YRC Public Data Repository - Protein Structure Prediction

Protein:	CHEA_ECOLI
Organism:	Escherichia coli
Length:	654 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHEA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|145529 - gi\|145529\|gb\|AAA23573.1\| CheA protein (alt.)	415.0	[0..1]	[654..1]
gi\|209767230, gi... - pir\|\|B85802 hypothetical protein cheA [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|12515952, gi\|... - gi\|15802300\|ref\|NP_288325.1\| chemotaxis protein CheA [Escherichia coli O157:H7 EDL933], gi\|12515952\|... gi\|13362066, gi\|... - gi\|15831852\|ref\|NP_310625.1\| CheA [Escherichia coli O157:H7], gi\|13362066\|dbj\|BAB36021.1\| sensory tr... gi\|13362066, gi\|... - gi\|15831852\|ref\|NP_310625.1\| chemotaxis protein CheA [Escherichia coli O157:H7 str. Sakai], gi\|13362... gi\|254793512, gi... - gi\|254793512\|ref\|YP_003078349.1\| sensory transducer kinase between chemo- signal receptors and CheB ...	412.0	[0..1]	[654..1]
gi\|56383547, gi\|... - gi\|56479996\|ref\|NP_707783.2\| chemotaxis protein CheA [Shigella flexneri 2a str. 301], gi\|56383547\|gb... gi\|30063340, gi\|... - gi\|30063340\|ref\|NP_837511.1\| chemotaxis protein CheA [Shigella flexneri 2a str. 2457T], gi\|30041592\|... gi\|110805868, gi... - gi\|110805868\|ref\|YP_689388.1\| chemotaxis protein CheA [Shigella flexneri 5 str. 8401], gi\|110615416\|...	412.0	[0..1]	[654..1]
gi\|74311762, gi\|... - gi\|74311762\|ref\|YP_310181.1\| chemotaxis protein CheA [Shigella sonnei Ss046], gi\|73855239\|gb\|AAZ8794...	410.0	[0..1]	[654..1]
gi\|26248155, gi\|... - gi\|26248155\|ref\|NP_754195.1\| chemotaxis protein CheA [Escherichia coli CFT073], gi\|26108559\|gb\|AAN80...	409.0	[0..2]	[654..20]
gi\|124498833, gi... - gi\|124531094\|ref\|ZP_01701479.1\| CheA signal transduction histidine kinases [Escherichia coli B], gi\|... gi\|75513035 - gi\|75513035\|ref\|ZP_00735497.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc... gi\|192926887, gi... - gi\|75256496\|ref\|ZP_00728142.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc... gi\|170683477, gi... - gi\|170683477\|ref\|YP_001743354.1\| chemotaxis protein CheA [Escherichia coli SMS-3-5], gi\|170521195\|gb... gi\|75235308, gi\|... - gi\|75235308\|ref\|ZP_00719534.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc... gi\|75209435, gi\|... - gi\|75209435\|ref\|ZP_00709663.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc... gi\|194422009, gi... - gi\|83585512\|ref\|ZP_00924156.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc...	408.0	[0..3]	[654..1]
gi\|75228731 - gi\|75228731\|ref\|ZP_00715344.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc...	407.0	[0..3]	[654..1]
gi\|115513162, gi... - gi\|117624038\|ref\|YP_852951.1\| chemotaxis protein CheA [Escherichia coli APEC O1], gi\|115513162\|gb\|AB...	407.0	[0..2]	[654..15]
gi\|75195952 - gi\|75195952\|ref\|ZP_00706022.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc...	407.0	[0..3]	[654..1]
gi\|75190916 - gi\|75190916\|ref\|ZP_00704183.1\| COG0643: Chemotaxis protein histidine kinase and related kinases [Esc...	407.0	[0..3]	[654..1]

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Predicted Domain #1

Region A:
Residues: [1-125]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMDISDFYQ TFFDEADELL ADMEQHLLVL QPEAPDAEQL NAIFRAAHSI KGGAGTFGFS  60
   61 VLQETTHLME NLLDEARRGE MQLNTDIINL FLETKDIMQE QLDAYKQSQE PDAASFDYIC 120
  121 QALRQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.39794
Match:	1i5nA
Description:	Chemotaxis protein CheA P1 domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.1118000424713	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [126-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LALEAKGETP SAVTRLSVVA KSEPQDEQSR SQSPRRIILS RLKAGEVDLL EEELGHLTTL  60
   61 TDVVKGADSL SAILPGDIAE DDITAVLCFV IEADQITFET VEVSPKISTP PVLKLAAEQA 120
  121 PTGRVEREKT TR

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	7.89
Match:	1fwpA
Description:	CHEY-BINDING DOMAIN OF CHEA (RESIDUES 159-227), NMR, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [258-654]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNESTSIRVA VEKVDQLINL VGELVITQSM LAQRSSELDP VNHGDLITSM GQLQRNARDL  60
   61 QESVMSIRMM PMEYVFSRYP RLVRDLAGKL GKQVELTLVG SSTELDKSLI ERIIDPLTHL 120
  121 VRNSLDHGIE LPEKRLAAGK NSVGNLILSA EHQGGNICIE VTDDGAGLNR ERILAKAASQ 180
  181 GLTVSENMSD DEVAMLIFAP GFSTAEQVTD VSGRGVGMDV VKRNIQKMGG HVEIQSKQGT 240
  241 GTTIRILLPL TLAILDGMSV RVADEVFILP LNAVMESLQP READLHPLAG GERVLEVRGE 300
  301 YLPIVELWKV FNVAGAKTEA TQGIVVILQS GGRRYALLVD QLIGQHQVVV KNLESNYRKV 360
  361 PGISAATILG DGSVALIVDV SALQAINREQ RMANTAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.154902
Match:	1b3qA
Description:	Histidine kinase CheA; Histidine kinase CheA, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
signal transducer activity	0.136077038453936	bayes_pls_golite062009
molecular transducer activity	0.136077038453936	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: