YRC Public Data Repository - Protein Structure Prediction

Protein:	GLPG_ECOLI
Organism:	Escherichia coli
Length:	276 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLPG_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75260288 - gi\|75260288\|ref\|ZP_00731556.1\| COG0705: Uncharacterized membrane protein (homolog of Drosophila rhom... gi\|75237025 - gi\|75237025\|ref\|ZP_00721081.1\| COG0705: Uncharacterized membrane protein (homolog of Drosophila rhom... gi\|75229567 - gi\|75229567\|ref\|ZP_00716110.1\| COG0705: Uncharacterized membrane protein (homolog of Drosophila rhom... GLPG_ECO55 - Rhomboid protease GlpG OS=Escherichia coli (strain 55989 / EAEC) GN=glpG PE=3 SV=1 gi\|75211790 - gi\|75211790\|ref\|ZP_00711854.1\| COG0705: Uncharacterized membrane protein (homolog of Drosophila rhom... GLPG_ECO24 - Rhomboid protease GlpG OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=glpG PE=3 SV=1 GLPG_ECOSE - Rhomboid protease GlpG OS=Escherichia coli (strain SE11) GN=glpG PE=3 SV=1 GLPG_ECO8A - Rhomboid protease GlpG OS=Escherichia coli O8 (strain IAI1) GN=glpG PE=3 SV=1	217.0	[0..1]	[276..1]
GLPG_SHIBS - Rhomboid protease GlpG OS=Shigella boydii serotype 4 (strain Sb227) GN=glpG PE=3 SV=1	217.0	[0..1]	[276..1]
gi\|15833521, gi\|... - gi\|15833521\|ref\|NP_312294.1\| intramembrane serine protease GlpG [Escherichia coli O157:H7 str. Sakai... gi\|208735831, gi... - gi\|208814554\|ref\|ZP_03255883.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC40... gi\|208806161, gi... - gi\|208806161\|ref\|ZP_03248498.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC42... GLPG_ECO5E - Rhomboid protease GlpG OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=glpG PE=3 SV=1 gi\|187775654, gi... - gi\|187775654\|ref\|ZP_02797687.2\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC41... gi\|168797198, gi... - gi\|189379970\|gb\|EDU98386.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC508], ... gi\|189402769, gi... - gi\|189402769\|ref\|ZP_02790782.2\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC44... gi\|188018326, gi... - gi\|188024498\|ref\|ZP_02772117.2\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC41... GLPG_ECO57 - Rhomboid protease GlpG OS=Escherichia coli O157:H7 GN=glpG PE=3 SV=1 gi\|168753180, gi... - gi\|189359206\|gb\|EDU77625.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC4401],... gi\|209756338, gi... - pir\|\|D86008 protein of glp regulon [imported] - Escherichia coli (strain O157:H7, substrain EDL933)... gi\|168785232, gi... - gi\|189374373\|gb\|EDU92789.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC869], ... gi\|15803931, gi\|... - gi\|15803931\|ref\|NP_289967.1\| intramembrane serine protease GlpG [Escherichia coli O157:H7 EDL933], g... gi\|189002278, gi... - gi\|189002278\|gb\|EDU71264.1\| peptidase, S54 (rhomboid) family [Escherichia coli O157:H7 str. EC4076],... GLPG_SHISS - Rhomboid protease GlpG OS=Shigella sonnei (strain Ss046) GN=glpG PE=3 SV=1 GLPG_SHIDS - Rhomboid protease GlpG OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=glpG PE=3 SV=1 gi\|254795341, gi... - gi\|254795341\|ref\|YP_003080178.1\| predicted intramembrane serine protease [Escherichia coli O157:H7 s...	215.0	[0..1]	[276..1]
GLPG_SHIB3 - Rhomboid protease GlpG OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=glpG PE=3 SV=1	215.0	[0..1]	[276..1]
GLPG_SALCH - Rhomboid protease glpG OS=Salmonella choleraesuis GN=glpG PE=3 SV=1 GLPG_SALCH - Rhomboid protease glpG OS=Salmonella choleraesuis GN=glpG PE=3 SV=1 GLPG_SALCH - Rhomboid protease GlpG OS=Salmonella choleraesuis (strain SC-B67) GN=glpG PE=3 SV=1	215.0	[0..1]	[275..1]
gi\|16131298\|ref\|... - GlpG [Escherichia coli K12], GlpG [Escherichia coli K12] gi\|7429008, gi\|1... - pir\|\|BVECGG glpG protein - Escherichia coli (strain K-12), gi\|1293533\|gb\|AAC28166.1\| the translation...	215.0	[0..1]	[276..1]
GLPG_SALNS - Rhomboid protease GlpG OS=Salmonella newport (strain SL254) GN=glpG PE=3 SV=2 GLPG_SALTY - Rhomboid protease glpG OS=Salmonella typhimurium GN=glpG PE=3 SV=1 lcl\|NC_016856.1_... - [gene=glpG] [protein=intramembrane serine protease GlpG] [protein_id=YP_005239730.1] [location=compl... GLPG_SALG2 - Rhomboid protease GlpG OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=glpG PE=3 SV=1 GLPG_SALTY - Rhomboid protease GlpG OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=glpG PE=3 ... GLPG_SALEP - Rhomboid protease GlpG OS=Salmonella enteritidis PT4 (strain P125109) GN=glpG PE=3 SV=1 gi\|197265408, gi... - gi\|197265408\|ref\|ZP_03165482.1\| glp regulon protein [Salmonella enterica subsp. enterica serovar Sai... GLPG_SALTY - Rhomboid protease glpG OS=Salmonella typhimurium GN=glpG PE=3 SV=1 GLPG_SALDC - Rhomboid protease GlpG OS=Salmonella dublin (strain CT_02021853) GN=glpG PE=3 SV=1 GLPG_SALHS - Rhomboid protease GlpG OS=Salmonella heidelberg (strain SL476) GN=glpG PE=3 SV=1	214.0	[0..1]	[275..1]
gi\|29139894, gi\|... - gi\|29144257\|ref\|NP_807599.1\| intramembrane serine protease GlpG [Salmonella enterica subsp. enterica... gi\|16762770 - gi\|16762770\|ref\|NP_458387.1\| intramembrane serine protease GlpG [Salmonella enterica subsp. enterica... GLPG_SALTI - Rhomboid protease GlpG OS=Salmonella typhi GN=glpG PE=3 SV=1 GLPG_SALTI - Rhomboid protease glpG OS=Salmonella typhi GN=glpG PE=3 SV=1	214.0	[0..1]	[275..1]
GLPG_SALPA - Rhomboid protease GlpG OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=glpG PE=3 SV=1 GLPG_SALPA - Rhomboid protease glpG OS=Salmonella paratyphi A GN=glpG PE=3 SV=1 GLPG_SALPK - Rhomboid protease GlpG OS=Salmonella paratyphi A (strain AKU_12601) GN=glpG PE=3 SV=1	213.0	[0..1]	[275..1]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLMITSFANP RVAQAFVDYM ATQGVILTIQ QHNQSDVWLA DESQAERVRA ELARFLENPA  60
   61 DPRYLAASWQ AGHTGSGLHY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.30103
Match:	2gqcA
Description:	No description for 2gqcA was found.

Predicted Domain #2

Region A:
Residues: [81-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRYPFFAALR ERAGPVTWVM MIACVVVFIA MQILGDQEVM LWLAWPFDPT LKFEFWRYFT  60
   61 HALMHFSLMH ILFNLLWWWY LGGAVEKRLG SGKLIVITLI SALLSGYVQQ KFSGPWFGGL 120
  121 SGVVYALMGY VWLRGERDPQ SGIYLQRGLI IFALIWIVAG WFDLFGMSMA NGAHIAGLAV 180
  181 GLAMAFVDSL NARKRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.522879
Match:	2ic8A
Description:	No description for 2ic8A was found.

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.915847726091983	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: