YRC Public Data Repository - Protein Structure Prediction

Protein:	CYSM_ECOLI
Organism:	Escherichia coli
Length:	303 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYSM_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|73663552, gi\|... - gi\|73663552\|ref\|YP_302333.1\| cysteine synthase [Staphylococcus saprophyticus subsp. saprophyticus AT...	352.0	[0..1]	[295..6]
gi\|251806688, gi... - gi\|251809820\|ref\|ZP_04824293.1\| cysteine synthase [Staphylococcus epidermidis BCM-HMP0060], gi\|25180... gi\|242241598, gi... - gi\|242241598\|ref\|ZP_04796043.1\| cysteine synthase [Staphylococcus epidermidis W23144], gi\|242234979\|... CYSK_STAEQ - Cysteine synthase OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=cysK PE=3 SV=1 CYSK_STAEP - (Q8CMT6) Cysteine synthase (EC 2.5.1.47) (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyas... CYSK_STAES - Cysteine synthase OS=Staphylococcus epidermidis (strain ATCC 12228) GN=cysK PE=3 SV=1	350.0	[0..1]	[295..6]
gi\|191172928, gi... - gi\|191172928\|ref\|ZP_03034463.1\| cysteine synthase B [Escherichia coli F11], gi\|190906792\|gb\|EDV66396... gi\|110344196, gi... - gi\|110642604\|ref\|YP_670334.1\| cysteine synthase B [Escherichia coli 536], gi\|110344196\|gb\|ABG70433.1...	350.0	[0..1]	[303..1]
gi\|70727496, gi\|... - gi\|70727496\|ref\|YP_254412.1\| cysteine synthase [Staphylococcus haemolyticus JCSC1435], gi\|68448222\|d... gi\|228476212, gi... - gi\|228476212\|ref\|ZP_04060915.1\| cysteine synthase A [Staphylococcus hominis SK119], gi\|228269697\|gb\|...	349.0	[0..1]	[295..6]
gi\|26248797, gi\|... - gi\|26248797\|ref\|NP_754837.1\| cysteine synthase B [Escherichia coli CFT073], gi\|26109203\|gb\|AAN81405.... gi\|218366137, gi... - gi\|218559368\|ref\|YP_002392281.1\| cysteine synthase B [Escherichia coli S88], gi\|218366137\|emb\|CAR038... gi\|91211759, gi\|... - gi\|91211759\|ref\|YP_541745.1\| cysteine synthase B [Escherichia coli UTI89], gi\|91073333\|gb\|ABE08214.1...	349.0	[0..1]	[303..1]
gi\|209764164, gi... - gi\|209764164\|gb\|ACI80394.1\| cysteine synthase B [Escherichia coli], gi\|209764158\|gb\|ACI80391.1\| cyst... gi\|82777814, gi\|... - gi\|82777814\|ref\|YP_404163.1\| cysteine synthase B [Shigella dysenteriae Sd197], gi\|81241962\|gb\|ABB626...	349.0	[0..1]	[303..1]
gi\|168765217, gi... - gi\|189364963\|gb\|EDU83379.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4501], gi\|168765217... gi\|189362296, gi... - gi\|189362296\|gb\|EDU80715.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4486], gi\|168768512... gi\|187770660, gi... - gi\|187770660\|gb\|EDU34504.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4196], gi\|168773667... gi\|189003346, gi... - gi\|189003346\|gb\|EDU72332.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4076], gi\|168778386... gi\|188017126, gi... - gi\|188017126\|gb\|EDU55248.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4113], gi\|168748522... gi\|168756191, gi... - gi\|189356584\|gb\|EDU75003.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4401], gi\|168756191... gi\|13362762, gi\|... - gi\|15832546\|ref\|NP_311319.1\| cysteine synthase B [Escherichia coli O157:H7 str. Sakai], gi\|13362762\|... gi\|13362762, gi\|... - gi\|15832546\|ref\|NP_311319.1\| cysteine synthase B [Escherichia coli O157:H7], gi\|13362762\|dbj\|BAB3671... gi\|208812932, gi... - gi\|208812932\|ref\|ZP_03254261.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|209764166, gi... - pir\|\|G85884 cysteine synthase (EC 4.2.99.8) [similarity] - Escherichia coli (strain O157:H7, substra... gi\|208740083, gi... - gi\|208819960\|ref\|ZP_03260280.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4042], gi\|20874... gi\|209158565, gi... - gi\|209397165\|ref\|YP_002271898.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4115], gi\|2091... gi\|15802953, gi\|... - gi\|15802953\|ref\|NP_288982.1\| cysteine synthase B [Escherichia coli O157:H7 EDL933], gi\|12516796\|gb\|A... gi\|217319427, gi... - gi\|217327060\|ref\|ZP_03443143.1\| cysteine synthase B [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|189372367, gi... - gi\|189372367\|gb\|EDU90783.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC869], gi\|168787767\|... gi\|254593774, gi... - gi\|254794374\|ref\|YP_003079211.1\| cysteine synthase B (O-acetylserine sulfhydrolase B) [Escherichia c... gi\|168798791, gi... - gi\|189378636\|gb\|EDU97052.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC508], gi\|168798791\|... gi\|195936572 - gi\|195936572\|ref\|ZP_03081954.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4024] gi\|208806831, gi... - gi\|208806831\|ref\|ZP_03249168.1\| cysteine synthase B [Escherichia coli O157:H7 str. EC4206], gi\|20872...	349.0	[0..1]	[303..1]
gi\|74312957, gi\|... - gi\|74312957\|ref\|YP_311376.1\| cysteine synthase B [Shigella sonnei Ss046], gi\|73856434\|gb\|AAZ89141.1\|... gi\|218352788, gi... - gi\|218696056\|ref\|YP_002403723.1\| cysteine synthase B [Escherichia coli 55989], gi\|218352788\|emb\|CAU9... gi\|218554953, gi... - gi\|218554953\|ref\|YP_002387866.1\| cysteine synthase B [Escherichia coli IAI1], gi\|218361721\|emb\|CAQ99... gi\|194427304, gi... - gi\|194427304\|ref\|ZP_03059854.1\| cysteine synthase B [Escherichia coli B171], gi\|194414625\|gb\|EDX3089... gi\|192927578, gi... - gi\|193064695\|ref\|ZP_03045773.1\| cysteine synthase B [Escherichia coli E22], gi\|192927578\|gb\|EDV82194... gi\|191168980, gi... - gi\|191168980\|ref\|ZP_03030747.1\| cysteine synthase B [Escherichia coli B7A], gi\|190900987\|gb\|EDV60769... gi\|157078515, gi... - gi\|157156485\|ref\|YP_001463750.1\| cysteine synthase B [Escherichia coli E24377A], gi\|157078515\|gb\|ABV...	349.0	[0..1]	[303..1]
gi\|36784774, gi\|... - gi\|37525347\|ref\|NP_928691.1\| cysteine synthase B [Photorhabdus luminescens subsp. laumondii TTO1], g...	349.0	[0..1]	[293..1]
gi\|227247508, gi... - gi\|227556072\|ref\|ZP_03986119.1\| cysteine synthase (o-acetylserine sulfhydrylase) family protein [Sta... gi\|269202133\|ref... - cysteine synthase [Staphylococcus aureus subsp. aureus ED98] gi\|253315218 - gi\|253315218\|ref\|ZP_04838431.1\| cysteine synthase A [Staphylococcus aureus subsp. aureus str. CF-Mar... gi\|253730981, gi... - gi\|253730981\|ref\|ZP_04865146.1\| cysteine synthase (o-acetylserine sulfhydrylase) family protein [Sta... gi\|227900600, gi... - gi\|227900600\|ref\|ZP_04018405.1\| cysteine synthase (o-acetylserine sulfhydrylase) family protein [Sta... gi\|251804219, gi... - gi\|251812231\|ref\|ZP_04826704.1\| cysteine synthase (o-acetylserine sulfhydrylase) family protein [Sta... gi\|25291764 - pir\|\|B89818 cysteine synthase (EC 4.2.99.8) [similarity] - Staphylococcus aureus (strain N315) gi\|151220687, gi... - gi\|151220687\|ref\|YP_001331509.1\| cysteine synthase-like protein [Staphylococcus aureus subsp. aureus... CYSK_STAAR - Cysteine synthase OS=Staphylococcus aureus (strain MRSA252) GN=cysK PE=3 SV=1 gi\|87201831, gi\|... - gi\|88194273\|ref\|YP_499065.1\| hypothetical protein SAOUHSC_00488 [Staphylococcus aureus subsp. aureus... gi\|253735248, gi... - gi\|253735248\|ref\|ZP_04869413.1\| cysteine synthase (o-acetylserine sulfhydrylase) family protein [Sta... CYSK_STAAW - Cysteine synthase OS=Staphylococcus aureus (strain MW2) GN=cysK PE=3 SV=1 gi\|87126032, gi\|... - gi\|87160058\|ref\|YP_493200.1\| cysteine synthase A [Staphylococcus aureus subsp. aureus USA300_FPR3757... gi\|255005306 - gi\|255005306\|ref\|ZP_05143907.2\| cysteine synthase A [Staphylococcus aureus subsp. aureus Mu50-omega] CYSK_STAAN - Cysteine synthase OS=Staphylococcus aureus (strain N315) GN=cysK PE=1 SV=1 CYSK_STAAM - Cysteine synthase OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=cysK PE=3 SV=1 CYSK_STAAC - Cysteine synthase OS=Staphylococcus aureus (strain COL) GN=cysK PE=3 SV=1 CYSK_STAAS - Cysteine synthase OS=Staphylococcus aureus (strain MSSA476) GN=cysK PE=3 SV=1 gi\|156978841, gi... - gi\|156978841\|ref\|YP_001441100.1\| cysteine synthase #o-acetylserine sulfhydrylase homologue [Staphylo... gi\|161508753, gi... - gi\|161508753\|ref\|YP_001574412.1\| cysteine synthase [Staphylococcus aureus subsp. aureus USA300_TCH15... gi\|221142295 - gi\|221142295\|ref\|ZP_03566788.1\| cysteine synthase [Staphylococcus aureus subsp. aureus str. JKD6009] gi\|87126032\|gb\|A... - cysteine synthase A [Staphylococcus aureus subsp. aureus USA300], cysteine synthase A [Staphylococcu... gi\|221138562 - gi\|221138562\|ref\|ZP_03563364.1\| cysteine synthase [Staphylococcus aureus subsp. aureus str. JKD6008]	349.0	[0..1]	[295..6]

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Predicted Domain #1

Region A:
Residues: [1-303]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLEQTIGN TPLVKLQRMG PDNGSEVWLK LEGNNPAGSV KDRAALSMIV EAEKRGEIKP  60
   61 GDVLIEATSG NTGIALAMIA ALKGYRMKLL MPDNMSQERR AAMRAYGAEL ILVTKEQGME 120
  121 GARDLALEMA NRGEGKLLDQ FNNPDNPYAH YTTTGPEIWQ QTGGRITHFV SSMGTTGTIT 180
  181 GVSRFMREQS KPVTIVGLQP EEGSSIPGIR RWPTEYLPGI FNASLVDEVL DIHQRDAENT 240
  241 MRELAVREGI FCGVSSGGAV AGALRVAKAN PDAVVVAIIC DRGDRYLSTG VFGEEHFSQG 300
  301 AGI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	96.69897
Match:	2bhtA
Description:	Crystal Structure
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cysteine synthase activity	5.18562032111987	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
cystathionine beta-synthase activity	1.4517088142802	bayes_pls_golite062009
tryptophan synthase activity	1.04832999357666	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
threonine synthase activity	0.727838845253199	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: