YRC Public Data Repository - Protein Structure Prediction

Protein:	GPMA_ECOLI
Organism:	Escherichia coli
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPMA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|60466735, gi\|... - gi\|66809133\|ref\|XP_638289.1\| phosphoglycerate mutase [Dictyostelium discoideum AX4], gi\|60466735\|gb\|... PGAM_DICDI - Probable phosphoglycerate mutase OS=Dictyostelium discoideum GN=gpmA PE=1 SV=1	276.0	[0..2]	[249..2]
GPMA_SOLUE - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Solibacter usitatus (strain Ellin6076) ...	275.0	[0..2]	[249..1]
GPMA_CHLPM - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Chlorobium phaeovibrioides (strain DSM ...	275.0	[0..2]	[248..1]
GPMA_THETN - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Thermoanaerobacter tengcongensis GN=gpm... GPMA_CALS4 - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Caldanaerobacter subterraneus subsp. te...	273.0	[0..2]	[249..1]
GPMA_BDEBA - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Bdellovibrio bacteriovorus (strain ATCC... GPMA_BDEBA - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Bdellovibrio bacteriovorus GN=gpmA PE=3...	271.0	[0..2]	[249..1]
GPMA_PORGI - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Porphyromonas gingivalis (strain ATCC B... GPMA_PORGI - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Porphyromonas gingivalis GN=gpmA PE=3 S... GPMA_PORG3 - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Porphyromonas gingivalis (strain ATCC 3...	270.0	[0..2]	[249..1]
GPMA_CHLPB - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS=Chlorobium phaeobacteroides (strain BS1...	270.0	[0..2]	[248..1]
gi\|67624535 - gi\|67624535\|ref\|XP_668550.1\| phosphoglycerate mutase [Cryptosporidium hominis TU502] gi\|54659749 - gi\|54659749\|gb\|EAL38313.1\| phosphoglycerate mutase [Cryptosporidium hominis]	269.0	[0..2]	[249..2]
gi\|46229585 - gi\|46229585\|gb\|EAK90403.1\| glycolytic phosphoglycerate mutase [Cryptosporidium parvum Iowa II] gi\|66363230 - gi\|66363230\|ref\|XP_628581.1\| glycolytic phosphoglycerate mutase [Cryptosporidium parvum Iowa II]	269.0	[0..2]	[249..2]
gi\|92399533 - gi\|92399533\|gb\|ABE76508.1\| phosphoglycerate mutase 2 [Toxoplasma gondii]	268.0	[0..1]	[248..17]

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Predicted Domain #1

Region A:
Residues: [1-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVTKLVLVRH GESQWNKENR FTGWYDVDLS EKGVSEAKAA GKLLKEEGYS FDFAYTSVLK  60
   61 RAIHTLWNVL DELDQAWLPV EKSWKLNERH YGALQGLNKA ETAEKYGDEQ VKQWRRGFAV 120
  121 TPPELTKDDE RYPGHDPRYA KLSEKELPLT ESLALTIDRV IPYWNETILP RMKSGERVII 180
  181 AAHGNSLRAL VKYLDNMSEE EILELNIPTG VPLVYEFDEN FKPLKRYYLG NADEIAAKAA 240
  241 AVANQGKAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1e58A
Description:	Phosphoglycerate mutase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoglycerate mutase activity	3.38777226675734	bayes_pls_golite062009
phosphofructokinase activity	3.23286891159765	bayes_pls_golite062009
fructose-2,6-bisphosphate 2-phosphatase activity	2.79017097989614	bayes_pls_golite062009
6-phosphofructo-2-kinase activity	2.66778782568695	bayes_pls_golite062009
acid phosphatase activity	2.30852687504184	bayes_pls_golite062009
hydrolase activity	2.03142958239384	bayes_pls_golite062009
carbohydrate kinase activity	1.86382423322759	bayes_pls_golite062009
carbohydrate phosphatase activity	1.56016941506609	bayes_pls_golite062009
binding	1.50412762608586	bayes_pls_golite062009
catalytic activity	1.37714494241232	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.05740895199147	bayes_pls_golite062009
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity	1.02570448989802	bayes_pls_golite062009
phosphatase activity	0.977262057801137	bayes_pls_golite062009
intramolecular transferase activity, phosphotransferases	0.916759493094631	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.780670874345357	bayes_pls_golite062009
isomerase activity	0.275500708652009	bayes_pls_golite062009
protein binding	0.236742803345453	bayes_pls_golite062009
intramolecular transferase activity	0.22072573159348	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.116796724149401	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: