YRC Public Data Repository - Protein Structure Prediction

Protein:	AES_ECOLI
Organism:	Escherichia coli
Length:	319 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AES_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|51893263, gi\|... - gi\|51893263\|ref\|YP_075954.1\| putative lipase [Symbiobacterium thermophilum IAM 14863], gi\|51856952\|d...	240.0	[0..11]	[319..1]
gi\|45775291 - gi\|45775291\|gb\|AAS77247.1\| lipase/esterase [uncultured bacterium]	239.0	[0..11]	[316..1]
gi\|33325033 - gi\|33325033\|gb\|AAQ08176.1\| lipase/esterase [Bacillus megaterium]	237.0	[0..11]	[319..1]
gi\|86750145, gi\|... - gi\|86750145\|ref\|YP_486641.1\| esterase/lipase/thioesterase [Rhodopseudomonas palustris HaA2], gi\|8657...	235.0	[0..9]	[317..1]
gi\|76445762 - gi\|76445762\|gb\|ABA42743.1\| esterase [Bacillus sp. NK13]	234.0	[0..11]	[319..1]
gi\|90331599, gi\|... - gi\|90416400\|ref\|ZP_01224331.1\| Esterase/lipase/thioesterase [marine gamma proteobacterium HTCC2207],... gi\|90416400\|ref\|... - Esterase/lipase/thioesterase [marine gamma proteobacterium HTCC2207]	232.0	[0..10]	[318..15]
gi\|15899234, gi\|... - gi\|15899234\|ref\|NP_343839.1\| lipase (lipP-1) [Sulfolobus solfataricus P2], gi\|13815796\|gb\|AAK42629.1... gi\|25393150 - pir\|\|F90421 lipase (lipP-1) [imported] - Sulfolobus solfataricus gi\|227455780, gi... - gi\|227829333\|ref\|YP_002831112.1\| Alpha/beta hydrolase fold-3 domain protein [Sulfolobus islandicus L... gi\|229583318, gi... - gi\|229583318\|ref\|YP_002841717.1\| Alpha/beta hydrolase fold-3 domain protein [Sulfolobus islandicus Y...	232.0	[0..11]	[319..1]
gi\|56798147\|dbj\|... - carboxylesterase [Sulfolobus shibatae] gi\|56798147 - gi\|56798147\|dbj\|BAD82944.1\| carboxylesterase [Sulfolobus shibatae]	231.0	[0..11]	[319..1]
gi\|114317206, gi... - gi\|114329032\|ref\|YP_746189.1\| acetyl esterase [Granulibacter bethesdensis CGDNIH1], gi\|114317206\|gb\|...	231.0	[0..11]	[317..10]
gi\|73539284, gi\|... - gi\|73539284\|ref\|YP_299651.1\| esterase/lipase/thioesterase [Ralstonia eutropha JMP134], gi\|72122621\|g...	229.0	[0..11]	[306..1]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPENKLPVL DLISAEMKTV VNTLQPDLPP WPATGTIAEQ RQYYTLERRF WNAGAPEMAT  60
   61 RAYMVPTKYG QVETRLFCPQ PDSPATLFYL HGGGFILGNL DTHDRIMRLL ASYSQCTVIG 120
  121 IDYTLSPEAR FPQAIEEIVA ACCYFHQQAE DYQINMSRIG FAGDSAGAML ALASALWLRD 180
  181 KQIDCGKVAG VLLWYGLYGL RDSVTRRLLG GVWDGLTQQD LQMYEEAYLS NDADRESPYY 240
  241 CLFNNDLTRE VPPCFIAGAE FDPLLDDSRL LYQTLAAHQQ PCEFKLYPGT LHAFLHYSRM 300
  301 MKTADEALRD GAQFFTAQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.39794
Match:	1evqA
Description:	Carboxylesterase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.76673721118052	bayes_pls_golite062009
hydrolase activity	0.694748566370871	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.0280628305353907	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: