YRC Public Data Repository - Protein Structure Prediction

Protein:	COBT_ECOLI
Organism:	Escherichia coli
Length:	359 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COBT_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91708441, gi\|... - gi\|91774454\|ref\|YP_544210.1\| nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase [...	434.0	[0..10]	[353..12]
COBT_CHLTE - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Chlorobium tepidum GN=cobT... COBT_CHLTE - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Chlorobium tepidum (strain...	431.0	[0..1]	[350..1]
COBT_PHOPR - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Photobacterium profundum G... COBT_PHOPR - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Photobacterium profundum (...	428.0	[0..10]	[348..3]
gi\|90413242, gi\|... - gi\|90413242\|ref\|ZP_01221237.1\| nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferas...	427.0	[0..10]	[348..3]
COBT_LEPIN - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Leptospira interrogans GN=... COBT_LEPIN - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Leptospira interrogans ser...	427.0	[0..14]	[350..3]
COBT_LEPIC - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Leptospira interrogans ser... COBT_LEPIC - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Leptospira interrogans ser...	426.0	[0..14]	[350..3]
COBT_GEOSL - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Geobacter sulfurreducens (... COBT_GEOSL - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Geobacter sulfurreducens G...	425.0	[0..1]	[351..1]
COBT_DESRM - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Desulfotomaculum reducens ...	425.0	[0..1]	[348..1]
COBT_GEOUR - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase OS=Geobacter uraniireducens (...	425.0	[0..1]	[349..1]
gi\|189346598, gi... - gi\|67919222\|ref\|ZP_00512806.1\| Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase...	421.0	[0..1]	[350..4]

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Predicted Domain #1

Region A:
Residues: [1-359]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQILADLLNT IPAIDSTAMS RAQRHIDGLL KPVGSLGKLE VLAIQLAGMP GLNGIPHVGK  60
   61 KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAEQAGANV HVIDVGIDTA 120
  121 EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT QELAKNGVTL FGVGELGMAN 180
  181 TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG 240
  241 GFDLVGIAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA 300
  301 LSHLGLEPYL NMEMRLGEGS GAALAMPIIE AACAIYNNMG ELAASNIVLP GNTTSDLNS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0
Match:	1jh8A
Description:	Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity	6.11307440325985	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.4037591171855	bayes_pls_golite062009
catalytic activity	2.05174935916901	bayes_pls_golite062009
transferase activity	1.06150708725398	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	0.819573960721987	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: