YRC Public Data Repository - Protein Structure Prediction

Protein:	ESD
Organism:	Homo sapiens
Length:	282 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESD.

Description	E-value	Query Range	Subject Range
gi\|114649560 - gi\|114649560\|ref\|XP_001150093.1\| PREDICTED: esterase D/formylglutathione hydrolase isoform 2 [Pan tr...	3.0E-64	[1..282]	[35..316]
gi\|61372767, gi\|... - gi\|61372772\|gb\|AAX43909.1\| esterase D/formylglutathione hydrolase [synthetic construct], gi\|61372767...	7.0E-64	[1..282]	[1..282]
gi\|12654663, gi\|... - gi\|30582957\|gb\|AAP35708.1\| esterase 10 [Homo sapiens], gi\|217035508\|pdb\|3FCX\|B Chain B, Crystal Stru... gi\|60655501, gi\|... - gi\|60655501\|gb\|AAX32314.1\| esterase D/formylglutathione hydrolase [synthetic construct], gi\|60655499...	7.0E-64	[1..282]	[1..282]
gi\|73989006, gi\|... - gi\|73989008\|ref\|XP_855986.1\| PREDICTED: similar to esterase D/formylglutathione hydrolase isoform 2 ...	8.0E-64	[1..282]	[1..282]
ESTD_MOUSE - S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1	8.0E-64	[1..282]	[1..282]
ESTD_PIG - S-formylglutathione hydrolase OS=Sus scrofa GN=ESD PE=2 SV=1	2.0E-63	[1..282]	[1..282]
ESTD_RAT - S-formylglutathione hydrolase OS=Rattus norvegicus GN=Esd PE=2 SV=1	3.0E-63	[1..282]	[1..282]

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Predicted Domain #1

Region A:
Residues: [1-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN  60
   61 FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM 120
  121 YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL 180
  181 CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI 240
  241 AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.045757
Match:	1pv1A
Description:	Crystal Structure Analysis of Yeast Hypothetical Protein: YJG8_YEAST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-formylglutathione hydrolase activity	2.11404818814754	bayes_pls_golite062009
hydrolase activity	1.75934962198703	bayes_pls_golite062009
catalytic activity	1.39629727416851	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.09488027320166	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: