YRC Public Data Repository - Protein Structure Prediction

Protein:	FUMC_ECOLI
Organism:	Escherichia coli
Length:	467 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUMC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|42410098, gi\|... - gi\|42520360\|ref\|NP_966275.1\| fumarate hydratase [Wolbachia endosymbiont of Drosophila melanogaster],...	568.0	[0..3]	[461..4]
gi\|114768945, gi... - gi\|114768945\|ref\|ZP_01446571.1\| Fumarate lyase [alpha proteobacterium HTCC2255], gi\|114549862\|gb\|EAU... gi\|114768945 - gi\|114768945\|ref\|ZP_01446571.1\| Fumarate lyase [alpha proteobacterium HTCC2255]	567.0	[0..1]	[463..1]
gi\|58584761, gi\|... - gi\|58584761\|ref\|YP_198334.1\| fumarate hydratase [Wolbachia endosymbiont strain TRS of Brugia malayi]...	565.0	[0..3]	[461..4]
gi\|91084043 - gi\|91084043\|ref\|XP_967085.1\| PREDICTED: similar to AGAP001884-PA [Tribolium castaneum]	565.0	[0..1]	[463..33]
gi\|50736122, gi\|... - gi\|57530433\|ref\|NP_001006382.1\| fumarate hydratase [Gallus gallus], gi\|53130266\|emb\|CAG31462.1\| hypo...	560.0	[0..1]	[462..41]
gi\|110679538, gi... - gi\|110679538\|ref\|YP_682545.1\| fumarate hydratase [Roseobacter denitrificans OCh 114], gi\|109455654\|g...	560.0	[0..1]	[463..1]
gi\|116122205, gi... - gi\|116329461\|ref\|YP_799181.1\| fumarate hydratase [Leptospira borgpetersenii serovar Hardjo-bovis L55... gi\|116123624, gi... - gi\|116329935\|ref\|YP_799653.1\| fumarate hydratase [Leptospira borgpetersenii serovar Hardjo-bovis JB1...	560.0	[0..3]	[464..2]
FUMC_PHOLL - Fumarate hydratase class II OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105... FUMC_PHOLL - Fumarate hydratase class II OS=Photorhabdus luminescens subsp. laumondii GN=fumC PE=3 SV=1	559.0	[0..1]	[461..1]
gi\|83841641, gi\|... - gi\|83953696\|ref\|ZP_00962417.1\| Fumarate lyase [Sulfitobacter sp. NAS-14.1], gi\|83841641\|gb\|EAP80810....	559.0	[0..1]	[464..1]
gi\|83942477, gi\|... - gi\|83942477\|ref\|ZP_00954938.1\| Fumarate lyase [Sulfitobacter sp. EE-36], gi\|83846570\|gb\|EAP84446.1\| ...	559.0	[0..1]	[464..1]

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Predicted Domain #1

Region A:
Residues: [1-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTVRSEKDS MGAIDVPADK LWGAQTQRSL EHFRISTEKM PTSLIHALAL TKRAAAKVNE  60
   61 DLGLLSEEKA SAIRQAADEV LAGQHDDEFP LAIWQTGSGT QSNMNMNEVL ANRASELLGG 120
  121 VRGMERKVHP NDDVNKSQSS NDVFPTAMHV AALLALRKQL IPQLKTLTQT LNEKSRAFAD 180
  181 IVKIGRTHLQ DATPLTLGQE ISGWVAMLEH NLKHIEYSLP HVAELALGGT AVGTGLNTHP 240
  241 EYARRVADEL AVITCAPFVT APNKFEALAT CDALVQAHGA LKGLAASLMK IANDVRWLAS 300
  301 GPRCGIGEIS IPENEPGSSI MPGKVNPTQC EALTMLCCQV MGNDVAINMG GASGNFELNV 360
  361 FRPMVIHNFL QSVRLLADGM ESFNKHCAVG IEPNRERINQ LLNESLMLVT ALNTHIGYDK 420
  421 AAEIAKKAHK EGLTLKAAAL ALGYLSEAEF DSWVRPEQMV GSMKAGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	156.0
Match:	1kq7A
Description:	Fumarase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fumarate hydratase activity	4.22589182982073	bayes_pls_golite062009
catalytic activity	2.51282259572665	bayes_pls_golite062009
lyase activity	2.31268471569846	bayes_pls_golite062009
carbon-nitrogen lyase activity	2.2046475419807	bayes_pls_golite062009
histidine ammonia-lyase activity	0.948129236753279	bayes_pls_golite062009
amidine-lyase activity	0.901614580251298	bayes_pls_golite062009
binding	0.854855116369286	bayes_pls_golite062009
argininosuccinate lyase activity	0.617974375213548	bayes_pls_golite062009
ammonia-lyase activity	0.491229595527877	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: