YRC Public Data Repository - Protein Structure Prediction

Protein:	FGF13_RAT
Organism:	Rattus norvegicus
Length:	245 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FGF13_RAT.

Description	E-value	Query Range	Subject Range
gi\|60811740, gi\|... - gi\|60825649\|gb\|AAX36728.1\| fibroblast growth factor 13 [synthetic construct], gi\|60811740\|gb\|AAX3618...	308.0	[0..1]	[245..1]
FGF13_PONPY - Fibroblast growth factor 13 - Pongo pygmaeus (Orangutan) HGNC:3670\|MIM:30... - growth factor 13 FGF13 - fibroblast growth factor 13 FGF13_PONAB - Fibroblast growth factor 13 OS=Pongo abelii GN=FGF13 PE=2 SV=1 gi\|114690338 - gi\|114690338\|ref\|XP_001138460.1\| PREDICTED: fibroblast growth factor 13 isoform 1 [Pan troglodytes] CCDS14665.1_1 - null gi\|61364837, gi\|... - gi\|61364837\|gb\|AAX42611.1\| fibroblast growth factor 13 [synthetic construct], gi\|123998141\|gb\|ABM866... gi\|109132467 - gi\|109132467\|ref\|XP_001084335.1\| PREDICTED: fibroblast growth factor 13 isoform 3 [Macaca mulatta]	307.0	[0..1]	[245..1]
gi\|74008559 - gi\|74008559\|ref\|XP_549294.2\| PREDICTED: similar to fibroblast growth factor 13 isoform 1 [Canis fami...	306.0	[0..1]	[245..1]
FGFD_MOUSE, FGF1... - (P70377) Fibroblast growth factor-13 (FGF-13) (Fibroblast growth factor homologous factor 2) (FHF-2)...	306.0	[0..1]	[245..1]
gi\|6911133, gi\|4... - gi\|6911133\|gb\|AAF31398.1\|AF199611_1 fibroblast growth factor homologous factor 2 isoform 1T+1S' [Gal...	305.0	[0..1]	[245..1]
gi\|76668573 - gi\|76668573\|ref\|XP_878329.1\| PREDICTED: similar to fibroblast growth factor 13 isoform 4 [Bos taurus...	301.0	[0..1]	[245..1]
gi\|56201430 - gi\|56201430\|dbj\|BAD72887.1\| FGF13 [Danio rerio]	300.0	[0..1]	[245..1]

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Predicted Domain #1

Region A:
Residues: [1-61]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR  60
   61 R

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [62-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEPQLKGIVT KLYSRQGYHL QLQADGTIDG TKDEDSTYTL FNLIPVGLRV VAIQGVQTKL  60
   61 YLAMNSEGYL YTSEHFTPEC KFKESVFENY YVTYSSMIYR QQQSGRGWYL GLNKEGEIMK 120
  121 GNHVKKNKPA AHFLPKPLKV AMYKEPSLHD LTEFSRSGSG TPTKSRSVSG VLNGGKSMSH 180
  181 NEST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.522879
Match:	1q1uA
Description:	Crystal structure of human FHF1b (FGF12b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor binding	4.30358117760805	bayes_pls_golite062009
growth factor activity	3.97089267530575	bayes_pls_golite062009
cytokine activity	3.76931834545338	bayes_pls_golite062009
binding	2.90110516688922	bayes_pls_golite062009
protein binding	1.94397222237906	bayes_pls_golite062009
fibroblast growth factor receptor binding	1.9437092554389	bayes_pls_golite062009
pattern binding	0.839280621598109	bayes_pls_golite062009
interleukin-1 receptor binding	0.8084616632765	bayes_pls_golite062009
glycosaminoglycan binding	0.69866345905635	bayes_pls_golite062009
heparin binding	0.290941670257021	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: