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View Structure Prediction Details

Protein: sli-1
Organism: Caenorhabditis elegans
Length: 582 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sli-1.

Description E-value Query
Range
Subject
Range
sli-1 - adaptor-like E3 ubiquitin ligase status:Partially_confirmed UniProt:Q95ZR5 protein_id:AAK84547.1
548.0 [0..1] [582..1]

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Predicted Domain #1
Region A:
Residues: [1-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSINTIFHR IHRFVNGTGN NARFVPSTNN STEALTLSPR AVPSTVSLFE IPSASEMPGF  60
   61 CSEEDRRFLL KACKFMDQVV KSCHSPRLNL KNSPPFILDI LPDTYTHLML IFTQNNDILQ 120
  121 DNDYLKIFLE SMINKCKEII KLFKTSAIYN DQSEERRKLT KMSLTFSHML FEIKALFPEG 180
  181 IYIEDRFRMT KKEAESFWSH HFTKKNIVPW STFFTALEKH HGSTIGKMEA AELKATIDLS 240
  241 GDDFISNFEF DVFTRLFYPF KTLIKNWQTL TTAHPGYCAF LTYDEVKKRL EKLTKKPGSY 300
  301 IFRLSCTRPG QWAIGYVAPD GKIYQTIPQN KSLIQALHEG HKEGFYIYPN GRDQDINLSK 360
  361 LMDVPQADRV QVTSEQYELY CEMGTTFELC KICDDNEKNI KIEPCGHLLC AKCLANWQDS 420
  421 DGGGNTCPFC RYEIKGTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1fbvA
Description: Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.78762232945822 bayes_pls_golite062009
protein binding 1.4273874265634 bayes_pls_golite062009
signal transducer activity 1.37370552536239 bayes_pls_golite062009
molecular transducer activity 1.37370552536239 bayes_pls_golite062009
epidermal growth factor receptor binding 1.03934535504406 bayes_pls_golite062009
molecular adaptor activity 0.58947294551094 bayes_pls_golite062009
SH3/SH2 adaptor activity 0.52889761132084 bayes_pls_golite062009
calcium ion binding 0.292797014921594 bayes_pls_golite062009
insulin receptor binding 0.28737567192381 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.253080312769269 bayes_pls_golite062009
receptor binding 0.24683439420295 bayes_pls_golite062009
kinase activity 0.246780195377285 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.16106219404884 bayes_pls_golite062009
protein binding, bridging 0.0904972759345899 bayes_pls_golite062009
hydrolase activity 0.062117874431973 bayes_pls_golite062009
protein kinase activity 0.0337037979217971 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [439-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVIIDRFKPT PVEIEKAKNV AAAEKKLISL VPDVPPRTYV SQCSQSLLHD ASNSIPSVDE  60
   61 LPLVPPPLPP KALGTLDTLN SSQTSSSYVN IKELENVETS GEALAQVVNR QRAPSIQAPP 120
  121 LPPRLSASEH QPHHPYTNTN SERE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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