YRC Public Data Repository - Protein Structure Prediction

Protein:	CPSF2
Organism:	Homo sapiens
Length:	782 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CPSF2.

Description	E-value	Query Range	Subject Range
gi\|109084634 - gi\|109084634\|ref\|XP_001092942.1\| PREDICTED: similar to cleavage and polyadenylation specific factor ...	0.0	[1..782]	[1..782]
CPSF2_BOVIN - Cleavage and polyadenylation specificity factor subunit 2 OS=Bos taurus GN=CPSF2 PE=1 SV=1	0.0	[1..782]	[1..782]
gi\|47125306 - gi\|47125306\|gb\|AAH70095.1\| Cleavage and polyadenylation specific factor 2, 100kDa [Homo sapiens]	0.0	[1..782]	[1..782]
gi\|73962293 - gi\|73962293\|ref\|XP_537353.2\| PREDICTED: similar to cleavage and polyadenylation specific factor 2 is...	0.0	[1..782]	[1..782]
gi\|157822735, gi... - ref\|XP_216766.2\| similar to cleavage and polyadenylation specificity factor [Rattus norvegicus], gi\|...	0.0	[1..782]	[1..782]
CPSF2_MOUSE - Cleavage and polyadenylation specificity factor subunit 2 OS=Mus musculus GN=Cpsf2 PE=1 SV=1	0.0	[1..782]	[1..782]
CPSF2_XENLA - Cleavage and polyadenylation specificity factor subunit 2 OS=Xenopus laevis GN=cpsf2 PE=1 SV=1	0.0	[1..782]	[1..783]
gi\|60098929, gi\|... - gi\|71894931\|ref\|NP_001026379.1\| cleavage and polyadenylation specific factor 2 [Gallus gallus], gi\|6...	0.0	[1..782]	[1..782]

Back

Predicted Domain #1

Region A:
Residues: [1-453]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIIKLTTL SGVQEESALC YLLQVDEFRF LLDCGWDEHF SMDIIDSLRK HVHQIDAVLL  60
   61 SHPDPLHLGA LPYAVGKLGL NCAIYATIPV YKMGQMFMYD LYQSRHNTED FTLFTLDDVD 120
  121 AAFDKIQQLK FSQIVNLKGK GHGLSITPLP AGHMIGGTIW KIVKDGEEEI VYAVDFNHKR 180
  181 EIHLNGCSLE MLSRPSLLIT DSFNATYVQP RRKQRDEQLL TNVLETLRGD GNVLIAVDTA 240
  241 GRVLELAQLL DQIWRTKDAG LGVYSLALLN NVSYNVVEFS KSQVEWMSDK LMRCFEDKRN 300
  301 NPFQFRHLSL CHGLSDLARV PSPKVVLASQ PDLECGFSRD LFIQWCQDPK NSIILTYRTT 360
  361 PGTLARFLID NPSEKITEIE LRKRVKLEGK ELEEYLEKEK LKKEAAKKLE QSKEADIDSS 420
  421 DESDIEEDID QPSAHKTKHD LMMKGEGSRK GSF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.39794
Match:	2i7tA
Description:	No description for 2i7tA was found.

Predicted Domain #2

Region A:
Residues: [454-662]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKQAKKSYPM FPAPEERIKW DEYGEIIKPE DFLVPELQAT EEEKSKLESG LTNGDEPMDQ  60
   61 DLSDVPTKCI STTESIEIKA RVTYIDYEGR SDGDSIKKII NQMKPRQLII VHGPPEASQD 120
  121 LAECCRAFGG KDIKVYMPKL HETVDATSET HIYQVRLKDS LVSSLQFCKA KDAELAWIDG 180
  181 VLDMRVSKVD TGVILEEGEL KDDGEDSEM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.21
Match:	2i7xA
Description:	No description for 2i7xA was found.

Predicted Domain #3

Region A:
Residues: [663-782]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVEAPSDSSV IAQQKAMKSL FGDDEKETGE ESEIIPTLEP LPPHEVPGHQ SVFMNEPRLS  60
   61 DFKQVLLREG IQAEFVGGVL VCNNQVAVRR TETGRIGLEG CLCQDFYRIR DLLYEQYAIV 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.564	a.77.1	DEATH domain
View	Download	0.516	a.60.1	SAM/Pointed domain
View	Download	0.497	d.95.2	Homing endonucleases
View	Download	0.508	d.94.1	HPr-like
View	Download	0.503	d.105.1	Clathrin adaptor appendage, alpha and beta chain-specific domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits