YRC Public Data Repository - Protein Structure Prediction

Protein:	DSBD_ECOLI
Organism:	Escherichia coli
Length:	565 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSBD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115515610, gi... - gi\|117626486\|ref\|YP_859809.1\| thiol:disulfide interchange protein precursor [Escherichia coli APEC O...	467.0	[0..1]	[565..28]
gi\|218561296, gi... - gi\|218561296\|ref\|YP_002394209.1\| thiol:disulfide interchange protein precursor [Escherichia coli S88... DSBD_ECOL5 - Thiol:disulfide interchange protein DsbD OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=dsbD ... DSBD_ECOUT - Thiol:disulfide interchange protein DsbD OS=Escherichia coli (strain UTI89 / UPEC) GN=dsbD PE=3 SV=1 gi\|218430038, gi... - gi\|218692474\|ref\|YP_002400686.1\| thiol:disulfide interchange protein precursor [Escherichia coli ED1... gi\|237703803, gi... - gi\|237703803\|ref\|ZP_04534284.1\| thiol:disulfide interchange protein [Escherichia sp. 3_2_53FAA], gi\|... gi\|191173342, gi... - gi\|75239105\|ref\|ZP_00723085.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli F11], ...	463.0	[0..1]	[565..1]
gi\|251787389, gi... - gi\|251787389\|ref\|YP_003001693.1\| hypothetical protein B21_03968 [Escherichia coli BL21], gi\|24237966... gi\|254164068, gi... - gi\|254164068\|ref\|YP_003047176.1\| thiol:disulfide interchange protein precursor [Escherichia coli B s... gi\|194437198, gi... - gi\|83587259\|ref\|ZP_00925888.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli 101-1]... gi\|254290818, gi... - gi\|254290818\|ref\|YP_003056566.1\| thiol:disulfide interchange protein precursor [Escherichia coli BL2...	462.0	[0..1]	[565..1]
gi\|227836164, gi... - gi\|227886822\|ref\|ZP_04004627.1\| thiol:disulfide interchange protein precursor [Escherichia coli 8397... DSBD_ECOL6 - Thiol:disulfide interchange protein DsbD OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UP... DSBD_ECOL6 - Thiol:disulfide interchange protein DsbD OS=Escherichia coli O6 GN=dsbD PE=3 SV=1	462.0	[0..1]	[565..1]
DSBD_SHIF8 - Thiol:disulfide interchange protein DsbD OS=Shigella flexneri serotype 5b (strain 8401) GN=dsbD PE=3... gi\|218556689, gi... - gi\|218556689\|ref\|YP_002389603.1\| thiol:disulfide interchange protein precursor [Escherichia coli IAI...	461.0	[0..1]	[565..1]
gi\|194428954, gi... - gi\|75209837\|ref\|ZP_00710035.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli B171],... gi\|157163601, gi... - gi\|75197986\|ref\|ZP_00708056.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli HS], g... gi\|157157307, gi... - gi\|75188851\|ref\|ZP_00702118.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli E24377... gi\|195183323 - gi\|195183323\|dbj\|BAG66862.1\| fused thiol:disulfide interchange protein: activator of DsbC/conserved ... gi\|218697886, gi... - gi\|218697886\|ref\|YP_002405553.1\| thiol:disulfide interchange protein precursor [Escherichia coli 559... gi\|192926621, gi... - gi\|75256193\|ref\|ZP_00727881.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli E22], ... gi\|75231268, gi\|... - gi\|75231268\|ref\|ZP_00717675.1\| COG4232: Thiol:disulfide interchange protein [Escherichia coli B7A], ...	461.0	[0..1]	[565..1]
DSBD_SHIDS - Thiol:disulfide interchange protein DsbD OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=dsbD P...	461.0	[0..1]	[565..1]
gi\|187730556, gi... - gi\|75179489\|ref\|ZP_00699493.1\| COG4232: Thiol:disulfide interchange protein [Shigella boydii BS512],...	460.0	[0..1]	[565..1]
gi\|24115491, gi\|... - gi\|24115491\|ref\|NP_710001.1\| thiol:disulfide interchange protein precursor [Shigella flexneri 2a str...	460.0	[0..1]	[565..1]
gi\|209750560, gi... - pir\|\|C86109 thiol disulfide interchange protein [imported] - Escherichia coli (strain O157:H7, subst... DSBD_ECO57 - Thiol:disulfide interchange protein DsbD OS=Escherichia coli O157:H7 GN=dsbD PE=1 SV=1 gi\|15804728, gi\|... - gi\|15804728\|ref\|NP_290769.1\| thiol:disulfide interchange protein precursor [Escherichia coli O157:H7... gi\|217320410, gi... - gi\|217324189\|ref\|ZP_03440273.1\| thiol:disulfide interchange protein DsbD [Escherichia coli O157:H7 s... gi\|15834371, gi\|... - gi\|15834371\|ref\|NP_313144.1\| thiol:disulfide interchange protein precursor [Escherichia coli O157:H7... gi\|168761001, gi... - gi\|189368526\|gb\|EDU86942.1\| thiol:disulfide interchange protein DsbD [Escherichia coli O157:H7 str. ...	460.0	[0..1]	[565..1]

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Predicted Domain #1

Region A:
Residues: [1-161]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQRIFTLIL LLCSTSVFAG LFDAPGRSQF VPADQAFAFD FQQNQHDLNL TWQIKDGYYL  60
   61 YRKQIRITPE HAKIADVQLP QGVWHEDEFY GKSEIYRDRL TLPVTINQAS AGATLTVTYQ 120
  121 GCADAGFCYP PETKTVPLSE VVANNAAPQP VSVPQQEQPT A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.221849
Match:	1jpeA
Description:	Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein disulfide isomerase activity	2.18896015535195	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	2.18896015535195	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	2.02338373977612	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009
isomerase activity	0.121577597676249	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [162-399]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLPFSALWAL LIGIGIAFTP CVLPMYPLIS GIVLGGKQRL STARALLLTF IYVQGMALTY  60
   61 TALGLVVAAA GLQFQAALQH PYVLIGLAIV FTLLAMSMFG LFTLQLPSSL QTRLTLMSNR 120
  121 QQGGSPGGVF VMGAIAGLIC SPCTTAPLSA ILLYIAQSGN MWLGGGTLYL YALGMGLPLM 180
  181 LITVFGNRLL PKSGPWMEQV KTAFGFVILA LPVFLLERVI GDVWGLRLWS ALGVAFFG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [400-565]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WAFITSLQAK RGWMRIVQII LLAAALVSVR PLQDWAFGAT HTAQTQTHLN FTQIKTVDEL  60
   61 NQALVEAKGK PVMLDLYADW CVACKEFEKY TFSDPQVQKA LADTVLLQAN VTANDAQDVA 120
  121 LLKHLNVLGL PTILFFDGQG QEHPQARVTG FMDAETFSAH LRDRQP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.522879
Match:	2fweA
Description:	No description for 2fweA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: