YRC Public Data Repository - Protein Structure Prediction

Protein:	CUTC_ECOLI
Organism:	Escherichia coli
Length:	248 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUTC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|62901834 - gi\|62901834\|gb\|AAY18868.1\| CGI-32 [synthetic construct]	381.0	[0..3]	[243..38]
gi\|109463988, gi... - gi\|62642320\|ref\|XP_342053.2\| PREDICTED: similar to Copper homeostasis protein cutC homolog [Rattus n...	380.0	[0..3]	[243..26]
ENSPTRT00000005383 - null CUTC - cutC copper transporter homolog (E. coli)	379.0	[0..3]	[243..27]
gi\|109090222 - gi\|109090222\|ref\|XP_001106529.1\| PREDICTED: cutC copper transporter homolog [Macaca mulatta]	378.0	[0..3]	[243..27]
CUTC_MOUSE - Copper homeostasis protein cutC homolog OS=Mus musculus GN=Cutc PE=1 SV=1	377.0	[0..3]	[243..26]
gi\|73998621 - gi\|73998621\|ref\|XP_534987.2\| PREDICTED: similar to Copper homeostasis protein cutC homolog [Canis fa...	368.0	[0..3]	[243..27]
CUTC_ECOLC - Copper homeostasis protein CutC OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=cutC P... gi\|253324213, gi... - gi\|253773169\|ref\|YP_003036000.1\| CutC family protein [Escherichia coli BL21(DE3)], gi\|253324213\|gb\|A... gi\|188494667, gi... - gi\|75513021\|ref\|ZP_00735483.1\| COG3142: Uncharacterized protein involved in copper resistance [Esche... gi\|124531081, gi... - gi\|124531081\|ref\|ZP_01701466.1\| CutC family protein [Escherichia coli B], gi\|124498820\|gb\|EAY46322.1... gi\|242377595, gi... - gi\|251785322\|ref\|YP_002999626.1\| hypothetical protein B21_01834 [Escherichia coli BL21], gi\|24237759... CUTC_ECOHS - Copper homeostasis protein CutC OS=Escherichia coli O9:H4 (strain HS) GN=cutC PE=3 SV=1 gi\|194422042, gi... - gi\|83585525\|ref\|ZP_00924169.1\| COG3142: Uncharacterized protein involved in copper resistance [Esche...	357.0	[0..1]	[248..1]
gi\|61680308, gi\|... - gi\|61680308\|pdb\|1X7I\|B Chain B, Crystal Structure Of The Native Copper Homeostasis Protein (Cutcm) W...	357.0	[0..1]	[248..1]
CUTC_ECO27 - Copper homeostasis protein CutC OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cutC PE=3 SV... sp\|B7USQ1\|CUTC_ECO27 - Copper homeostasis protein CutC OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=cutC PE=3 SV... gi\|190906750, gi... - gi\|75239705\|ref\|ZP_00723668.1\| COG3142: Uncharacterized protein involved in copper resistance [Esche... CUTC_ECOL5 - Copper homeostasis protein CutC OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=cutC PE=3 SV=1 CUTC_ECOL6 - Copper homeostasis protein CutC OS=Escherichia coli O6 GN=cutC PE=3 SV=1 CUTC_ECOL6 - Copper homeostasis protein CutC OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=cu...	357.0	[0..1]	[248..1]

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Predicted Domain #1

Region A:
Residues: [1-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLEICCYS MECALTAQQN GADRVELCAA PKEGGLTPSL GVLKSVRQRV TIPVHPIIRP  60
   61 RGGDFCYSDG EFAAILEDVR TVRELGFPGL VTGVLDVDGN VDMPRMEKIM AAAGPLAVTF 120
  121 HRAFDMCANP LYTLNNLAEL GIARVLTSGQ KSDALQGLSK IMELIAHRDA PIIMAGAGVR 180
  181 AENLHHFLDA GVLEVHSSAG AWQASPMRYR NQGLSMSSDE HADEYSRYIV DGAAVAEMKG 240
  241 IIERHQAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	99.0
Match:	1twdA
Description:	Crystal Structure of the Putative Copper Homeostasis Protein (CutC) from Shigella flexneri, Northeast Structural Genomics Target SfR33
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
copper ion binding	2.32959091323982	bayes_pls_golite062009
binding	1.75231237460254	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: