YRC Public Data Repository - Protein Structure Prediction

Protein:	GLK_ECOLI
Organism:	Escherichia coli
Length:	321 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77979147 - gi\|77979147\|ref\|ZP_00834568.1\| COG0837: Glucokinase [Yersinia intermedia ATCC 29909]	240.0	[0..1]	[321..1]
gi\|45437243, gi\|... - gi\|45442379\|ref\|NP_993918.1\| glucokinase [Yersinia pestis biovar Microtus str. 91001], gi\|45437243\|g... gi\|16123158, gi\|... - gi\|218930026\|ref\|YP_002347901.1\| glucokinase [Yersinia pestis CO92], gi\|16123158\|ref\|NP_406471.1\| gl... gi\|166011159, gi... - gi\|166011159\|ref\|ZP_02232057.1\| glucokinase [Yersinia pestis biovar Antiqua str. E1979001], gi\|16598... GLK_YERPS - Glucokinase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=glk PE=3 SV=1 gi\|165926896, gi... - gi\|165926896\|ref\|ZP_02222728.1\| glucokinase [Yersinia pestis biovar Orientalis str. F1991016], gi\|16... GLK_YERPS - Glucokinase OS=Yersinia pseudotuberculosis GN=glk PE=3 SV=1 gi\|167398832, gi... - gi\|167398832\|ref\|ZP_02304356.1\| glucokinase [Yersinia pestis biovar Antiqua str. UG05-0454], gi\|1670... gi\|89105713, gi\|... - gi\|89105713\|ref\|ZP_01178228.1\| COG0837: Glucokinase [Yersinia pestis biovar Orientalis str. IP275], ... gi\|166212463, gi... - gi\|166212463\|ref\|ZP_02238498.1\| glucokinase [Yersinia pestis biovar Antiqua str. B42003004], gi\|1662... GLK_YERPA - Glucokinase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=glk PE=3 SV=1 gi\|167424441, gi... - gi\|167424441\|ref\|ZP_02316194.1\| glucokinase [Yersinia pestis biovar Mediaevalis str. K1973002], gi\|1... GLK_YERPN - Glucokinase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=glk PE=3 SV=1 gi\|166960890, gi... - gi\|167421401\|ref\|ZP_02313154.1\| glucokinase [Yersinia pestis biovar Orientalis str. MG05-1020], gi\|1... GLK_YERPG - Glucokinase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=glk PE=3 SV=1 gi\|229694931, gi... - gi\|229838565\|ref\|ZP_04458724.1\| glucokinase [Yersinia pestis biovar Orientalis str. PEXU2], gi\|22969... GLK_YERP3 - Glucokinase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=glk PE=3 SV=1 gi\|229899131, gi... - gi\|229899131\|ref\|ZP_04514274.1\| glucokinase [Yersinia pestis biovar Orientalis str. India 195], gi\|2... GLK_YERPY - Glucokinase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=glk PE=3 SV=1 gi\|167469926 - gi\|167469926\|ref\|ZP_02334630.1\| glucokinase [Yersinia pestis FV-1] GLK_YERPE - Glucokinase OS=Yersinia pestis GN=glk PE=3 SV=1 GLK_YERPB - Glucokinase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=glk PE=3 SV=1 gi\|149365158, gi... - gi\|149365158\|ref\|ZP_01887193.1\| glucokinase [Yersinia pestis CA88-4125], gi\|149291571\|gb\|EDM41645.1\|... GLK_YERPP - Glucokinase OS=Yersinia pestis (strain Pestoides F) GN=glk PE=3 SV=1	239.0	[0..1]	[321..1]
gi\|21958288, gi\|... - gi\|22125402\|ref\|NP_668825.1\| glucokinase [Yersinia pestis KIM], gi\|21958288\|gb\|AAM85076.1\|AE013753_7...	239.0	[0..1]	[321..2]
gi\|238789993, gi... - gi\|77975605\|ref\|ZP_00831140.1\| COG0837: Glucokinase [Yersinia frederiksenii ATCC 33641], gi\|23878999...	237.0	[0..1]	[321..1]
GLK_SHISS - Glucokinase OS=Shigella sonnei (strain Ss046) GN=glk PE=3 SV=1	236.0	[0..1]	[321..1]
gi\|77956210, gi\|... - gi\|77956210\|ref\|ZP_00820333.1\| COG0837: Glucokinase [Yersinia bercovieri ATCC 43970], gi\|238786338\|r...	235.0	[0..1]	[321..1]
GLK_SHIDS - Glucokinase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=glk PE=3 SV=1	235.0	[0..1]	[321..1]
gi\|77961220 - gi\|77961220\|ref\|ZP_00825063.1\| COG0837: Glucokinase [Yersinia mollaretii ATCC 43969]	234.0	[0..1]	[321..1]
gi\|227835789, gi... - gi\|227887439\|ref\|ZP_04005244.1\| glucokinase [Escherichia coli 83972], gi\|227835789\|gb\|EEJ46255.1\| gl... sp\|B7UG97\|GLK_ECO27 - Glucokinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=glk PE=3 SV=1 gi\|226901282, gi... - gi\|237704916\|ref\|ZP_04535397.1\| glucokinase [Escherichia sp. 3_2_53FAA], gi\|226901282\|gb\|EEH87541.1\|... GLK_ECOK1 - Glucokinase OS=Escherichia coli O1:K1 / APEC GN=glk PE=3 SV=1 GLK_ECOL6 - Glucokinase OS=Escherichia coli O6 GN=glk PE=3 SV=1 GLK_ECO45 - Glucokinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=glk PE=3 SV=1 GLK_ECOL6 - Glucokinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=glk PE=3 SV=1 GLK_ECO27 - Glucokinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=glk PE=3 SV=1 GLK_ECOUT - Glucokinase OS=Escherichia coli (strain UTI89 / UPEC) GN=glk PE=3 SV=1 GLK_ECOL5 - Glucokinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=glk PE=3 SV=1 GLK_ECO81 - Glucokinase OS=Escherichia coli O81 (strain ED1a) GN=glk PE=3 SV=1 gi\|75237954, gi\|... - gi\|75237954\|ref\|ZP_00721961.1\| COG0837: Glucokinase [Escherichia coli F11], gi\|191173778\|ref\|ZP_0303...	234.0	[0..1]	[321..1]
GLK_SHIF8 - Glucokinase OS=Shigella flexneri serotype 5b (strain 8401) GN=glk PE=3 SV=1 gi\|24052821, gi\|... - gi\|24113745\|ref\|NP_708255.1\| glucokinase [Shigella flexneri 2a str. 301], gi\|24052821\|gb\|AAN43962.1\|... gi\|30042047, gi\|... - gi\|30063792\|ref\|NP_837963.1\| glucokinase [Shigella flexneri 2a str. 2457T], gi\|30042047\|gb\|AAP17773.... GLK_SHIFL - Glucokinase OS=Shigella flexneri GN=glk PE=3 SV=1	234.0	[0..1]	[321..1]

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Predicted Domain #1

Region A:
Residues: [1-321]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKYALVGDV GGTNARLALC DIASGEISQA KTYSGLDYPS LEAVIRVYLE EHKVEVKDGC  60
   61 IAIACPITGD WVAMTNHTWA FSIAEMKKNL GFSHLEIIND FTAVSMAIPM LKKEHLIQFG 120
  121 GAEPVEGKPI AVYGAGTGLG VAHLVHVDKR WVSLPGEGGH VDFAPNSEEE AIILEILRAE 180
  181 IGHVSAERVL SGPGLVNLYR AIVKADNRLP ENLKPKDITE RALADSCTDC RRALSLFCVI 240
  241 MGRFGGNLAL NLGTFGGVFI AGGIVPRFLE FFKASGFRAA FEDKGRFKEY VHDIPVYLIV 300
  301 HDNPGLLGSG AHLRQTLGHI L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.69897
Match:	1q18A
Description:	Crystal structure of E.coli glucokinase (Glk)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbohydrate kinase activity	0.7849166795124	bayes_pls_golite062009
catalytic activity	0.666924658593345	bayes_pls_golite062009
hexokinase activity	0.32024736915472	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: