YRC Public Data Repository - Protein Structure Prediction

Protein:	FIMD_ECOLI
Organism:	Escherichia coli
Length:	878 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FIMD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|195937325 - gi\|195937325\|ref\|ZP_03082707.1\| FimD [Escherichia coli O157:H7 str. EC4024] gi\|168797883, gi... - gi\|189379584\|gb\|EDU98000.1\| outer membrane usher protein fimD [Escherichia coli O157:H7 str. EC508],... gi\|209397655, gi... - gi\|209397655\|ref\|YP_002273842.1\| outer membrane usher protein fimD [Escherichia coli O157:H7 str. EC... gi\|15834530, gi\|... - gi\|15834530\|ref\|NP_313303.1\| FimD [Escherichia coli O157:H7 str. Sakai], gi\|13364754\|dbj\|BAB38699.1\|... gi\|209749330, gi... - pir\|\|D91288 hypothetical protein ECs5276 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15834530, gi\|... - gi\|15834530\|ref\|NP_313303.1\| FimD [Escherichia coli O157:H7], gi\|13364754\|dbj\|BAB38699.1\| export and... gi\|254595719, gi... - gi\|254796319\|ref\|YP_003081156.1\| outer membrane usher protein, type 1 fimbrial synthesis [Escherichi...	1044.0	[0..1]	[878..1]
gi\|26111636, gi\|... - gi\|26251204\|ref\|NP_757244.1\| Outer membrane usher protein fimD precursor [Escherichia coli CFT073], ...	1043.0	[0..1]	[878..1]
gi\|115515749, gi... - gi\|117626625\|ref\|YP_859948.1\| outer membrane usher protein FimD precursor [Escherichia coli APEC O1]... gi\|91213962, gi\|... - gi\|91213962\|ref\|YP_543948.1\| outer membrane usher protein FimD precursor [Escherichia coli UTI89], g...	1042.0	[0..1]	[878..1]
gi\|25298403 - pir\|\|G86129 hypothetical protein fimD [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15804892, gi\|... - gi\|15804892\|ref\|NP_290933.1\| outer membrane protein; export and assembly of type 1 fimbriae, interru...	1042.0	[0..1]	[878..1]
gi\|110346351, gi... - gi\|110644759\|ref\|YP_672489.1\| outer membrane usher protein FimD precursor [Escherichia coli 536], gi... gi\|191170817, gi... - gi\|191170817\|ref\|ZP_03032369.1\| outer membrane usher protein fimD [Escherichia coli F11], gi\|1909090...	1037.0	[0..1]	[878..1]
gi\|52420902 - gi\|52420902\|emb\|CAH55781.1\| export and assembly outer membrane protein of type 1 fimbriae [Escherich...	1036.0	[0..1]	[878..1]
gi\|110807978, gi... - gi\|110807978\|ref\|YP_691498.1\| Outer membrane usher protein fimD precursor [Shigella flexneri 5 str. ...	1030.0	[0..1]	[878..1]
gi\|157069441, gi... - gi\|75198132\|ref\|ZP_00708202.1\| COG3188: P pilus assembly protein, porin PapC [Escherichia coli HS], ...	1022.0	[0..16]	[878..1]
gi\|192930667, gi... - gi\|75258398\|ref\|ZP_00729829.1\| COG3188: P pilus assembly protein, porin PapC [Escherichia coli E22],...	1022.0	[0..16]	[878..1]
gi\|194426542, gi... - gi\|75212121\|ref\|ZP_00712161.1\| COG3188: P pilus assembly protein, porin PapC [Escherichia coli B171]...	1018.0	[0..16]	[878..1]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYLNLRLYQ RNTQCLHIRK HRLAGFFVRL VVACAFAAQA PLSSADLYFN PRFLADDPQA  60
   61 VADLSRFENG QELPPGTYRV DIYLNNGYMA TRDVTFNTGD SEQGIVPCLT RAQLASMGLN 120
  121 TASVAGMNLL ADDACVPLTT MVQDATAHLD VGQQRLNLTI PQAFMSNRAR GYI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.0
Match:	1ze3D
Description:	Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
fimbrial usher porin activity	3.07403393180075	bayes_pls_golite062009
porin activity	1.02120594936422	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [174-878]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPELWDPGIN AGLLNYNFSG NSVQNRIGGN SHYAYLNLQS GLNIGAWRLR DNTTWSYNSS  60
   61 DRSSGSKNKW QHINTWLERD IIPLRSRLTL GDGYTQGDIF DGINFRGAQL ASDDNMLPDS 120
  121 QRGFAPVIHG IARGTAQVTI KQNGYDIYNS TVPPGPFTIN DIYAAGNSGD LQVTIKEADG 180
  181 STQIFTVPYS SVPLLQREGH TRYSITAGEY RSGNAQQEKT RFFQSTLLHG LPAGWTIYGG 240
  241 TQLADRYRAF NFGIGKNMGA LGALSVDMTQ ANSTLPDDSQ HDGQSVRFLY NKSLNESGTN 300
  301 IQLVGYRYST SGYFNFADTT YSRMNGYNIE TQDGVIQVKP KFTDYYNLAY NKRGKLQLTV 360
  361 TQQLGRTSTL YLSGSHQTYW GTSNVDEQFQ AGLNTAFEDI NWTLSYSLTK NAWQKGRDQM 420
  421 LALNVNIPFS HWLRSDSKSQ WRHASASYSM SHDLNGRMTN LAGVYGTLLE DNNLSYSVQT 480
  481 GYAGGGDGNS GSTGYATLNY RGGYGNANIG YSHSDDIKQL YYGVSGGVLA HANGVTLGQP 540
  541 LNDTVVLVKA PGAKDAKVEN QTGVRTDWRG YAVLPYATEY RENRVALDTN TLADNVDLDN 600
  601 AVANVVPTRG AIVRAEFKAR VGIKLLMTLT HNNKPLPFGA MVTSESSQSS GIVADNGQVY 660
  661 LSGMPLAGKV QVKWGEEENA HCVANYQLPP ESQQQLLTQL SAECR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.965
Match:	1qffA
Description:	Ferric hydroxamate uptake receptor FhuA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.273814039678033	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: