YRC Public Data Repository - Protein Structure Prediction

Protein:	CLS_ECOLI
Organism:	Escherichia coli
Length:	486 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLS_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|77960752 - gi\|77960752\|ref\|ZP_00824610.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	383.0	[0..1]	[486..1]
CLS_YERPS - Cardiolipin synthase OS=Yersinia pseudotuberculosis GN=cls PE=3 SV=1 CLSA_YERPB - Cardiolipin synthase A OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=clsA PE=3 SV=1 CLSA_YERPS - Cardiolipin synthase A OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=clsA PE=3 SV=1	383.0	[0..1]	[486..1]
gi\|149365891, gi... - gi\|149365891\|ref\|ZP_01887926.1\| cardiolipin synthetase [Yersinia pestis CA88-4125], gi\|149292304\|gb\|... gi\|16122418, gi\|... - gi\|218929286\|ref\|YP_002347161.1\| cardiolipin synthetase [Yersinia pestis CO92], gi\|16122418\|ref\|NP_4... CLSA_YERPP - Cardiolipin synthase A OS=Yersinia pestis (strain Pestoides F) GN=clsA PE=3 SV=1 CLSA_YERPG - Cardiolipin synthase A OS=Yersinia pestis bv. Antiqua (strain Angola) GN=clsA PE=3 SV=1 CLSA_YERP3 - Cardiolipin synthase A OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=clsA PE=3 S... gi\|166961781, gi... - gi\|167420086\|ref\|ZP_02311839.1\| cardiolipin synthetase [Yersinia pestis biovar Orientalis str. MG05-... gi\|167425026, gi... - gi\|167425026\|ref\|ZP_02316779.1\| cardiolipin synthetase [Yersinia pestis biovar Mediaevalis str. K197... gi\|229688545, gi... - gi\|229898255\|ref\|ZP_04513402.1\| cardiolipin synthase 1 [Yersinia pestis biovar Orientalis str. India... gi\|229693947, gi... - gi\|229897610\|ref\|ZP_04512766.1\| cardiolipin synthase 1 [Yersinia pestis biovar Orientalis str. PEXU2... CLSA_YERPE - Cardiolipin synthase A OS=Yersinia pestis GN=clsA PE=3 SV=1 gi\|229894864, gi... - gi\|229894864\|ref\|ZP_04510043.1\| cardiolipin synthase 1 [Yersinia pestis Pestoides A], gi\|229702157\|g... gi\|89104999, gi\|... - gi\|89104999\|ref\|ZP_01177527.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ... CLSA_YERPA - Cardiolipin synthase A OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=clsA PE=3 SV=1 CLSA_YERPN - Cardiolipin synthase A OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=clsA PE=3 SV=1 gi\|165920682, gi... - gi\|165927416\|ref\|ZP_02223248.1\| cardiolipin synthetase [Yersinia pestis biovar Orientalis str. F1991... gi\|166009253, gi... - gi\|166009253\|ref\|ZP_02230151.1\| cardiolipin synthetase [Yersinia pestis biovar Antiqua str. E1979001... gi\|166211179, gi... - gi\|166211179\|ref\|ZP_02237214.1\| cardiolipin synthetase [Yersinia pestis biovar Antiqua str. B4200300... gi\|167049832, gi... - gi\|167400979\|ref\|ZP_02306485.1\| cardiolipin synthetase [Yersinia pestis biovar Antiqua str. UG05-045...	382.0	[0..1]	[486..1]
gi\|77972671, gi\|... - gi\|77972671\|ref\|ZP_00828231.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	382.0	[0..1]	[486..1]
gi\|22125925, gi\|... - gi\|22125925\|ref\|NP_669348.1\| cardiolipin synthetase [Yersinia pestis KIM], gi\|21958864\|gb\|AAM85599.1... gi\|45441787, gi\|... - gi\|45441787\|ref\|NP_993326.1\| cardiolipin synthetase [Yersinia pestis biovar Microtus str. 91001], gi...	381.0	[0..1]	[486..8]
gi\|77977781, gi\|... - gi\|77977781\|ref\|ZP_00833221.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	380.0	[0..1]	[486..1]
gi\|77957084, gi\|... - gi\|77957084\|ref\|ZP_00821150.1\| COG1502: Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin ...	379.0	[0..1]	[486..1]
CLSA_PECAS - Cardiolipin synthase A OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=clsA PE=3... CLS_ERWCT - Cardiolipin synthase OS=Erwinia carotovora subsp. atroseptica GN=cls PE=3 SV=1	377.0	[0..1]	[486..1]
gi\|56963585, gi\|... - gi\|56963585\|ref\|YP_175316.1\| cardiolipin synthetase [Bacillus clausii KSM-K16], gi\|56909828\|dbj\|BAD6...	376.0	[0..5]	[486..7]
CLSA_SODGM - Cardiolipin synthase A OS=Sodalis glossinidius (strain morsitans) GN=clsA PE=3 SV=1	375.0	[0..1]	[486..1]

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Predicted Domain #1

Region A:
Residues: [1-60]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTVYTLVSW LAILGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV GIIAYLAVGE  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [61-486]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSSVA APLFKLCERR QGIAGVKGNQ  60
   61 LQLMTESDDV MQALIRDIQL ARHNIEMVFY IWQPGGMADQ VAESLMAAAR RGIHCRLMLD 120
  121 SAGSVAFFRS PWPELMRNAG IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM 180
  181 NMVDPRYFKQ DAGVGQWIDL MARMEGPIAT AMGIIYSCDW EIETGKRILP PPPDVNIMPF 240
  241 EQASGHTIHT IASGPGFPED LIHQALLTAA YSAREYLIMT TPYFVPSDDL LHAICTAAQR 300
  301 GVDVSIILPR KNDSMLVGWA SRAFFTELLA AGVKIYQFEG GLLHTKSVLV DGELSLVGTV 360
  361 NLDMRSLWLN FEITLAIDDK GFGADLAAVQ DDYISRSRLL DARLWLKRPL WQRVAERLFY 420
  421 FFSPLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.522879
Match:	1xdoA
Description:	Crystal Structure of Escherichia coli Polyphosphate Kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoric diester hydrolase activity	1.55477881010087	bayes_pls_golite062009
catalytic activity	1.29236214516383	bayes_pls_golite062009
binding	0.66572565048579	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.486367378916393	bayes_pls_golite062009
protein binding	0.162885453822356	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: