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View Structure Prediction Details

Protein: tbc-1
Organism: Caenorhabditis elegans
Length: 641 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tbc-1.

Description E-value Query
Range
Subject
Range
gi|114588170 - gi|114588170|ref|XP_516624.2| PREDICTED: hypothetical protein isoform 5 [Pan troglodytes]
533.0 [0..12] [632..18]

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Predicted Domain #1
Region A:
Residues: [1-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGETGPTNNT SFSSLDDNWE TDVNVLSSEL GDLDTEGNDK SDWMRLLGVS MKPNPLDDWD  60
   61 QLYNLNNQCA LRNDCRKLAN GLKNKRSVPE LESFLTLYCK KRGMDYIKDI GWLTILEKIL 120
  121 LLNVPAAHEF NVFFAFTTKY IPKDTRPDAQ IFDLFRLLLQ YHDPQISNHL ESLHCSPSMY 180
  181 TKNWFATLFS SSMSTESCHE LWKLYIEQGD PFLVFHLAIV FLINAKDEIL QVKRDEKEKA 240
  241 VQILENMAAQ LSVEDVPDFF QLALHYSDKT PECIRKDFHY IIFGANFDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 2qfzA
Description: No description for 2qfzA was found.

Predicted Domain #2
Region A:
Residues: [290-441]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVKEIQMNKM LCLPIPAIDL TSHDEISSGS VNFFIVDTRS NTDFDSGHFV SSFNLDCVAI  60
   61 VDEPEKFEIA LNSLECYKTS RRDEDHYLIL GYGSDEEDNY MNMLIAMFIQ KGKLHVSFVQ 120
  121 GGYKKLHDCI GQHNRWELIA MHSEDRCELC SS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.67
Match: 1hzmA
Description: Erk2 binding domain of Mapk phosphatase mkp-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.708103811735445 bayes_pls_golite062009
protein binding 0.279521784602446 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [442-528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKASPKWGFF SKMKSAVSNT SSRMKERVEA VVFPIGEEKK LDDKHADSKQ RHGKRYRQQS  60
   61 VFTIDENSDD EMAAGAAVDE NPKEEIL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [529-641]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSKEFTETFE CQEVFRDGSI NGHIALTRTH IYVLHDVPGK QGYVTTEARH ALSTVVAVTS  60
   61 RRSVPEMLTF KLGYEMNGSS KITAVHKLYV PKAGECAKAV KLAIYALRPL PDA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle