YRC Public Data Repository - Protein Structure Prediction

Protein:	WNK1_ARATH
Organism:	Arabidopsis thaliana
Length:	700 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for WNK1_ARATH.

Description	E-value	Query Range	Subject Range
gi\|79312817 - gi\|79312817\|ref\|NP_001030637.1\| WNK1 (WITH NO LYSINE (K) 1); kinase/ protein kinase/ protein serine/...	415.0	[0..39]	[700..16]
gi\|76647955 - gi\|76647955\|ref\|XP_584975.2\| PREDICTED: similar to CDC42-binding protein kinase beta [Bos taurus]	346.0	[0..6]	[684..334]
gi\|50756157 - gi\|50756157\|ref\|XP_415041.1\| PREDICTED: similar to CDC42-binding protein kinase alpha isoform B; ser...	336.0	[0..8]	[682..80]
gi\|73960799 - gi\|73960799\|ref\|XP_863624.1\| PREDICTED: similar to CDC42-binding protein kinase alpha isoform B isof...	328.0	[0..8]	[682..61]
gi\|125533559 - gi\|125533559\|gb\|EAY80107.1\| hypothetical protein OsI_35279 [Oryza sativa Indica Group] gi\|115484405, gi... - gi\|77548838\|gb\|ABA91635.1\| Calcium-dependent protein kinase, isoform AK1, putative, expressed [Oryza...	324.0	[0..21]	[493..44]
gi\|94364647, gi\|... - gi\|94364647\|ref\|XP_981011.1\| PREDICTED: similar to mytonic dystrophy kinase-related Cdc42-binding ki...	324.0	[0..8]	[682..61]

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Predicted Domain #1

Region A:
Residues: [1-288]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNLSYLEPD YSEFVEVDPT GRYGRYNEVL GKGASKTVYR AFDEYEGIEV AWNQVKLYDF  60
   61 LQSPEDLERL YCEIHLLKTL KHKNIMKFYT SWVDTANRNI NFVTELFTSG TLRQYRLRHK 120
  121 RVNIRAMKHW CRQILRGLHY LHSHDPPVIH RDLKCDNIFV NGNQGEVKIG DLGLAAILRK 180
  181 SHAAHCVGTP EFMAPEVYEE AYNELVDIYS FGMCILEMVT FDYPYSECTH PAQIYKKVMS 240
  241 GKKPDALYKV KDPEVKCFIE KCLATVSLRV SARELLDDPF LRIDDGEF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.221849
Match:	1t4hA
Description:	Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [289-364]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLRSVDMEDS VGPLYRQPHH LPDYYNYPSN SSSLNRQYSN GNYPSNSSSL NRQYSNGYNS  60
   61 HHEYQNGWAY NPAETE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [365-700]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETHGIELFES RNNDDQEEEK KSGNVDITIK GKRRDDGGLF LRLRIADKEG RVRNIYFPFD  60
   61 IETDTALSVA TEMVAELDMD DHGVTKIANM IDGEISSLVP SWRPGPEFEE CLAAAAAANA 120
  121 ASICNNCVSN RTSMGSVMDF LRTNPGANVI QCCRNGCGET HGRFEEITIR ETEVRLRELW 180
  181 KLQQQQESRE LSSIDSGHNH SEEEEEEEVL YEDPENMFSC EAGNEINHIS GSGSFSFMPS 240
  241 KYCDEPSEKT ENQVQQELRW LKAKCQIELR DIQDEQLKTR WPESGEEVEI SPKDGFLGSV 300
  301 SGLGREEDTV KEMFGERLVP KCLKRTTSLP VDAIDS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.09691
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits