YRC Public Data Repository - Protein Structure Prediction

Protein:	APPY_ECOLI
Organism:	Escherichia coli
Length:	249 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APPY_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|115251072, gi... - gi\|126699635\|ref\|YP_001088532.1\| AraC family transcription regulator [Clostridium difficile 630], gi... gi\|255101149 - gi\|255101149\|ref\|ZP_05330126.1\| AraC family transcription regulator [Clostridium difficile QCD-63q42...	156.0	[0..2]	[238..37]
gi\|32396734, gi\|... - gi\|32471032\|ref\|NP_864025.1\| L-rhamnose operon transcriptional activator [Rhodopirellula baltica SH ...	155.0	[0..2]	[238..38]
gi\|254975611 - gi\|254975611\|ref\|ZP_05272083.1\| AraC family transcription regulator [Clostridium difficile QCD-66c26... gi\|255092999 - gi\|255092999\|ref\|ZP_05322477.1\| AraC family transcription regulator [Clostridium difficile CIP 10793... gi\|119635337, gi... - gi\|90574406\|ref\|ZP_01230906.1\| hypothetical protein CdifQ_02002158 [Clostridium difficile QCD-32g58]... gi\|255314740 - gi\|255314740\|ref\|ZP_05356323.1\| AraC family transcription regulator [Clostridium difficile QCD-76w55... gi\|255517414 - gi\|255517414\|ref\|ZP_05385090.1\| AraC family transcription regulator [Clostridium difficile QCD-97b34... gi\|255650524 - gi\|255650524\|ref\|ZP_05397426.1\| AraC family transcription regulator [Clostridium difficile QCD-37x79...	155.0	[0..2]	[238..37]
gi\|74275922, gi\|... - gi\|75436836\|ref\|ZP_00733351.1\| AraC-type DNA-binding domain-containing proteins [Actinobacillus succ...	155.0	[0..6]	[232..47]
gi\|25501439 - pir\|\|H97078 araC-type DNA-binding domain-containing protein [imported] - Clostridium acetobutylicum gi\|15024394, gi\|... - gi\|15894730\|ref\|NP_348079.1\| AraC-type DNA-binding domain-containing protein [Clostridium acetobutyl...	155.0	[0..2]	[240..39]
gi\|27367437, gi\|... - gi\|27367437\|ref\|NP_762964.1\| AraC-type DNA-binding domain-containing protein [Vibrio vulnificus CMCP...	155.0	[0..1]	[236..34]
gi\|67677408, gi\|... - gi\|92114725\|ref\|YP_574653.1\| AraC family transcriptional regulator [Chromohalobacter salexigens DSM ...	154.0	[0..2]	[236..45]
gi\|146296375, gi... - gi\|82499254\|ref\|ZP_00884703.1\| Helix-turn-helix, AraC type [Caldicellulosiruptor saccharolyticus DSM...	154.0	[0..2]	[237..40]
gi\|77458866, gi\|... - gi\|77458866\|ref\|YP_348372.1\| AraC family transcriptional regulator [Pseudomonas fluorescens Pf0-1], ...	154.0	[0..4]	[235..43]
gi\|89093332, gi\|... - gi\|89093332\|ref\|ZP_01166281.1\| putative transcription regulator protein [Oceanospirillum sp. MED92],...	154.0	[0..1]	[233..34]

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Predicted Domain #1

Region A:
Residues: [1-132]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYVCSVVFI CQSFDLIINR RVISFKKNSL FIVSDKIRRE LPVCPSKLRI VDIDKKTCLS  60
   61 FFIDVNNELP GKFTLDKNGY IAEEEPPLSL VFSLFEGIKI ADSHSLWLKE RLCISLLAMF 120
  121 KKRESVNSFI LT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	1xjaA
Description:	Apo form of the Y31V mutant dimerization domain fragment of Escherichia coli regulatory protein AraC
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [133-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINTFTCKIT GIISFNIERQ WHLKDIAELI YTSESLIKKR LRDEGTSFTE ILRDTRMRYA  60
   61 KKLITSNSYS INVVAQKCGY NSTSYFICAF KDYYGVTPSH YFEKIIGVTD GINKTID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.0
Match:	1d5yA
Description:	Rob transcription factor, N-terminal domain; Rob transcription factor, C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits