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View Structure Prediction Details

Protein: sym-2
Organism: Caenorhabditis elegans
Length: 618 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sym-2.

Description E-value Query
Range
Subject
Range
gi|73974158 - gi|73974158|ref|XP_848864.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
334.0 [0..90] [618..13]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRQTSHPEQ RLLLIRVSDG NYDENTKLVV TSFYPRRQED ANNNSTSPSS ASSSGSEIST  60
   61 RLVNITPEDV VKFFDEHPTS SYIFTKG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEPIRHVLIP LFARNELCVP HPLHHYYDIK HLYYGNQEED GMEQEEIEDD VAIARAILDM  60
   61 DDELLEKTHQ FVNIEYQPAP ILEDQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.221849
Match: 1fjeB
Description: Nucleolin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [174-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGADGDNVVC RARGLPWQAS DHHVAQFFAG LDIVPGGIAL CLSSEGRRNG EVLVQFSSQE  60
   61 SRDLALKRHR NFLLSRYIEV YKAGLDEFMH VATGSSTEAM EFVSANAIIV RMRGLPYDCT 120
  121 DAQIRTFFEP LKLTDKILFI TRTDGRPTGD AFVQFETEED AQQGLLKHRQ VIGQRYIELF 180
  181 KSTAAEVQQV VKRCNLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.30103
Match: 1pgzA
Description: Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [371-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPAVANAV EAPEEKKKDC VRLRGLPYEA TVQHIVTFLG DFATMVKFQG VHMVYNNQGH  60
   61 PSGEAFIQMI NEQAASACAA GVHNNFMSVG KKKRYIEVFQ ASAEELNLHH LVGQQHQVPP 120
  121 PAPLGFMGQL PPQAPQPQQF W

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 2adbA
Description: Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [512-618]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSYPSPPISP IVPGQVTQLI IYGIHMSIGV PELVANFTTP EHTVDNVLFT RWPTHLCPGE  60
   61 AILTLRNRGA PPPQTSPLSQ ISQLSAPNFA AYSHHPQNFP LQPILME

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1u6fA
Description: NMR solution structure of TcUBP1, a single RBD-unit from Trypanosoma cruzi
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30587477666777 bayes_pls_golite062009
nucleic acid binding 1.2660519582186 bayes_pls_golite062009
protein binding 0.88951142240317 bayes_pls_golite062009
RNA binding 0.498012521772139 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle