\| ferredoxin reductase component of carbazole 1,9a-dioxygenase [Sphingomon...	300.0	[0..5]	[400..3]
gi\|91700988, gi\|... - gi\|91791107\|ref\|YP_552057.1\| FAD-dependent pyridine nucleotide-disulphide oxidoreductase [Polaromona...	300.0	[0..22]	[400..21]
gi\|25285726 - pir\|\|C87686 ferredoxin reductase [imported] - Caulobacter crescentus gi\|16127755, gi\|... - gi\|16127755\|ref\|NP_422319.1\| ferredoxin reductase [Caulobacter crescentus CB15], gi\|13425257\|gb\|AAK2...	297.0	[0..6]	[399..11]

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Predicted Domain #1

Region A:
Residues: [1-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEKTIIIVG GGQAAAMAAA SLRQQGFTGE LHLFSDERHL PYERPPLSKS MLLEDSPQLQ  60
   61 QVLPANWWQE NNVHLHSGVT IKTLGRDTRE LVLTNGESWH WDQLFIATGA AARPLPLLDA 120
  121 LGERCFTLRH AGDAARLREV LQPERSVVII GAGTIGLELA ASATQRRCKV TVIELAATVM 180
  181 GRNAPPPVQR YLLQRHQQAG VRILLNNAIE HVVDGEKVEL TLQSGETLQA DVVIYGIGIS 240
  241 ANEQLAREAN LDTANGIVID EACRTCDPAI FAGGDVAITR LDNGALHRCE SWENANNQAQ 300
  301 IAAAAMLGLP LPLLPPPWFW SDQYSDNLQF IGDMRGDDWL CRGNPETQKA IWFNLQNGVL 360
  361 IGAVTLNQGR EIRPIRKWIQ SGKTFDAKLL IDENIALKSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1q1rA
Description:	Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors	2.93825791450978	bayes_pls_golite062009
catalytic activity	2.35839632763616	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.26759256126332	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	2.07012504378541	bayes_pls_golite062009
antioxidant activity	1.33376166119593	bayes_pls_golite062009
protein binding	1.21627488765992	bayes_pls_golite062009
oxidoreductase activity	1.08098981906831	bayes_pls_golite062009
binding	1.07739303382566	bayes_pls_golite062009
cation transmembrane transporter activity	1.07537004552946	bayes_pls_golite062009
ion transmembrane transporter activity	1.03749019030988	bayes_pls_golite062009
disulfide oxidoreductase activity	0.905076028978344	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.684108511779641	bayes_pls_golite062009
thioredoxin-disulfide reductase activity	0.461441500451082	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.42812648479755	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.273892309597266	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: