YRC Public Data Repository - Protein Structure Prediction

Protein:	FOLC_ECOLI
Organism:	Escherichia coli
Length:	422 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115513629, gi... - gi\|117624505\|ref\|YP_853418.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esch... gi\|215487528, gi... - gi\|215487528\|ref\|YP_002329959.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|218365997, gi... - gi\|218559228\|ref\|YP_002392141.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|218690475, gi... - gi\|218690475\|ref\|YP_002398687.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|218700791, gi... - gi\|218700791\|ref\|YP_002408420.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|91073186, gi\|... - gi\|91211612\|ref\|YP_541598.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esche... gi\|237704794, gi... - gi\|237704794\|ref\|ZP_04535275.1\| bifunctional folylpolyglutamate synthase/dihydrofolate synthase [Esc...	383.0	[0..1]	[422..1]
gi\|26248704, gi\|... - gi\|26248704\|ref\|NP_754744.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esche... gi\|227887375, gi... - gi\|227887375\|ref\|ZP_04005180.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Es...	383.0	[0..1]	[422..1]
gi\|193068240, gi... - gi\|75238098\|ref\|ZP_00722103.1\| COG0285: Folylpolyglutamate synthase [Escherichia coli E110019], gi\|1...	382.0	[0..1]	[422..1]
gi\|77975508 - gi\|77975508\|ref\|ZP_00831043.1\| COG0285: Folylpolyglutamate synthase [Yersinia frederiksenii ATCC 336...	382.0	[0..1]	[415..1]
gi\|195183054 - gi\|195183054\|dbj\|BAG66614.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esche... gi\|192932131, gi... - gi\|75259774\|ref\|ZP_00731076.1\| COG0285: Folylpolyglutamate synthase [Escherichia coli E22], gi\|19306... gi\|194412508, gi... - gi\|75209302\|ref\|ZP_00709542.1\| COG0285: Folylpolyglutamate synthase [Escherichia coli B171], gi\|1944... gi\|110615828, gi... - gi\|110806280\|ref\|YP_689800.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Shig...	381.0	[0..1]	[422..1]
gi\|218361638, gi... - gi\|218554870\|ref\|YP_002387783.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|124526480, gi... - gi\|124526480\|ref\|ZP_01698433.1\| FolC bifunctional protein [Escherichia coli B], gi\|124501951\|gb\|EAY4... gi\|82544796, gi\|... - gi\|82544796\|ref\|YP_408743.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Shige... gi\|169754304, gi... - gi\|170019376\|ref\|YP_001724330.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|209913074, gi... - gi\|209919815\|ref\|YP_002293899.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [E... gi\|190900281, gi... - gi\|75226800\|ref\|ZP_00713730.1\| COG0285: Folylpolyglutamate synthase [Escherichia coli B7A], gi\|19116... gi\|73856309, gi\|... - gi\|74312832\|ref\|YP_311251.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Shige... gi\|187730129, gi... - gi\|75177896\|ref\|ZP_00697958.1\| COG0285: Folylpolyglutamate synthase [Shigella boydii BS512], gi\|1877...	381.0	[0..1]	[422..1]
gi\|254794208, gi... - gi\|254794208\|ref\|YP_003079045.1\| bifunctional folylpolyglutamate synthase [Escherichia coli O157:H7 ... gi\|15832453, gi\|... - gi\|15832453\|ref\|NP_311226.1\| dihydrofolate:folylpolyglutamate synthetase [Escherichia coli O157:H7],... gi\|209764826, gi... - pir\|\|H85872 dihydrofolate folylpolyglutamate synthetase [imported] - Escherichia coli (strain O157:H... gi\|217327399, gi... - gi\|217327399\|ref\|ZP_03443482.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O... gi\|15802862, gi\|... - gi\|15802862\|ref\|NP_288889.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esche... gi\|208806589, gi... - gi\|208806589\|ref\|ZP_03248926.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O... gi\|208813635, gi... - gi\|208813635\|ref\|ZP_03254964.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O... gi\|208741860, gi... - gi\|208821737\|ref\|ZP_03262057.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O... gi\|209398810, gi... - gi\|209398810\|ref\|YP_002271724.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli ... gi\|189002048, gi... - gi\|189002048\|gb\|EDU71034.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|168787227, gi... - gi\|189372902\|gb\|EDU91318.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|189378959, gi... - gi\|189378959\|gb\|EDU97375.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|195935694 - gi\|195935694\|ref\|ZP_03081076.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Es... gi\|168755072, gi... - gi\|189357609\|gb\|EDU76028.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|189368347, gi... - gi\|189368347\|gb\|EDU86763.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|168767946, gi... - gi\|189362861\|gb\|EDU81280.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|187771040, gi... - gi\|187771040\|gb\|EDU34884.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:... gi\|15832453, gi\|... - gi\|15832453\|ref\|NP_311226.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Esche... gi\|168748169, gi... - gi\|188017290\|gb\|EDU55412.1\| tetrahydrofolate synthase/dihydrofolate synthase [Escherichia coli O157:...	380.0	[0..1]	[422..1]
gi\|77957379 - gi\|77957379\|ref\|ZP_00821437.1\| COG0285: Folylpolyglutamate synthase [Yersinia bercovieri ATCC 43970]	380.0	[0..1]	[415..1]
gi\|82777726, gi\|... - gi\|82777726\|ref\|YP_404075.1\| bifunctional folylpolyglutamate synthase/ dihydrofolate synthase [Shige...	380.0	[0..1]	[422..1]
gi\|75187097, gi\|... - gi\|75187097\|ref\|ZP_00700364.1\| COG0285: Folylpolyglutamate synthase [Escherichia coli E24377A], gi\|1...	380.0	[0..1]	[422..1]

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Predicted Domain #1

Region A:
Residues: [1-422]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIKRTPQAA SPLASWLSYL ENLHSKTIDL GLERVSLVAA RLGVLKPAPF VFTVAGTNGK  60
   61 GTTCRTLESI LMAAGYKVGV YSSPHLVRYT ERVRVQGQEL PESAHTASFA EIESARGDIS 120
  121 LTYFEYGTLS ALWLFKQAQL DVVILEVGLG GRLDATNIVD ADVAVVTSIA LDHTDWLGPD 180
  181 RESIGREKAG IFRSEKPAIV GEPEMPSTIA DVAQEKGALL QRRGVEWNYS VTDHDWAFSD 240
  241 AHGTLENLPL PLVPQPNAAT ALAALRASGL EVSENAIRDG IASAILPGRF QIVSESPRVI 300
  301 FDVAHNPHAA EYLTGRMKAL PKNGRVLAVI GMLHDKDIAG TLAWLKSVVD DWYCAPLEGP 360
  361 RGATAEQLLE HLGNGKSFDS VAQAWDAAMA DAKAEDTVLV CGSFHTVAHV MEVIDARRSG 420
  421 GK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	106.0
Match:	1w78A
Description:	E.coli FolC in complex with DHPP and ADP
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits