YRC Public Data Repository - Protein Structure Prediction

Protein:	MTHR1_ARATH
Organism:	Arabidopsis thaliana
Length:	592 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTHR1_ARATH.

Description	E-value	Query Range	Subject Range
MTHR_ORYSA - Probable methylenetetrahydrofolate reductase (EC 1.5.1.20) - Oryza sativa (Rice) gi\|125546191 - gi\|125546191\|gb\|EAY92330.1\| hypothetical protein OsI_14054 [Oryza sativa Indica Group] MTHR_ORYSJ - Probable methylenetetrahydrofolate reductase OS=Oryza sativa subsp. japonica GN=Os03g0815200 PE=2 SV...	850.0	[0..1]	[591..1]
MTHR1_MAIZE - Methylenetetrahydrofolate reductase 1 OS=Zea mays PE=2 SV=1	845.0	[0..1]	[591..1]
MTHR2_ARATH - Methylenetetrahydrofolate reductase 2 OS=Arabidopsis thaliana GN=MTHFR2 PE=1 SV=2	838.0	[0..1]	[592..1]
gi\|67539426, gi\|... - gi\|67539426\|ref\|XP_663487.1\| hypothetical protein AN5883.2 [Aspergillus nidulans FGSC A4], ref\|XP_41... gi\|113911583 - gi\|113911583\|gb\|ABI48273.1\| methylenetetrahydrofolate reductase [Emericella nidulans]	835.0	[0..1]	[591..1]
gi\|71001564, gi\|... - gi\|71001564\|ref\|XP_755463.1\| methylenetetrahydrofolate reductase [Aspergillus fumigatus Af293], gi\|6...	832.0	[0..1]	[591..1]
gi\|119178804, gi... - gi\|90299825\|gb\|EAS29456.1\| hypothetical protein CIMG_08202 [Coccidioides immitis RS], gi\|119178804\|r...	832.0	[0..1]	[591..1]
gi\|115384530, gi... - gi\|115384530\|ref\|XP_001208812.1\| methylenetetrahydrofolate reductase 2 [Aspergillus terreus NIH2624]...	830.0	[0..1]	[591..1]

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Predicted Domain #1

Region A:
Residues: [1-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVVDKIKSV TEQGQTAFSF EFFPPKTEDG VENLFERMDR LVSYGPTFCD ITWGAGGSTA  60
   61 DLTLEIASRM QNVICVETMM HLTCTNMPIE KIDHALETIR SNGIQNVLAL RGDPPHGQDK 120
  121 FVQVEGGFAC ALDLVNHIRS KYGDYFGITV AGYPEAHPDV IEADGLATPE SYQSDLAYLK 180
  181 KKVDAGADLI VTQLFYDTDI FLKFVNDCRQ IGINCPIVPG IMPISNYKGF LRMAGFCKTK 240
  241 IPAELTAALE PIKDNDEAVK AYGIHFATEM CKKILAHGIT SLHLYTLNVD KSAIGILMNL 300
  301 GLIDESKISR S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	99.0
Match:	1v93A
Description:	5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [312-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPWRRPANVF RTKEDVRPIF WANRPKSYIS RTKGWNDFPH GRWGDSHSAA YSTLSDYQFA  60
   61 RPKGRDKKLQ QEWVVPLKSI EDVQEKFKEL CIGNLKSSPW SELDGLQPET KIINEQLGKI 120
  121 NSNGFLTINS QPSVNAAKSD SPAIGWGG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [460-592]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGGYVYQKAY LEFFCSKDKL DTLVEKSKAF PSITYMAVNK SENWVSNTGE SDVNAVTWGV  60
   61 FPAKEVIQPT IVDPASFKVW KDEAFEIWSR SWANLYPEDD PSRKLLEEVK NSYYLVSLVD 120
  121 NNYINGDIFS VFA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits