YRC Public Data Repository - Protein Structure Prediction

Protein:	DSBA_SHIFL
Organism:	Shigella flexneri
Length:	208 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSBA_SHIFL.

Description	E-value	Query Range	Subject Range
gi\|168775590, gi... - gi\|187768889\|gb\|EDU32733.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|168768140, gi... - gi\|189362598\|gb\|EDU81017.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|189375314, gi... - gi\|189375314\|gb\|EDU93730.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|168780758, gi... - gi\|189001471\|gb\|EDU70457.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|169891168, gi... - gi\|170083333\|ref\|YP_001732653.1\| periplasmic protein disulfide isomerase I [Escherichia coli str. K-... gi\|170022125, gi... - gi\|170022125\|ref\|YP_001727079.1\| periplasmic protein disulfide isomerase I [Escherichia coli ATCC 87... gi\|208807131, gi... - gi\|208807131\|ref\|ZP_03249468.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 s... gi\|195940267 - gi\|195940267\|ref\|ZP_03085649.1\| periplasmic protein disulfide isomerase I [Escherichia coli O157:H7 ... EG11297 - periplasmic protein disulfide isomerase I / Thiol:disulfide interchange protein, periplasmic; alkali... gi\|124501226, gi... - gi\|124527524\|ref\|ZP_01698989.1\| DSBA oxidoreductase [Escherichia coli B], gi\|124501226\|gb\|EAY48691.1... gi\|168750329, gi... - gi\|188015424\|gb\|EDU53546.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|189364979, gi... - gi\|189364979\|gb\|EDU83395.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... gi\|168755523, gi... - gi\|189357226\|gb\|EDU75645.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 str. ... DSBA_ECO57 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O157:H7 GN=dsbA PE=3 SV=1 gi\|188491865, gi... - gi\|75513990\|ref\|ZP_00736343.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... EG11297 - periplasmic protein disulfide isomerase I / Thiol:disulfide interchange protein, periplasmic; alkali... gi\|73857843, gi\|... - gi\|74314366\|ref\|YP_312785.1\| periplasmic protein disulfide isomerase I [Shigella sonnei Ss046], gi\|7... gi\|218707486, gi... - gi\|218707486\|ref\|YP_002415005.1\| periplasmic protein disulfide isomerase I [Escherichia coli UMN026]... gi\|15804445, gi\|... - gi\|15804445\|ref\|NP_290485.1\| periplasmic protein disulfide isomerase I [Escherichia coli O157:H7 EDL... gi\|75238303, gi\|... - gi\|75238303\|ref\|ZP_00722302.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|192925589, gi... - gi\|75255031\|ref\|ZP_00726943.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... DSBA_ECOLI - Thiol:disulfide interchange protein dsbA precursor - Escherichia coli gi\|81247616, gi\|... - gi\|82546205\|ref\|YP_410152.1\| periplasmic protein disulfide isomerase I [Shigella boydii Sb227], gi\|8... gi\|89110167, gi\|... - gi\|89110167\|ref\|AP_003947.1\| periplasmic protein disulfide isomerase I [Escherichia coli str. K-12 s... gi\|194420904, gi... - gi\|83584515\|ref\|ZP_00923192.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|208821648, gi... - gi\|208821648\|ref\|ZP_03261968.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 s... gi\|187428800, gi... - gi\|75176754\|ref\|ZP_00696882.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Shigella boydii ... gi\|208735795, gi... - gi\|208814518\|ref\|ZP_03255847.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 s... gi\|13364259, gi\|... - gi\|15834037\|ref\|NP_312810.1\| periplasmic protein disulfide isomerase I [Escherichia coli O157:H7 str... gi\|209914591, gi... - gi\|209921332\|ref\|YP_002295416.1\| periplasmic protein disulfide isomerase I [Escherichia coli SE11], ... gi\|110617003, gi... - gi\|110807455\|ref\|YP_690975.1\| periplasmic protein disulfide isomerase I [Shigella flexneri 5 str. 84... gi\|209400816, gi... - gi\|209400816\|ref\|YP_002273372.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 ... gi\|194411509, gi... - gi\|75208258\|ref\|ZP_00708618.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|218363188, gi... - gi\|218556419\|ref\|YP_002389333.1\| periplasmic protein disulfide isomerase I [Escherichia coli IAI1], ... gi\|190900508, gi... - gi\|75227234\|ref\|ZP_00714032.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|217321352, gi... - gi\|217325131\|ref\|ZP_03441215.1\| thiol:disulfide interchange protein DsbA [Escherichia coli O157:H7 s... gi\|157155214, gi... - gi\|75188595\|ref\|ZP_00701862.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|218701440, gi... - gi\|218701440\|ref\|YP_002409069.1\| periplasmic protein disulfide isomerase I [Escherichia coli IAI39],... gi\|157163329, gi... - gi\|75197736\|ref\|ZP_00707806.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli... gi\|218697574, gi... - gi\|218697574\|ref\|YP_002405241.1\| periplasmic protein disulfide isomerase I [Escherichia coli 55989],... gi\|238902928, gi... - gi\|238902928\|ref\|YP_002928724.1\| periplasmic protein disulfide isomerase I [Escherichia coli BW2952]... gi\|251787125, gi... - gi\|251787125\|ref\|YP_003001429.1\| hypothetical protein B21_03695 [Escherichia coli BL21], gi\|24237939... gi\|254163812, gi... - gi\|254163812\|ref\|YP_003046920.1\| periplasmic protein disulfide isomerase I [Escherichia coli B str. ... gi\|254290562, gi... - gi\|254290562\|ref\|YP_003056310.1\| periplasmic protein disulfide isomerase I [Escherichia coli BL21(DE... gi\|254595251, gi... - gi\|254795851\|ref\|YP_003080688.1\| periplasmic protein disulfide isomerase I [Escherichia coli O157:H7...	194.0	[0..1]	[208..1]
DSBA_ECOL6 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O6 GN=dsbA PE=3 SV=1 DSBA_ECOL6 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UP... gi\|115515258, gi... - gi\|117626134\|ref\|YP_859457.1\| periplasmic protein disulfide isomerase I [Escherichia coli APEC O1], ... gi\|218692147, gi... - gi\|218692147\|ref\|YP_002400359.1\| periplasmic protein disulfide isomerase I [Escherichia coli ED1a], ... gi\|91074978, gi\|... - gi\|91213404\|ref\|YP_543390.1\| periplasmic protein disulfide isomerase I [Escherichia coli UTI89], gi\|... gi\|218367705, gi... - gi\|218560936\|ref\|YP_002393849.1\| periplasmic protein disulfide isomerase I [Escherichia coli S88], g... DSBA_ECO27 - Thiol:disulfide interchange protein DsbA OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=dsb... gi\|227885407, gi... - gi\|227885407\|ref\|ZP_04003212.1\| periplasmic protein disulfide isomerase I [Escherichia coli 83972], ... gi\|1040723 - gi\|1040723\|emb\|CAA90910.1\| DsbA protein [Escherichia coli] DSBA_ECO27 - Thiol:disulfide interchange protein dsbA OS=Escherichia coli O127:H6 GN=dsbA PE=3 SV=1 gi\|237702888, gi... - gi\|237702888\|ref\|ZP_04533369.1\| periplasmic protein disulfide isomerase I [Escherichia sp. 3_2_53FAA...	193.0	[0..1]	[208..1]
gi\|81243115, gi\|... - gi\|82778967\|ref\|YP_405316.1\| periplasmic protein disulfide isomerase I [Shigella dysenteriae Sd197],...	193.0	[0..1]	[208..1]
gi\|194418491, gi... - gi\|83569861\|ref\|ZP_00921310.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Shigella dysente...	192.0	[0..1]	[208..1]
gi\|1098940 - gi\|1098940\|gb\|AAC43530.1\| thiol:disulfide interchange protein DsbA mutant PH31/32PS	191.0	[0..1]	[208..1]
gi\|110644199, gi... - gi\|110644199\|ref\|YP_671929.1\| periplasmic protein disulfide isomerase I [Escherichia coli 536], gi\|1... gi\|75237826, gi\|... - gi\|75237826\|ref\|ZP_00721841.1\| COG0526: Thiol-disulfide isomerase and thioredoxins [Escherichia coli...	191.0	[0..1]	[208..1]
gi\|927224 - gi\|927224\|dbj\|BAA07407.1\| disulfide oxidoreductase [Shigella flexneri]	188.0	[0..1]	[208..1]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKIWLALAG LVLAFSASAA QYEDGKQYTT LEKPVAGAPQ VLEFFSFFCP HCYQFEEVLH  60
   61 ISDNVKKKLP EGVKMTKYHV NFMGGDLGKD LTQAWAVAMA LGVEDKVTVP LFEGVQKTQT 120
  121 IRSASDIRDV FINAGIKGEE YDAAWNSFVV KSLVAQQEKA AADVQLRGVP AMFVNGKYQL 180
  181 NPQGMDTSNM DVFVQQYADT VKYLSEEK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.154902
Match:	1a23A
Description:	SOLUTION NMR STRUCTURE OF REDUCED DSBA FROM ESCHERICHIA COLI, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein disulfide isomerase activity	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds	1.48801287843472	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups	1.37876060576659	bayes_pls_golite062009
catalytic activity	1.04263226837398	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.25957505753521	bayes_pls_golite062009
isomerase activity	0.24662332270942	bayes_pls_golite062009
disulfide oxidoreductase activity	0.22354310938224	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: