YRC Public Data Repository - Protein Structure Prediction

Protein:	DCM_ECOLI
Organism:	Escherichia coli
Length:	472 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCM_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|237705920, gi... - gi\|237705920\|ref\|ZP_04536401.1\| DNA-cytosine methyltransferase [Escherichia sp. 3_2_53FAA], gi\|22690... gi\|227885611, gi... - gi\|227885611\|ref\|ZP_04003416.1\| DNA cytosine methylase [Escherichia coli 83972], gi\|227837184\|gb\|EEJ... gi\|26248232, gi\|... - gi\|26248232\|ref\|NP_754272.1\| DNA cytosine methylase [Escherichia coli CFT073], gi\|26108636\|gb\|AAN808...	404.0	[0..1]	[472..1]
gi\|218558817, gi... - gi\|218558817\|ref\|YP_002391730.1\| DNA cytosine methylase [Escherichia coli S88], gi\|218365586\|emb\|CAR... gi\|117624099, gi... - gi\|117624099\|ref\|YP_853012.1\| DNA cytosine methylase [Escherichia coli APEC O1], gi\|115513223\|gb\|ABJ... gi\|91211180, gi\|... - gi\|91211180\|ref\|YP_541166.1\| DNA cytosine methylase [Escherichia coli UTI89], gi\|91072754\|gb\|ABE0763...	403.0	[0..1]	[472..1]
gi\|110642066, gi... - gi\|110642066\|ref\|YP_669796.1\| DNA cytosine methylase [Escherichia coli 536], gi\|110343658\|gb\|ABG6989... gi\|191173268, gi... - gi\|75239146\|ref\|ZP_00723123.1\| COG0270: Site-specific DNA methylase [Escherichia coli F11], gi\|19117...	403.0	[0..1]	[472..1]
gi\|194430436, gi... - gi\|75208272\|ref\|ZP_00708629.1\| COG0270: Site-specific DNA methylase [Escherichia coli B171], gi\|1944...	402.0	[0..1]	[472..1]
gi\|75215146, gi\|... - gi\|75215146\|ref\|ZP_00713594.1\| COG0270: Site-specific DNA methylase [Escherichia coli E110019], gi\|1...	402.0	[0..1]	[472..1]
gi\|191169235, gi... - gi\|75227469\|ref\|ZP_00714236.1\| COG0270: Site-specific DNA methylase [Escherichia coli B7A], gi\|19116...	401.0	[0..1]	[472..1]
gi\|74312499, gi\|... - gi\|74312499\|ref\|YP_310918.1\| DNA cytosine methylase [Shigella sonnei Ss046], gi\|73855976\|gb\|AAZ88683...	401.0	[0..1]	[472..1]
gi\|75176956, gi\|... - gi\|75176956\|ref\|ZP_00697063.1\| COG0270: Site-specific DNA methylase [Shigella boydii BS512], gi\|1877...	401.0	[0..1]	[472..1]
gi\|81244992, gi\|... - gi\|82543581\|ref\|YP_407528.1\| DNA cytosine methylase [Shigella boydii Sb227], gi\|81244992\|gb\|ABB65700...	401.0	[0..1]	[472..1]
gi\|75190978, gi\|... - gi\|75190978\|ref\|ZP_00704245.1\| COG0270: Site-specific DNA methylase [Escherichia coli E24377A], gi\|1...	401.0	[0..1]	[472..1]

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Predicted Domain #1

Region A:
Residues: [1-83]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQENISVTDS YSTGNAAQAM LEKLLQIYDV KTLVAQLNGV GENHWSAAIL KRALANDSAW  60
   61 HRLSEKEFAH LQTLLPKPPA HHP

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.860	N/A	N/A	d.68.6	DNA-binding protein Sso10b (AlbA)

Predicted Domain #2

Region A:
Residues: [84-472]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYAFRFIDLF AGIGGIRRGF ESIGGQCVFT SEWNKHAVRT YKANHYCDPA THHFNEDIRD  60
   61 ITLSHKEGVS DEAAAEHIRQ HIPEHDVLLA GFPCQPFSLA GVSKKNSLGR AHGFACDTQG 120
  121 TLFFDVVRII DARRPAMFVL ENVKNLKSHD QGKTFRIIMQ TLDELGYDVA DAEDNGPDDP 180
  181 KIIDGKHFLP QHRERIVLVG FRRDLNLKAD FTLRDISECF PAQRVTLAQL LDPMVEAKYI 240
  241 LTPVLWKYLY RYAKKHQARG NGFGYGMVYP NNPQSVTRTL SARYYKDGAE ILIDRGWDMA 300
  301 TGEKDFDDPL NQQHRPRRLT PRECARLMGF EAPGEAKFRI PVSDTQAYRQ FGNSVVVPVF 360
  361 AAVAKLLEPK IKQAVALRQQ EAQHGRRSR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.0
Match:	10mhA
Description:	DNA methylase HhaI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-methyltransferase activity	3.31632172292823	bayes_pls_golite062009
transferase activity	2.42370637689376	bayes_pls_golite062009
methyltransferase activity	2.24556320310886	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	2.1789895493932	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	2.17404404470337	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.06810685308813	bayes_pls_golite062009
catalytic activity	1.62377578202456	bayes_pls_golite062009
RNA methyltransferase activity	1.36067005317038	bayes_pls_golite062009
rRNA methyltransferase activity	0.740099749645209	bayes_pls_golite062009
DNA (cytosine-5-)-methyltransferase activity	0.6110460718981	bayes_pls_golite062009
N-methyltransferase activity	0.49575399394607	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.0680860762896796	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: