YRC Public Data Repository - Protein Structure Prediction

Protein:	CPXA_ECOLI
Organism:	Escherichia coli
Length:	457 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPXA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|20808918 - gi\|20808918\|ref\|NP_624089.1\| Sensory transduction histidine kinase [Thermoanaerobacter tengcongensis... gi\|20808918, gi\|... - gi\|20808918\|ref\|NP_624089.1\| sensory transduction histidine kinase [Thermoanaerobacter tengcongensis...	276.0	[0..2]	[455..3]
gi\|77977377 - gi\|77977377\|ref\|ZP_00832827.1\| COG0642: Signal transduction histidine kinase [Yersinia intermedia AT...	274.0	[0..1]	[455..1]
gi\|222053516, gi... - gi\|222053516\|ref\|YP_002535878.1\| histidine kinase [Geobacter sp. FRC-32], gi\|221562805\|gb\|ACM18777.1...	272.0	[0..2]	[456..4]
gi\|77960031 - gi\|77960031\|ref\|ZP_00823931.1\| COG0642: Signal transduction histidine kinase [Yersinia mollaretii AT...	272.0	[0..1]	[455..1]
gi\|27544277 - gi\|27544277\|dbj\|BAC54912.1\| chemosensory transducer [Yersinia pseudotuberculosis] gi\|25298451 - pir\|\|AI0009 two component sensor kinase (EC 2.7.3.-) [imported] - Yersinia pestis (strain CO92) gi\|45434792, gi\|... - gi\|45439937\|ref\|NP_991476.1\| two-component sensor protein [Yersinia pestis biovar Microtus str. 9100... gi\|167426641, gi... - gi\|167426641\|ref\|ZP_02318394.1\| sensor protein CpxA [Yersinia pestis biovar Mediaevalis str. K197300... gi\|21956729, gi\|... - gi\|22123989\|ref\|NP_667412.1\| two-component sensor protein [Yersinia pestis KIM], gi\|21956729\|gb\|AAM8... gi\|229904467, gi... - gi\|229904467\|ref\|ZP_04519578.1\| sensory histidine kinase in two-component regulatory system with Cpx... gi\|167468391 - gi\|167468391\|ref\|ZP_02333095.1\| sensor protein CpxA [Yersinia pestis FV-1] gi\|218927292, gi... - gi\|218927292\|ref\|YP_002345167.1\| two-component sensor protein [Yersinia pestis CO92], gi\|16120424\|re... gi\|108781374, gi... - gi\|108809461\|ref\|YP_653377.1\| two-component sensor protein [Yersinia pestis Antiqua], gi\|108781374\|g... gi\|169752874, gi... - gi\|170026340\|ref\|YP_001722845.1\| two-component sensor protein [Yersinia pseudotuberculosis YPIII], g... gi\|51594427, gi\|... - gi\|51594427\|ref\|YP_068618.1\| two-component sensor protein [Yersinia pseudotuberculosis IP 32953], gi... gi\|186893414, gi... - gi\|186893414\|ref\|YP_001870526.1\| two-component sensor protein [Yersinia pseudotuberculosis PB1/+], g... gi\|152960360, gi... - gi\|153948865\|ref\|YP_001399084.1\| two-component sensor protein [Yersinia pseudotuberculosis IP 31758]... gi\|150260865, gi... - gi\|150260865\|ref\|ZP_01917593.1\| sensory histidine kinase in two-component regulatory system with Cpx... gi\|145601073, gi... - gi\|145601073\|ref\|YP_001165149.1\| two-component sensor protein [Yersinia pestis Pestoides F], gi\|1452... gi\|229842004, gi... - gi\|229842004\|ref\|ZP_04462159.1\| sensory histidine kinase in two-component regulatory system with Cpx... gi\|229706634, gi... - gi\|229836186\|ref\|ZP_04456354.1\| sensory histidine kinase in two-component regulatory system with Cpx... gi\|229839922, gi... - gi\|229839922\|ref\|ZP_04460081.1\| sensory histidine kinase in two-component regulatory system with Cpx... gi\|166011480, gi... - gi\|166011480\|ref\|ZP_02232378.1\| sensor protein CpxA [Yersinia pestis biovar Antiqua str. E1979001], ... gi\|166205122, gi... - gi\|166213720\|ref\|ZP_02239755.1\| sensor protein CpxA [Yersinia pestis biovar Antiqua str. B42003004],... gi\|167051493, gi... - gi\|167398989\|ref\|ZP_02304513.1\| sensor protein CpxA [Yersinia pestis biovar Antiqua str. UG05-0454],... gi\|167418855, gi... - gi\|167418855\|ref\|ZP_02310608.1\| sensor protein CpxA [Yersinia pestis biovar Orientalis str. MG05-102... gi\|162419902, gi... - gi\|162419902\|ref\|YP_001604718.1\| two-component sensor protein [Yersinia pestis Angola], gi\|162352717... gi\|165922023, gi... - gi\|165926163\|ref\|ZP_02221995.1\| sensor protein CpxA [Yersinia pestis biovar Orientalis str. F1991016... gi\|165915863, gi... - gi\|165936249\|ref\|ZP_02224818.1\| sensor protein CpxA [Yersinia pestis biovar Orientalis str. IP275], ...	271.0	[0..1]	[455..1]
gi\|77958482 - gi\|77958482\|ref\|ZP_00822515.1\| COG0642: Signal transduction histidine kinase [Yersinia bercovieri AT...	270.0	[0..1]	[455..1]
gi\|78224572, gi\|... - gi\|78224572\|ref\|YP_386319.1\| heavy metal sensor signal transduction histidine kinase [Geobacter meta...	270.0	[0..2]	[454..3]
gi\|75513938, gi\|... - gi\|75513938\|ref\|ZP_00736291.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638...	269.0	[0..1]	[457..1]
gi\|75176703, gi\|... - gi\|75176703\|ref\|ZP_00696831.1\| COG0642: Signal transduction histidine kinase [Shigella boydii BS512]...	269.0	[0..1]	[457..1]

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Predicted Domain #1

Region A:
Residues: [1-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGSLTARIF AIFWLTLALV LMLVLMLPKL DSRQMTELLD SEQRQGLMIE QHVEAELAND  60
   61 PPNDLMWWRR LFRAIDKWAP PGQRLLLVTT EGRVIGAERS EMQIIRNFIG QADNADHPQK 120
  121 KKYGRVELVG PFSVRD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.539	a.24.17	Group V grass pollen allergen
View	Download	0.473	a.2.5	Prefoldin
View	Download	0.420	a.2.5	Prefoldin
View	Download	0.401	d.218.1	Nucleotidyltransferase
View	Download	0.395	a.79.1	Antitermination factor NusB

Predicted Domain #2

Region A:
Residues: [137-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEDNYQLYLI RPASSSQSDF INLLFDRPLL LLIVTMLVST PLLLWLAWSL AKPARKLKNA  60
   61 ADEVAQGNLR QHPELEA

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.3
Match:	2f95B
Description:	M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [214-457]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPQEFLAAGA SFNQMVTALE RMMTSQQRLL SDISHELRTP LTRLQLGTAL LRRRSGESKE  60
   61 LERIETEAQR LDSMINDLLV MSRNQQKNAL VSETIKANQL WSEVLDNAAF EAEQMGKSLT 120
  121 VNFPPGPWPL YGNPNALESA LENIVRNALR YSHTKIEVGF AVDKDGITIT VDDDGPGVSP 180
  181 EDREQIFRPF YRTDEARDRE SGGTGLGLAI VETAIQQHRG WVKAEDSPLG GLRLVIWLPL 240
  241 YKRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.522879
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits