YRC Public Data Repository - Protein Structure Prediction

Protein:	DHPS_SYNY3
Organism:	Synechocystis sp. PCC 6803
Length:	289 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHPS_SYNY3.

Description	E-value	Query Range	Subject Range
gi\|67925153, gi\|... - gi\|67925153\|ref\|ZP_00518525.1\| Dihydropteroate synthase [Crocosphaera watsonii WH 8501], gi\|67853000...	366.0	[0..14]	[289..3]
gi\|17231878, gi\|... - gi\|17231878\|ref\|NP_488426.1\| dihydropteroate synthase [Nostoc sp. PCC 7120], gi\|17133522\|dbj\|BAB7608... gi\|25287102 - pir\|\|AB2354 dihydropteroate synthase [imported] - Nostoc sp. (strain PCC 7120)	359.0	[0..13]	[289..3]
gi\|75909496, gi\|... - gi\|75909496\|ref\|YP_323792.1\| dihydropteroate synthase [Anabaena variabilis ATCC 29413], gi\|75703221\|...	359.0	[0..13]	[289..3]
gi\|78044228, gi\|... - gi\|78044228\|ref\|YP_361180.1\| dihydropteroate synthase [Carboxydothermus hydrogenoformans Z-2901], gi...	354.0	[0..15]	[289..28]
gi\|196251814, gi... - gi\|196251814\|ref\|ZP_03150480.1\| dihydropteroate synthase [Clostridium thermocellum DSM 4150], gi\|196... gi\|67873828, gi\|... - gi\|67873828\|ref\|ZP_00503815.1\| Dihydropteroate synthase [Clostridium thermocellum ATCC 27405], gi\|67...	351.0	[0..3]	[289..114]
gi\|186466895, gi... - gi\|23129521\|ref\|ZP_00111348.1\| COG0294: Dihydropteroate synthase and related enzymes [Nostoc punctif...	349.0	[0..12]	[289..2]
gi\|71677347, gi\|... - gi\|71677347\|ref\|ZP_00675085.1\| Dihydropteroate synthase [Trichodesmium erythraeum IMS101], gi\|716696...	342.0	[0..22]	[289..8]
gi\|22295247, gi\|... - gi\|22299065\|ref\|NP_682312.1\| dihydropteroate synthase [Thermosynechococcus elongatus BP-1], gi\|22295...	341.0	[0..15]	[289..4]
gi\|94426503, gi\|... - gi\|94501390\|ref\|ZP_01307910.1\| dihydropteroate synthase [Oceanobacter sp. RED65], gi\|94426503\|gb\|EAT...	339.0	[0..28]	[286..15]
gi\|88860505, gi\|... - gi\|88860505\|ref\|ZP_01135143.1\| Dihydropteroate synthase (DHPS) (Dihydropteroate pyrophosphorylase) [...	339.0	[0..15]	[286..4]

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Predicted Domain #1

Region A:
Residues: [1-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQLDQLSDY FPPPLPVGQT LFDWGKRTYV MGILNTTPDS FSDGGEFNSL PTAIHQAKTM  60
   61 VQGGAHIIDI GGQSTRPGAE TVSLKEELER TIPIIQALRQ ELDIPISIDT TRAEVARQAL 120
  121 QAGADMVNDI SGATFEPEIL AVAAQHKAPI ILMHIRGNPQ TMQNLTDYGD LIGEMRQFFS 180
  181 AQVDLARHYG VLPEQIILDP GIGFAKTAEQ NITLLRQLPE LKRLGFPLLV GPSRKSFIGK 240
  241 ILDQPDPKER VWGTGATCCR AIAGGADIVR VHDVEAMAQI CKVADALWR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.0
Match:	1twsA
Description:	Dihydropteroate Synthetase From Bacillus anthracis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dihydropteroate synthase activity	5.55484533231129	bayes_pls_golite062009
catalytic activity	1.94758748334979	bayes_pls_golite062009
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	1.59882258515727	bayes_pls_golite062009
transferase activity	1.09979615331123	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.09502814971491	bayes_pls_golite062009
binding	0.691846952184196	bayes_pls_golite062009
dihydroneopterin aldolase activity	0.570043482286316	bayes_pls_golite062009
diphosphotransferase activity	0.246882532482481	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: