YRC Public Data Repository - Protein Structure Prediction

Protein:	ENVZ_SALTI
Organism:	Salmonella typhi
Length:	450 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ENVZ_SALTI.

Description	E-value	Query Range	Subject Range
gi\|541207 - gi\|541207\|pir\|\|S41888 envZ protein - Salmonella typhi	5.0E-67	[1..450]	[1..450]
gi\|79091, gi\|47665 - pir\|\|S01367 inner membrane protein envZ - Salmonella typhimurium, gi\|47665\|emb\|CAA30935.1\| unnamed p... gi\|47665\|emb\|CAA... - unnamed protein product [Salmonella typhimurium]	1.0E-66	[1..450]	[1..450]
gi\|56415416, gi\|... - gi\|56415416\|ref\|YP_152491.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ... gi\|161365905, gi... - gi\|161616541\|ref\|YP_001590506.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica sero... ENVZ_SALTY - Osmolarity sensor protein envZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2 ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=en... lcl\|NC_016856.1_... - [gene=envZ] [protein=osmolarity sensor protein] [protein_id=YP_005239702.1] [location=complement(367... ENVZ_SALTY - Osmolarity sensor protein EnvZ OS=Salmonella typhimurium GN=envZ PE=3 SV=2	1.0E-66	[1..450]	[1..450]
gi\|45440000, gi\|... - gi\|45440000\|ref\|NP_991539.1\| osmolarity sensor protein [Yersinia pestis biovar Microtus str. 91001],...	5.0E-66	[1..450]	[1..450]
gi\|25298449 - pir\|\|AF0017 osmolarity sensor protein (EC 2.7.3.-) [imported] - Yersinia pestis (strain CO92) gi\|51598053, gi\|... - gi\|51598053\|ref\|YP_072244.1\| osmolarity sensor protein [Yersinia pseudotuberculosis IP 32953], gi\|51... gi\|22127787, gi\|... - gi\|22127787\|ref\|NP_671210.1\| osmolarity sensor protein [Yersinia pestis KIM], gi\|21960916\|gb\|AAM8746... Q664K6\|Q664K6_YERPS - Osmolarity sensor protein precursor - Yersinia pseudotuberculosis gi\|218927348, gi... - gi\|218927348\|ref\|YP_002345223.1\| osmolarity sensor protein [Yersinia pestis CO92], gi\|16120480\|ref\|N... gi\|166010415, gi... - gi\|166010415\|ref\|ZP_02231313.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229706450, gi... - gi\|229836382\|ref\|ZP_04456549.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|165928059, gi... - gi\|165928059\|ref\|ZP_02223891.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|229696359, gi... - gi\|229839993\|ref\|ZP_04460152.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|167051326, gi... - gi\|167398822\|ref\|ZP_02304346.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|229690384, gi... - gi\|229842074\|ref\|ZP_04462229.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|77633467, gi\|... - gi\|77633467\|ref\|ZP_00795597.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis Angola... gi\|166213218, gi... - gi\|166213218\|ref\|ZP_02239253.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Antiqua str. ... gi\|167425631, gi... - gi\|167425631\|ref\|ZP_02317384.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Mediaevalis s... gi\|166963036, gi... - gi\|167419042\|ref\|ZP_02310795.1\| osmolarity sensor protein EnvZ [Yersinia pestis biovar Orientalis st... gi\|186700279, gi... - gi\|186897253\|ref\|YP_001874365.1\| osmolarity sensor protein [Yersinia pseudotuberculosis PB1/+], gi\|1... gi\|170022434, gi... - gi\|170022434\|ref\|YP_001718939.1\| osmolarity sensor protein [Yersinia pseudotuberculosis YPIII], gi\|1... gi\|165936352, gi... - gi\|89105813\|ref\|ZP_01178326.1\| COG0642: Signal transduction histidine kinase [Yersinia pestis biovar... gi\|108809323, gi... - gi\|108809323\|ref\|YP_653239.1\| osmolarity sensor protein [Yersinia pestis Antiqua], gi\|108781236\|gb\|A... gi\|108777736, gi... - gi\|229904625\|ref\|ZP_04519736.1\| sensory histidine kinase in two-component regulatory system with Omp... gi\|149290227, gi... - gi\|150260819\|ref\|ZP_01917547.1\| osmolarity sensor protein [Yersinia pestis CA88-4125], gi\|149290227\|... gi\|145209083, gi... - gi\|145597387\|ref\|YP_001161462.1\| osmolarity sensor protein [Yersinia pestis Pestoides F], gi\|1452090...	7.0E-66	[1..450]	[1..450]
gi\|218429245, gi... - gi\|218691681\|ref\|YP_002399893.1\| osmolarity sensor protein [Escherichia coli ED1a], gi\|218429245\|emb... gi\|190908126, gi... - gi\|75241505\|ref\|ZP_00725350.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110643637, gi... - gi\|110643637\|ref\|YP_671367.1\| osmolarity sensor protein [Escherichia coli 536], gi\|110345229\|gb\|ABG7...	7.0E-66	[1..449]	[1..449]
gi\|110616784, gi... - gi\|110807236\|ref\|YP_690756.1\| osmolarity sensor protein [Shigella flexneri 5 str. 8401], gi\|11061678... gi\|188489393, gi... - gi\|75516128\|ref\|ZP_00738246.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638... gi\|193061701, gi... - gi\|75260307\|ref\|ZP_00731575.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|192957817, gi... - gi\|75237005\|ref\|ZP_00721061.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E1100... gi\|191167875, gi... - gi\|75228941\|ref\|ZP_00715533.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|89110606, gi\|... - gi\|89110606\|ref\|AP_004386.1\| sensory histidine kinase in two-component regulatory system with OmpR [... gi\|82545759, gi\|... - gi\|82545759\|ref\|YP_409706.1\| osmolarity sensor protein [Shigella boydii Sb227], gi\|81247170\|gb\|ABB67... gi\|81242927, gi\|... - gi\|82778779\|ref\|YP_405128.1\| osmolarity sensor protein [Shigella dysenteriae Sd197], gi\|81242927\|gb\|... gi\|73857384, gi\|... - gi\|74313907\|ref\|YP_312326.1\| osmolarity sensor protein [Shigella sonnei Ss046], gi\|73857384\|gb\|AAZ90... gi\|83571675 - gi\|83571675\|ref\|ZP_00923115.1\| COG0642: Signal transduction histidine kinase [Shigella dysenteriae 1... gi\|194414975, gi... - gi\|75211770\|ref\|ZP_00711834.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|75197335, gi\|... - gi\|75197335\|ref\|ZP_00707405.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|157077859, gi... - gi\|75188178\|ref\|ZP_00701445.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437... EG10269 - sensory histidine kinase in two-component regulatory system with OmpR / Osmosensor histidine protein... ENVZ_ECOLI - Osmolarity sensor protein envZ (EC 2.7.13.3) - Escherichia coli gi\|194425497, gi... - gi\|83588731\|ref\|ZP_00927355.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 101-1... gi\|170082921, gi... - gi\|170082921\|ref\|YP_001732241.1\| sensory histidine kinase in two-component regulatory system with Om... gi\|170018360, gi... - gi\|170018360\|ref\|YP_001723314.1\| osmolarity sensor protein [Escherichia coli ATCC 8739], gi\|16975328... gi\|209920860, gi... - gi\|209920860\|ref\|YP_002294944.1\| osmolarity sensor protein [Escherichia coli SE11], gi\|209914119\|dbj... gi\|124528177, gi... - gi\|124528177\|ref\|ZP_01699510.1\| integral membrane sensor signal transduction histidine kinase [Esche... gi\|238902495, gi... - gi\|238902495\|ref\|YP_002928291.1\| sensory histidine kinase in two-component regulatory system with Om... gi\|253771767, gi... - gi\|253771767\|ref\|YP_003034598.1\| histidine kinase [Escherichia coli BL21(DE3)], gi\|253322811\|gb\|ACT2... gi\|226839077, gi... - gi\|254038571\|ref\|ZP_04872627.1\| osmolarity sensor protein EnvZ [Escherichia sp. 1_1_43], gi\|22683907... ENVZ_SHIFL - Osmolarity sensor protein EnvZ OS=Shigella flexneri GN=envZ PE=1 SV=1 gi\|24053874, gi\|... - gi\|24114667\|ref\|NP_709177.1\| osmolarity sensor protein [Shigella flexneri 2a str. 301], gi\|24053874\|... gi\|30043575, gi\|... - gi\|30065313\|ref\|NP_839484.1\| osmolarity sensor protein [Shigella flexneri 2a str. 2457T], gi\|3004357... EG10269 - sensory histidine kinase in two-component regulatory system with OmpR / Osmosensor histidine protein...	1.0E-65	[1..449]	[1..449]
gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. Sakai], gi\|133... gi\|15833500, gi\|... - gi\|15833500\|ref\|NP_312273.1\| osmolarity sensor protein [Escherichia coli O157:H7], gi\|13363720\|dbj\|B... gi\|208739839, gi... - gi\|208819716\|ref\|ZP_03260036.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4042... gi\|25298452, gi\|... - pir\|\|E86005 protein histidine kinase/phosphatase EnvZ [imported] - Escherichia coli (strain O157:H7,... gi\|208734794, gi... - gi\|208813517\|ref\|ZP_03254846.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4045... gi\|217321412, gi... - gi\|217325191\|ref\|ZP_03441275.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. TW1458... gi\|12518031, gi\|... - gi\|15803908\|ref\|NP_289944.1\| osmolarity sensor protein [Escherichia coli O157:H7 EDL933], gi\|1251803... gi\|209158826, gi... - gi\|209397426\|ref\|YP_002272839.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC411... gi\|168797174, gi... - gi\|189379930\|gb\|EDU98346.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC508], gi... gi\|189374410, gi... - gi\|189374410\|gb\|EDU92826.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC869], gi... gi\|208807616, gi... - gi\|208807616\|ref\|ZP_03249953.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4206... gi\|195934893 - gi\|195934893\|ref\|ZP_03080275.1\| osmolarity sensor protein [Escherichia coli O157:H7 str. EC4024] gi\|189364652, gi... - gi\|189364652\|gb\|EDU83071.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4486], g... gi\|189369894, gi... - gi\|189369894\|gb\|EDU88310.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4501], g... gi\|189002223, gi... - gi\|189002223\|gb\|EDU71209.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4076], g... gi\|168772705, gi... - gi\|187771797\|gb\|EDU35641.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4196], g... gi\|189359046, gi... - gi\|189359046\|gb\|EDU77465.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4401], g... gi\|168747119, gi... - gi\|188018349\|gb\|EDU56471.1\| osmolarity sensor protein EnvZ [Escherichia coli O157:H7 str. EC4113], g... gi\|254594719, gi... - gi\|254795319\|ref\|YP_003080156.1\| sensory histidine kinase in two-component regulatory system with Om...	1.0E-65	[1..449]	[1..449]
gi\|26110433, gi\|... - gi\|26250004\|ref\|NP_756044.1\| osmolarity sensor protein [Escherichia coli CFT073], gi\|26110433\|gb\|AAN... gi\|91212878, gi\|... - gi\|91212878\|ref\|YP_542864.1\| osmolarity sensor protein [Escherichia coli UTI89], gi\|91074452\|gb\|ABE0... gi\|115514795, gi... - gi\|117625671\|ref\|YP_858994.1\| osmolarity sensor protein [Escherichia coli APEC O1], gi\|115514795\|gb\|... gi\|218367231, gi... - gi\|218560462\|ref\|YP_002393375.1\| osmolarity sensor protein [Escherichia coli S88], gi\|218367231\|emb\|... gi\|226902398, gi... - gi\|237703134\|ref\|ZP_04533615.1\| osmolarity sensor protein envZ [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|170518903, gi... - gi\|170681185\|ref\|YP_001745652.1\| osmolarity sensor protein EnvZ [Escherichia coli SMS-3-5], gi\|17051... gi\|215266757, gi... - gi\|215488685\|ref\|YP_002331116.1\| osmolarity sensor protein [Escherichia coli O127:H6 str. E2348/69],... gi\|227883538, gi... - gi\|227883538\|ref\|ZP_04001343.1\| sensory histidine kinase in two-component regulatory system with Omp...	1.0E-65	[1..449]	[1..449]
gi\|62182003, gi\|... - gi\|62182003\|ref\|YP_218420.1\| osmolarity sensor protein [Salmonella enterica subsp. enterica serovar ...	1.0E-65	[1..450]	[1..450]

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Predicted Domain #1

Region A:
Residues: [1-127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRMRFSPRS SFARTLLLIV TLLFVSLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD  60
   61 KLQLEDGTQL VVPPAFRREI YRELGISLYT NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT 120
  121 EVRVEVN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.802	d.68.3	SirA-like

Predicted Domain #2

Region A:
Residues: [128-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSSPVVWLKT WLSPNIWVRV PLTEIHQGDF SPLFRYTLAI MLLAIGGAWL FIRIQNRPLV  60
   61 DLEHAALQVG KGIIPPPLRE YGASEVRSVT RAFNHMAAGV KQLADDRTLL MAGVSHDLRT 120
  121 PLTRIRLATE MMGEEDGYLA ESINKDIEEC NAIIEQFIDY LRTGQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.3
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [293-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMPMEMADLN SVLGEVIAAE SGYEREINTA LQAGSIQVKM HPLSIKRAVA NMVVNAARYG  60
   61 NCWIKVSSGT ESHRAWFQVE DDGPGIKPEQ RKHLFQPFVR GDSARSTSGT GLGLAIVQRI 120
  121 IDNHNGMLEI GTSERGGLSI RAWLPVPVAR VQGTTKEA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.39794
Match:	1bxdA
Description:	Histidine kinase domain of the osmosensor EnvZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	4.82398483954378	bayes_pls_golite062009
two-component sensor activity	4.79766298875975	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	4.76164614213074	bayes_pls_golite062009
two-component response regulator activity	3.47298917518553	bayes_pls_golite062009
signal transducer activity	2.91676094682887	bayes_pls_golite062009
molecular transducer activity	2.91676094682887	bayes_pls_golite062009
protein kinase activity	2.34507002285329	bayes_pls_golite062009
kinase activity	2.18775056477858	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.17409873880782	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.98933866931605	bayes_pls_golite062009
transferase activity	1.07472897478108	bayes_pls_golite062009
catalytic activity	0.812403102604677	bayes_pls_golite062009
binding	0.162154598845105	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: