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View Structure Prediction Details

Protein: unc-43
Organism: Caenorhabditis elegans
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-43.

Description E-value Query
Range
Subject
Range
gi|73952969, gi|... - gi|73952975|ref|XP_863150.1| PREDICTED: similar to calcium/calmodulin-dependent protein kinase II ga...
gi|18448917 - gi|18448917|gb|AAL69955.1| CaM kinase II gamma B [Mustela putorius furo]
gi|1657458 - gi|1657458|gb|AAC48711.1| calcium/calmodulin-dependent protein kinase II isoform gamma-B [Sus scrofa...
gi|26667199, gi|... - gi|422769|pir||B46619 Ca2+/calmodulin-dependent protein kinase (EC 2.7.1.123) II gamma chain, splice...
gi|85362742, gi|... - gi|85362742|ref|NP_001034227.1| calcium/calmodulin-dependent protein kinase II gamma isoform 2 [Mus ...
554.0 [0..6] [514..8]

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Predicted Domain #1
Region A:
Residues: [1-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA RDFQKLEREA  60
   61 RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI VAREFYSEAD ASHCIQQILE 120
  121 SIAYCHSNGI VHRDLKPENL LLASKAKGAA VKLADFGLAI EVNDSEAWHG FAGTPGYLSP 180
  181 EVLKKDPYSK PVDIWACGVI LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP 240
  241 EAKSLIDSML TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKGA 300
  301 ILTTMIATRN LSNLGRNLLN KKEQGPPSTI KESSESSQTI DDNDSEKGGG QLKHENTVVR 360
  361 ADGATGIVSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 90.69897
Match: 2bdwA
Description: Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [371-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSSTASKSS STNLSAQKQD IVRVTQTLLD AISCKDFETY TRLCDTSMTC FEPEALGNLI  60
   61 EGIEFHRFYF DGNRKNQVHT TMLNPNVHII GEDAACVAYV KLTQFLDRNG EAHTRQSQES 120
  121 RVWSKKQGRW VCVHVHRSTQ PSTNTTVSEF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.522879
Match: 2f86B
Description: The Association Domain of C. elegans CaMKII
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle